The genetic architecture of complex human traits at the dawn of genomic medicine

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The adaptation of organisms to their environment depends on the innovative potential inherent to genetic variation. In complex organisms such as mammals, processes like development and immunity require tight gene regulation. Complex forms emerge more often ...

Cis-genetic effects are key determinants of transcriptional divergence in discrete tissues and cell types. However, how cis- and trans-effects act across continuous trajectories of cellular differentiation in vivo is poorly understood. Here, we quantify al ...

Enhancing tree diversity may be important to fostering resilience to drought-related climate extremes. So far, little attention has been given to whether tree diversity can increase the survival of trees and reduce its variability in young forest plantatio ...

Analysis of single-cell datasets generated from diverse organisms offers unprecedented opportunities to unravel fundamental evolutionary processes of conservation and diversification of cell types. However, interspecies genomic differences limit the joint ...

Traditional martial arts are treasures of humanity's knowledge and critical carriers of sociocultural memories throughout history. However, such treasured practices have encountered various challenges in knowledge transmission and now feature many entries ...

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Large language models (LLMs) have shown strong performance in tasks across domains but struggle with chemistry-related problems. These models also lack access to external knowledge sources, limiting their usefulness in scientific applications. We introduce ...

Growing evidence indicates that transposable elements (TEs) play important roles in evolution by providing genomes with coding and non-coding sequences. Identification of TE-derived functional elements, however, has relied on TE annotations in individual s ...

Background: We previously described the KINSSHIP syndrome, an autosomal dominant disorder associated with intellectual disability (ID), mesomelic dysplasia and horseshoe kidney,caused by de novo variants in the degron of AFF3. Mouse knock-ins and overexpre ...

Here we provide the neural data, activation and predictions for the best models and result dataframes of our article "Task-driven neural network models predict neural dynamics of proprioception". It contains the behavioral and neural experimental data (cu ...

The genetic architecture of complex human traits at the dawn of genomic medicine

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Slope Deformation Prediction Combining Particle Swarm Optimization-Based Fractional-Order Grey Model and K-Means Clustering

Combining physics-based and data-driven models: advancing the frontiers of research with scientific machine learning

t-PiNet: A thermodynamics-informed hierarchical learning for discovering constitutive relations of geomaterials

Machine learning-enabled estimation of cardiac output from peripheral waveforms is independent of blood pressure measurement location in an in silico population

The cost of adaptability: resource availability constrains functional stability under pulsed disturbances

Meeting our Makers: Uncovering the cis-regulatory activity of transposable elements using statistical learning

The dynamic genetic determinants of increased transcriptional divergence in spermatids

Tree diversity reduces variability in sapling survival under drought

Toward universal cell embeddings: integrating single-cell RNA-seq datasets across species with SATURN

Ontology-based Knowledge Representation for Traditional Martial Arts

DATA-DRIVEN INVERSE DESIGN METHOD FOR TURBOMACHINERY

Validation of short-pulse reflectometry turbulence measurements with a synthetic diagnostic

Reproductive isolation arises during laboratory adaptation to a novel hot environment

Infusing structured knowledge priors in neural models for sample-efficient symbolic reasoning

Quantitative characterization of the inorganic phosphate gene regulatory networks in S. cerevisiae and bottom up engineering an orthogonal gene network

Quasi-operando Transmission Electron Microscopy Diagnostics for Electrocatalytic Processes in Liquids

Augmenting large language models with chemistry tools

Ancestral genome reconstruction enhances transposable element annotation by identifying degenerate integrants

Variant-specific pathophysiological mechanisms of AFF3 differently influence transcriptome profiles

Task-driven neural network models predict neural dynamics of proprioception: Experimental data, activations and predictions of neural network models