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Publication

Structural brain correlates in major depression, anxiety disorders and post-traumatic stress disorder: A voxel-based morphometry meta-analysis

Erick Jorge Canales Rodriguez
2021
Reviews

Abstract

The high comorbidity of Major Depressive Disorder (MDD), Anxiety Disorders (ANX), and Posttraumatic Stress Disorder (PTSD) has hindered the study of their structural neural correlates. The authors analyzed specific and common grey matter volume (GMV) characteristics by comparing them with healthy controls (HC). The meta-analysis of voxel-based morphometry (VBM) studies showed unique GMV diminutions for each disorder (p < 0.05, corrected) and less robust smaller GMV across diagnostics (p < 0.01, uncorrected). Pairwise comparison between the disorders showed GMV differences in MDD versus ANX and in ANX versus PTSD. These results endorse the hypothesis that unique clinical features characterizing MDD, ANX, and PTSD are also reflected by disorder specific GMV correlates.

Official source

https://infoscience.epfl.ch/entities/publication/003247b8-9bc5-45bc-bd5d-c4d7c482f416

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Erick Jorge Canales Rodriguez
2021
Reviews

Abstract

Official source

https://infoscience.epfl.ch/entities/publication/003247b8-9bc5-45bc-bd5d-c4d7c482f416

About this result

Related concepts (15)

Abnormality (behavior)

Abnormality (or dysfunctional behavior) is a behavioral characteristic assigned to those with conditions that are regarded as rare or dysfunctional. Behavior is considered to be abnormal when it is atypical or out of the ordinary, consists of undesirable behavior, and results in impairment in the individual's functioning. Abnormality in behavior, is that in which is considered deviant from specific societal, cultural and ethical expectations. These expectations are broadly dependent on age, gender, traditional and societal categorizations.

Genetic disorder

A genetic disorder is a health problem caused by one or more abnormalities in the genome. It can be caused by a mutation in a single gene (monogenic) or multiple genes (polygenic) or by a chromosomal abnormality. Although polygenic disorders are the most common, the term is mostly used when discussing disorders with a single genetic cause, either in a gene or chromosome. The mutation responsible can occur spontaneously before embryonic development (a de novo mutation), or it can be inherited from two parents who are carriers of a faulty gene (autosomal recessive inheritance) or from a parent with the disorder (autosomal dominant inheritance).

Antisocial personality disorder

Antisocial personality disorder (ASPD or APD) is a personality disorder characterized by a limited capacity for empathy and a long-term pattern of disregard or violation of the rights of others. Other notable symptoms include impulsivity and reckless behavior (including substance abuse), a lack of remorse after hurting others, deceitfulness, irresponsibility, and aggressive behavior. Symptoms of ASPD must be present before the age of 15 to receive a diagnosis.

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Structural brain correlates in major depression, anxiety disorders and post-traumatic stress disorder: A voxel-based morphometry meta-analysis

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