Conserved sequenceIn evolutionary biology, conserved sequences are identical or similar sequences in nucleic acids (DNA and RNA) or proteins across species (orthologous sequences), or within a genome (paralogous sequences), or between donor and receptor taxa (xenologous sequences). Conservation indicates that a sequence has been maintained by natural selection. A highly conserved sequence is one that has remained relatively unchanged far back up the phylogenetic tree, and hence far back in geological time.
Transcriptional regulationIn molecular biology and genetics, transcriptional regulation is the means by which a cell regulates the conversion of DNA to RNA (transcription), thereby orchestrating gene activity. A single gene can be regulated in a range of ways, from altering the number of copies of RNA that are transcribed, to the temporal control of when the gene is transcribed. This control allows the cell or organism to respond to a variety of intra- and extracellular signals and thus mount a response.
Regulation of gene expressionRegulation of gene expression, or gene regulation, includes a wide range of mechanisms that are used by cells to increase or decrease the production of specific gene products (protein or RNA). Sophisticated programs of gene expression are widely observed in biology, for example to trigger developmental pathways, respond to environmental stimuli, or adapt to new food sources. Virtually any step of gene expression can be modulated, from transcriptional initiation, to RNA processing, and to the post-translational modification of a protein.
Transcription factorIn molecular biology, a transcription factor (TF) (or sequence-specific DNA-binding factor) is a protein that controls the rate of transcription of genetic information from DNA to messenger RNA, by binding to a specific DNA sequence. The function of TFs is to regulate—turn on and off—genes in order to make sure that they are expressed in the desired cells at the right time and in the right amount throughout the life of the cell and the organism.
Developmental biologyDevelopmental biology is the study of the process by which animals and plants grow and develop. Developmental biology also encompasses the biology of regeneration, asexual reproduction, metamorphosis, and the growth and differentiation of stem cells in the adult organism. The main processes involved in the embryonic development of animals are: tissue patterning (via regional specification and patterned cell differentiation); tissue growth; and tissue morphogenesis.
Chromium (web browser)Chromium is a free and open-source web browser project, mainly developed and maintained by Google. This codebase provides the vast majority of code for the Google Chrome browser, which is proprietary software and has some additional features. Chromium's logo is identical in shape to that of Google Chrome, but with blue colors instead of being multicolor. The Chromium codebase is widely used. Microsoft Edge, Samsung Internet, Opera, and many other browsers are based on the Chromium code.
DatabaseIn computing, a database is an organized collection of data (also known as a data store) stored and accessed electronically through the use of a database management system. Small databases can be stored on a , while large databases are hosted on computer clusters or cloud storage. The design of databases spans formal techniques and practical considerations, including data modeling, efficient data representation and storage, query languages, security and privacy of sensitive data, and distributed computing issues, including supporting concurrent access and fault tolerance.
Safari (web browser)Safari is a web browser developed by Apple. It is built into Apple's operating systems, including macOS, iOS, and iPadOS, and uses Apple's open-source browser engine WebKit, which was derived from KHTML. Safari was introduced in Mac OS X Panther in January 2003. It was included with the iPhone since the latter's first generation, which came out in 2007. At that time, Safari was the fastest browser on the Mac. Between 2007 and 2012, Apple maintained a Windows version, but abandoned it due to low market share.
Object–relational impedance mismatchObject–relational impedance mismatch creates difficulties going from data in relational data stores (relational database management system [“RDBMS”]) to usage in domain-driven object models. Object-orientation (OO) is the default method for business-centric design in programming languages. The problem lies in neither relational nor OO, but in the conceptual difficulty mapping between the two logic models. Both are logical models implementable differently on database servers, programming languages, design patterns, or other technologies.
Regulator geneA regulator gene, regulator, or regulatory gene is a gene involved in controlling the expression of one or more other genes. Regulatory sequences, which encode regulatory genes, are often at the five prime end (5') to the start site of transcription of the gene they regulate. In addition, these sequences can also be found at the three prime end (3') to the transcription start site. In both cases, whether the regulatory sequence occurs before (5') or after (3') the gene it regulates, the sequence is often many kilobases away from the transcription start site.
