An approach to characterize mechanisms of action of anti-amyloidogenic compounds in vitro and in situ

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BackgroundMutations in the vacuolar protein sorting 35 ortholog (VPS35) gene cause late-onset, autosomal dominant Parkinson's disease (PD), with a single missense mutation (Asp620Asn, D620N) known to segregate with disease in families with PD. The VPS35 ge ...

Abnormal tau protein aggregates constitute a hallmark of Alzheimer's disease. The mechanisms underlying the initiation of tau aggregation in sporadic neurodegeneration remain unclear. Here we investigate whether a non-human prion can seed tau aggregation. ...

Huntington's disease (HD) is a late onset, inherited neurodegenerative disorder for which early pathogenic events remain poorly understood. Here we show that mutant exon 1 HTT proteins are recruited to a subset of cytoplasmic aggregates in the cell bodies ...

This paper presents a novel approach for the fabrication of miniaturized and fully printed metal-oxide (MOX) gas sensors on a polyimide (PI) substrate by using digital manufacturing of the functional layers, namely aerosol jet and inkjet printing technolog ...

Deep convolutional neural networks (CNNs), trained on corresponding pairs of high- and low-resolution images, achieve state-of-the-art performance in single-image super- resolution and surpass previous signal-processing based approaches. However, their per ...

Earth-like planets, dark energy and variability of fundamental physical constants can be discovered by observing wavelength shifts in the optical spectra of astronomical objects(1-5). These wavelength shifts are so tiny that exquisitely accurate and precis ...

Digital silicon photo-multipliers (SiPMs) have emerged in the recent past as a viable low cost alternative to photomultiplier tubes in positron emission tomography systems, providing multiple timestamps, energy and scintillation coordinates at high spatial ...

Electric fields can be effectively used to sense, manipulate, and move particles in lab-on-a-chip devices. Nevertheless, the throughput of such devices is a critical issue, which can be effectively improved by increasing the height of the microchannels. Fo ...

An approach to characterize mechanisms of action of anti-amyloidogenic compounds in vitro and in situ

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VPS35 and α-Synuclein fail to interact to modulate neurodegeneration in rodent models of Parkinson's disease

Trans‐seeding of Alzheimer‐related tau protein by a yeast prion

Correlative light and electron microscopy suggests that mutant huntingtin dysregulates the endolysosomal pathway in presymptomatic Huntington's disease

All-printed low-power metal oxide gas sensors on polymeric substrates

Kernel Modeling Super-Resolution on Real Low-Resolution Images

A microphotonic astrocomb

A Sensor Network Architecture for Digital SiPM-Based PET Systems

Metal-Coated SU-8 Structures for High-Density 3-D Microelectrode Arrays