A Minimal Exercise Extension for Models of the Glucoregulatory System

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Cognitive Impairment and Metabolite Profile Alterations in the Hippocampus and Cortex of Male and Female Mice Exposed to a Fat and Sugar-Rich Diet are Normalized by Diet Reversal

João Miguel das Neves Duarte, Adélaïde Alice Mohr

Diabetes impacts on brain metabolism, structure, and function. Alterations in brain metabolism have been observed in obesity and diabetes models induced by exposure to diets rich in saturated fat and/or sugar and have been linked to memory impairment. Howe ...

INT SOC AGING & DISEASE2022

Metabolic regulation of cytokinesis in Schizosaccharomyces pombe

Özge Uysal Özdemir

All cells need to be able to sense their environment, and adapt their metabolism, growth and cell division appropriately. In this study, I examined the response of Schizosaccharomyces pombe to a change in the carbon source and how that affects cytokinesis. ...

EPFL2022

Hypothalamic pregnenolone mediates recognition memory in the context of metabolic disorders

Maria del Carmen Sandi Perez, Ioannis Zalachoras

Obesity and type 2 diabetes are associated with cognitive dysfunction. Because the hypothalamus is implicated in energy balance control and memory disorders, we hypothesized that specific neurons in this brain region are at the interface of metabolism and ...

Cell Press2022

Adaptive R-Peak Detection on Wearable ECG Sensors for High-Intensity Exercise

David Atienza Alonso, Grégoire Millet, Tomas Teijeiro Campo, Elisabetta De Giovanni

Objective: Continuous monitoring of biosignals via wearable sensors has quickly expanded in the medical and wellness fields. At rest, automatic detection of vital parameters is generally accurate. However, in conditions such as high-intensity exercise, sud ...

2022

Rapid, Sensitive and Selective Optical Glucose Sensing with Stimulated Raman Scattering (SRS)

Christian Enz, Sandro Carrara, Assim Boukhayma, Ata Jedari Golparvar

Optical blood glucose sensing offers pain-free, non-invasive, continuous monitoring with minimum risk of infection since it does not require breaking the skin barrier. Among various optical detection and spectroscopic techniques, only Raman scattering offe ...

IEEE2022

Machine learning-derived gut microbiome signature predicts fatty liver disease in the presence of insulin resistance

Johan Auwerx, Dongryeol Ryu

A simple predictive biomarker for fatty liver disease is required for individuals with insulin resistance. Here, we developed a supervised machine learning-based classifier for fatty liver disease using fecal 16S rDNA sequencing data. Based on the Kangbuk ...

Nature Portfolio2022

Sphingolipids accumulate in aged muscle, and their reduction counteracts sarcopenia

Johan Auwerx, Maroun Bou Sleiman, Davide D'Amico, Tanes Imamura de Lima, Pirkka-Pekka Untamo Laurila, Martin Rainer Wohlwend, Peiling Luan, Qi Wang, Sébastien Robert Victor Herzig

Age-related muscle dysfunction and sarcopenia are major causes of physical incapacitation in older adults and currently lack viable treatment strategies. Here we find that sphingolipids accumulate in mouse skeletal muscle upon aging and that both genetic a ...

2022

NP Satisfiability for Arrays as Powers

Viktor Kuncak, Rodrigo Raya

We show that the satisfiability problem for the quantifier-free theory of product structures with the equicardinality relation is inNP. As an application, we extend the combinatory array logic fragmentto handle cardinality constraints. The resulting fragme ...

Springer, Cham2022

Cost Effective Synthesis of Graphene Nanomaterials for Non-Enzymatic Electrochemical Sensors for Glucose: A Comprehensive Review

Theodoros Damartzis

The high conductivity of graphene material (or its derivatives) and its very large surface area enhance the direct electron transfer, improving non-enzymatic electrochemical sensors sensitivity and its other characteristics. The offered large pores facilit ...

MDPI2022

Real-Time Nonlinear Model Predictive Control for Fast Mechatronic Systems

Petr Listov

This thesis presents an efficient and extensible numerical software framework for real-time model-based control. We are motivated by complex and challenging mechatronic applications spanning from flight control of fixed-wing aircraft and thrust vector cont ...

EPFL2022

A combined Control by Interconnection—Model Predictive Control design for constrained Port-Hamiltonian systems

Anna Ngoc Minh Trang Vu

This paper proposes a Control by Interconnection design, for a class of constrained Port-Hamiltonian systems, which is based on an associated Model Predictive Control optimization problem. This associated optimization problem allows to consider both state ...

2022

Transformation of Glucose to 5-Hydroxymethylfurfural Over Regenerated Cellulose Supported Nb2O5 center dot nH(2)O in Aqueous Solution

Fangmin Huang, Paul Joseph Dyson, Zhaofu Fei, Lu Chen

Niobic acid (Nb2O5 center dot nH(2)O) was immobilized on regenerated cellulose (Re-Cellulose) to afford a heterogeneous catalyst, termed Nb2O5 center dot nH(2)O@Re-Cellulose, that was characterized by powder X-ray diffraction, microscopy (SEM and TEM) and ...

SPRINGER2020