Publications related to Engineering nanoparticle vaccines : design principles for lymphatic targeting

Related publications (5)

FOXC2 controls adult lymphatic endothelial specialization, function, and gut lymphatic barrier preventing multiorgan failure

Mauro Delorenzi, Alexis Rapin, Dominique Velin

The mechanisms maintaining adult lymphatic vascular specialization throughout life and their role in coordinating inter-organ communication to sustain homeostasis remain elusive. We report that inactivation of the mechanosensitive transcription factor Foxc ...

AMER ASSOC ADVANCEMENT SCIENCE2021

Lymphatic vessel density is associated with CD8(+) T cell infiltration and immunosuppressive factors in human melanoma

Timothy Murray, Melody Swartz, Manuel Andreas Fankhauser

Increased density of tumor-associated lymphatic vessels correlates with poor patient survival in melanoma and other cancers, yet lymphatic drainage is essential for initiating an immune response. Here we asked whether and how lymphatic vessel density (LVD) ...

TAYLOR & FRANCIS INC2018

Optimization and regeneration kinetics of lymphatic-specific photodynamic therapy in the mouse dermis

Melody Swartz, Patrycja Nowak-Sliwinska

Lymphatic vessels transport fluid, antigens, and immune cells to the lymph nodes to orchestrate adaptive immunity and maintain peripheral tolerance. Lymphangiogenesis has been associated with inflammation, cancer metastasis, autoimmunity, tolerance and tra ...

Springer2014

Nanoparticle conjugation and pulmonary delivery enhance the protective efficacy of Ag85B and CpG against tuberculosis

Jeffrey Alan Hubbell, Melody Swartz, John McKinney, Neeraj Dhar, Alexandre de Titta, Marie Ballester, Cyntia De Piano

Vaccines that drive robust T-cell immunity against Mycobacterium tuberculosis (Mtb) are needed both for prophylactic and therapeutic purposes. We have recently developed a synthetic vaccine delivery platform with Pluronic-stabilized polypropylene sulfide n ...

2011

Segmentation of head and neck lymph node regions for radiotherapy planning, using active contour based atlas registration

Jean-Philippe Thiran, Meritxell Bach Cuadra, Valérie Duay, Subrahmanyam Venkata Ravi Mohana Sai Gorthi, Nawal Houhou

In this paper, we present the segmentation of the head and neck lymph node regions using a new active contour based atlas registration model. We propose to segment the lymph node regions without directly including them in the atlas registration process; in ...

2009