RIM Determines Ca²+ Channel Density and Vesicle Docking at the Presynaptic Active Zone

Chat with Graph Search

Ask any question about EPFL courses, lectures, exercises, research, news, etc. or try the example questions below.

DISCLAIMER: The Graph Chatbot is not programmed to provide explicit or categorical answers to your questions. Rather, it transforms your questions into API requests that are distributed across the various IT services officially administered by EPFL. Its purpose is solely to collect and recommend relevant references to content that you can explore to help you answer your questions.

We are constantly bombarded by sensory information and constantly making decisions on how to act. In order to optimally adapt behavior, we must judge which sequences of sensory inputs and actions lead to successful outcomes in specific circumstances. Neuro ...

Within the extracellular matrix, matricellular proteins are dynamically expressed nonstructural proteins that interact with cell surface receptors, growth factors, and proteases, as well as with structural matrix proteins. The cellular communication networ ...

Neocortical neurons can increasingly be divided into well-defined classes, but their activity patterns during quantified behavior remain to be fully determined. Here, we obtained membrane potential recordings from various classes of excitatory and inhibito ...

Background: Throughout the animal kingdom, GABA is the principal inhibitory neurotransmitter of the nervous system. It is essential for maintaining the homeostatic balance between excitation and inhibition required for the brain to operate normally. Identi ...

Short-term synaptic plasticity and modulations of the presynaptic vesicle release rate are key components of many working memory models. At the same time, an increasing number of studies suggests a potential role of astrocytes in modulating higher cognitiv ...

With the capabilities such as single-photon detection, time stamping and high-speed acquisition, time-resolved imaging based on single-photon avalanche diode (SPAD) detectors has found significant applications across diverse domains, including but not limi ...

Rectified-linear-unit (ReLU) neural networks, which play a prominent role in deep learning, generate continuous and piecewise-linear (CPWL) functions. While they provide a powerful parametric representation, the mapping between the parameter and function s ...

A stunning example of synaptic diversity is the postsynaptic target cell-type-dependent difference in synap-tic efficacy in cortical networks. Here, we show that CA1 pyramidal cell (PC) to fast spiking interneuron (FSIN) connections have 10-fold larger rel ...

Membrane fusion is essential for the basal functionality of eukaryotic cells. In physiological conditions, fusion events are regulated by a wide range of specialized proteins, operating with finely tuned local lipid composition and ionic environment. Fusog ...

Due to conservation of neuronal functioning across phyla, molecular targets of insecticides are similar in insects and vertebrates. Insecticides thus pose a risk to aquatic vertebrates, such as fish, and potentially cause neurotoxic effects. Although these ...

Central nervous system organogenesis is a complex process that obeys precise architectural rules. The impact that nervous system architecture may have on its functionality remains, however, relatively unexplored. To clarify this problem, we analyze the dev ...

Aims: Synaptic dysfunction in Parkinson's disease is caused by propagation of pathogenic alpha-synuclein between neurons. Previously, in multiple system atrophy (MSA), pathologically characterised by ectopic deposition of abnormal alpha-synuclein predomina ...

RIM Determines Ca²+ Channel Density and Vesicle Docking at the Presynaptic Active Zone

Chat with Graph Search

Striatal Dopamine Signals and Reward Learning

The matricellular protein Drosophila Cellular Communication Network Factor is required for synaptic transmission and female fertility

Membrane potential dynamics of excitatory and inhibitory neurons in mouse barrel cortex during active whisker sensing

A conditional GABAergic synaptic vesicle marker for Drosophila

Modulation of working memory duration by synaptic and astrocytic mechanisms

Time-resolved imaging with SPAD detectors

Stable parameterization of continuous and piecewise-linear functions

Different priming states of synaptic vesicles underlie distinct release probabilities at hippocampal excitatory synapses

Cholesterol-Containing Liposomes Decorated With Au Nanoparticles as Minimal Tunable Fusion Machinery

Mechanistic Understanding of Neurobehavioral Effects of Insecticides on the Larvae of Zebrafish (Danio rerio)

Puckered and JNK signaling in pioneer neurons coordinates the motor activity of the Drosophila embryo

Pathological substrate of memory impairment in multiple system atrophy