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Scaffold requirements for periodontal regeneration with enamel matrix derivative proteins

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Three-dimensional morphometry of strained bovine periodontal ligament using synchrotron radiation-based tomography

John Botsis, Joël Cugnoni, Marzio Bergomi

The periodontal ligament (PDL) is a highly vascularized soft connective tissue. Previous studies suggest that the viscous component of the mechanical response may be explained by the deformation-induced collapse and expansion of internal voids (i.e. chiefl ...

2010

Microstimulations at the bone implant interface upregulate osteoclast activation pathway

Dominique Pioletti, Alexandre Terrier, Vincent Stadelmann

Peri-implant bone resorption after total joint arthroplasty is a key parameter in aseptic loosening. Implant wear debris and biomechanical aspects have both been demonstrated to be part of the bone resorption process. However, neither of these two paramete ...

2008

Theroretical and experimental multi-scale study of an artificial bone construct : from tibial osteotomy to cell/fluid interaction

Luc Blecha

Synthetic bone substitutes are potentially the future gold standard in orthopaedic and traumatologic surgery. The availability of these bone substitutes with different biomechanical properties may well replace autografts in the future as they overcome comp ...

EPFL2007

Load Response of Periodontal Ligament: Assessment of Fluid Flow, Compressibility, and Effect of Pore Pressure

John Botsis, Marzio Bergomi

The periodontal ligament (PDL) functions both in tension and in compression. The presence of an extensive vascular network inside the tissue suggests a significant contribution of the fluid phase to the mechanical response. This study examined the load res ...

2010

A Fluorescent Sensor for Pyrophosphate Based on a Pd(II) Complex

Rosario Scopelliti, Kay Severin

A mixture of the Pd(II) complex [Pd(NO3)2(bipy)] (bipy = 2,2-bipyridine) and the fluorescent dye Methylcalcein blue (MCB) constitutes a chemosensing ensemble which can be used for the detection of pyrophosphate (PPi) by fluorescence spectroscopy. The senso ...

Royal Society of Chemistry2010

Fetal bone cells for tissue engineering

In this thesis, the potential use of fetal bone cells for tissue engineering was evaluated. At first, fetal bone cells were characterized in vitro regarding their proliferation rate, the induction of their osteoblastic phenotype, and their antigenicity. Th ...

EPFL2007

Mechanical response of periodontal ligament: Effects of specimen geometry, preconditioning cycles and time lapse

John Botsis, Marzio Bergomi

This study was conducted as part of research line addressing the mechanical response of periodontal ligament (PDL) to tensile-compressive sinusoidal loading The aim of the present project was to determine the effect of three potential sources of variabilit ...

2009

Calcium phosphate drug delivery system: influence of local zoledronate release on bone implant osteointegration

Dominique Pioletti, Bastian Peter

Despite total hip replacement (THR) gives generally satisfactory results, the quality of outcome in young patients is markedly decreased compared to the average THR outcome. For this population, pharmacological treatment with bisphosphonate would be benefi ...

2005

An exact formula for "tooth-to-tooth" permeance

Yves Perriard, Marcel Jufer, Miroslav Markovic

We present a new, completely original exact method to determine the permeance between two opposing iron teeth. This configuration is important because it is often encountered in electrical machines and apparatus. The method is based on conformal mapping. T ...

Institute of Electrical and Electronics Engineers2005

Bone healing induced by local delivery of an engineered parathyroid hormone prodrug

Jeffrey Alan Hubbell

Regenerative medicine requires innovative therapeutic designs to accommodate high morphogen concentrations in local depots, provide their sustained presence, and enhance cellular invasion and directed differentiation. Here we present an example for inducin ...

2009

Prediction of bone density around orthopedic implants delivering bisphosphonate

Dominique Pioletti, Alexandre Terrier, Vincent Stadelmann

The fixation of an orthopedic implant depends strongly upon its initial stability. Peri-implant bone may resorb shortly after the surgery. This resorbtion is directly followed by new bone formation and implants fixation strengthening, the so-called seconda ...

2009

With applications to the periodontal ligament: a nonlinear large strain viscoelastic law

Jörn Justiz

The soft tissue, called periodontal ligament (PDL), that connects the alveolar bone and the tooth root accounts to a large extent for the mobility, stress-distribution and, due to its viscoelastic properties, damping of the bone-tooth complex. The accurate ...

EPFL2004

Experimental and numerical investigations on the fluid contribution to the tensile-compressive mechanical behavior of the bovine periodontal ligament

Marzio Bergomi

Orthodontic treatments are all based on the experimental evidence that teeth can be forced to move in the dental arch by means of applied mechanical forces. Since it allows for prediction of dental mobility, the mechanical characterization of the tissues i ...

EPFL2008

Regional structural characteristics of bovine periodontal ligament samples and their suitability for biomechanical tests

Marzio Bergomi

Mechanical testing of the periodontal ligament requires a practical experimental model. Bovine teeth are advantageous in terms of size and availability, but information is lacking as to the anatomy and histology of their periodontium. The aim of this study ...

2008