Evolutionary developmental biologyEvolutionary developmental biology (informally, evo-devo) is a field of biological research that compares the developmental processes of different organisms to infer how developmental processes evolved. The field grew from 19th-century beginnings, where embryology faced a mystery: zoologists did not know how embryonic development was controlled at the molecular level. Charles Darwin noted that having similar embryos implied common ancestry, but little progress was made until the 1970s.
Human Genome ProjectThe Human Genome Project (HGP) was an international scientific research project with the goal of determining the base pairs that make up human DNA, and of identifying, mapping and sequencing all of the genes of the human genome from both a physical and a functional standpoint. It started in 1990 and was completed in 2003. It remains the world's largest collaborative biological project. Planning for the project started after it was adopted in 1984 by the US government, and it officially launched in 1990.
Google ChromeGoogle Chrome is a cross-platform web browser developed by Google. It was first released in 2008 for Microsoft Windows, built with free software components from Apple WebKit and Mozilla Firefox. Versions were later released for Linux, macOS, iOS, and also for Android, where it is the default browser. The browser is also the main component of ChromeOS, where it serves as the platform for web applications. Most of Chrome's source code comes from Google's free and open-source software project Chromium, but Chrome is licensed as proprietary freeware.
Object–relational mappingObject–relational mapping (ORM, O/RM, and O/R mapping tool) in computer science is a programming technique for converting data between a relational database and the heap of an object-oriented programming language. This creates, in effect, a virtual object database that can be used from within the programming language. In object-oriented programming, data-management tasks act on objects that combine scalar values into objects. For example, consider an address book entry that represents a single person along with zero or more phone numbers and zero or more addresses.
FirefoxMozilla Firefox, or simply Firefox, is a free and open-source web browser developed by the Mozilla Foundation and its subsidiary, the Mozilla Corporation. It uses the Gecko rendering engine to display web pages, which implements current and anticipated web standards. In November 2017, Firefox began incorporating new technology under the code name "Quantum" to promote parallelism and a more intuitive user interface. Firefox is available for Windows 7 or later versions, macOS, and Linux.
Reference genomeA reference genome (also known as a reference assembly) is a digital nucleic acid sequence database, assembled by scientists as a representative example of the set of genes in one idealized individual organism of a species. As they are assembled from the sequencing of DNA from a number of individual donors, reference genomes do not accurately represent the set of genes of any single individual organism. Instead a reference provides a haploid mosaic of different DNA sequences from each donor.
Coding regionThe coding region of a gene, also known as the coding sequence (CDS), is the portion of a gene's DNA or RNA that codes for protein. Studying the length, composition, regulation, splicing, structures, and functions of coding regions compared to non-coding regions over different species and time periods can provide a significant amount of important information regarding gene organization and evolution of prokaryotes and eukaryotes. This can further assist in mapping the human genome and developing gene therapy.
Semantic WebThe Semantic Web, sometimes known as Web 3.0 (not to be confused with Web3), is an extension of the World Wide Web through standards set by the World Wide Web Consortium (W3C). The goal of the Semantic Web is to make Internet data machine-readable. To enable the encoding of semantics with the data, technologies such as Resource Description Framework (RDF) and Web Ontology Language (OWL) are used. These technologies are used to formally represent metadata. For example, ontology can describe concepts, relationships between entities, and categories of things.
Web applicationA web application (or web app) is application software that is accessed using a web browser. Web applications are delivered on the World Wide Web to users with an active network connection. In earlier computing models like client-server, the processing load for the application was shared between code on the server and code installed on each client locally. In other words, an application had its own pre-compiled client program which served as its user interface and had to be separately installed on each user's personal computer.
History of evolutionary thoughtEvolutionary thought, the recognition that species change over time and the perceived understanding of how such processes work, has roots in antiquity—in the ideas of the ancient Greeks, Romans, Chinese, Church Fathers as well as in medieval Islamic science.
