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Kim Do

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Related publications (57)

N-acetylcysteine add-on treatment leads to an improvement of fornix white matter integrity in early psychosis: a double-blind randomized placebo-controlled trial

Patric Hagmann, Rolf Gruetter, Lijing Xin, Alessandra Griffa, Kim Do

Mechanism-based treatments for schizophrenia are needed, and increasing evidence suggests that oxidative stress may be a target. Previous research has shown that N-acetylcysteine (NAC), an antioxidant and glutathione (GSH) precursor almost devoid of side e ...

2018

Cannabis use in early psychosis is associated with reduced glutamate levels in the prefrontal cortex

Rolf Gruetter, Lijing Xin, Kim Do

Recent studies have shown that cannabis may disrupt glutamate (Glu) signaling depressing Glu tone in frequent users. Current evidence have also consistently reported lower Glu-levels in various brain regions, particularly in the medial prefrontal cortex (m ...

Springer Verlag2018

An Add-On Trial With N-Acetyl-Cysteine (Nac) In Early Psychosis Patients: Towards Biomarker Guided Treatment

Rolf Gruetter, Lijing Xin, Kim Do

Oxford University Pres2018

Childhood Trauma Engages Oxidative Stress, Hippocampus Alterations, And Poorer Clinical Outcome In Early Psychosis Patients

Patric Hagmann, Alessandra Griffa, Kim Do

Oxford University Press2018

N-acetylcysteine in a Double-Blind Randomized Placebo-Controlled Trial: Toward Biomarker-Guided Treatment in Early Psychosis

Rolf Gruetter, Lijing Xin, Kim Do

2018

Redox Dysregulation, Oligodendrocytes And White Matter Alterations In Schizophrenia

Patric Hagmann, Lijing Xin, Alessandra Griffa, Kim Do

Oxford University Press2018

Social isolation stress and chronic glutathione deficiency have a common effect on the glutamine-to-glutamate ratio and myo-inositol concentration in the mouse frontal cortex

Rolf Gruetter, João Miguel das Neves Duarte, Alberto Corcoba, Kim Do

Environmental stress can interact with genetic predisposition to increase the risk of developing psychopathology. In this work, we tested the hypothesis that social isolation stress interacts with impaired glutathione synthesis and have cumulative effects ...

Wiley-Blackwell2017

N-Acetyl-Cysteine In A Doubleblind Randomized Placebo-Controlled Trial: Toward Biomarker-Guided Treatment In Early Psychosis

Thierry Buclin, Rolf Gruetter, Lijing Xin, Kim Do

Oxford Univ Press2017

Topological Analyses Of Metabolomic Data To Identify Markers Of Early Psychosis And Disease Biotypes

Kathryn Hess Bellwald, Martina Scolamiero, Kim Do

Oxford Univ Press2017

N-acetyl-cysteine in a double-blind randomized placebo-controlled trial: Towards biomarker guided treatment in early psychosis

Rolf Gruetter, Lijing Xin, Kim Do

Elsevier France-Editions Scientifiques Medicales Elsevier2017

Cannabis use decreases prefrontal glutamate levels in early psychosis

Rolf Gruetter, Lijing Xin, Kim Do

Elsevier France-Editions Scientifiques Medicales Elsevier2017

Redox dysregulation in schizophrenia pathophysiology: add-on trial with N-acetylcysteine (NAC) in early psychosis patients

Rolf Gruetter, Lijing Xin, Kim Do

Elsevier Science Bv2017

Genetic Polymorphism Associated Prefrontal Glutathione and Its Coupling With Brain Glutamate and Peripheral Redox Status in Early Psychosis

Rolf Gruetter, Benoît Schaller, Lijing Xin, Huanxiang Lu, Kim Do

BACKGROUND: Oxidative stress and glutathione (GSH) metabolism dysregulation has been implicated in the pathophysiology of schizophrenia. GAG-trinucleotide repeat (TNR) polymorphisms in the glutamate-cysteine ligase catalytic gene (GCLC), the rate-limiting ...

Oxford University Press2016

Glutamate Cysteine Ligase-Modulatory Subunit Knockout Mouse Shows Normal Insulin Sensitivity but Reduced Liver Glycogen Storage

Pierre Magistretti, Kim Do

Glutathione (GSH) deficits have been observed in several mental or degenerative illness, and so has the metabolic syndrome. The impact of a decreased glucose metabolism on the GSH system is well-known, but the effect of decreased GSH levels on the energy m ...

Frontiers Media Sa2016

Glutathione deficit affects the integrity and function of the fimbria/fornix and anterior commissure in mice: relevance for schizophrenia

Rolf Gruetter, João Miguel das Neves Duarte, Yohan Van de Looij, Aline Monin, Alberto Corcoba, Kim Do

BACKGROUND: Structural anomalies of white matter (WM) are found in various brain regions of patients with schizophrenia, bipolar and other psychiatric disorders, but the causes at cellular and molecular levels remain unclear. Oxidative stress and redox dys ...

Oxford Univ Press2016

N-Acetyl-Cysteine in a double-blind randomized placebo-controlled trial: Towards biomarker guided treatment in early psychosis

Rolf Gruetter, Lijing Xin, Kim Do

Wiley-Blackwell2016

Characterizing the connectome in schizophrenia with diffusion spectrum imaging

Jean-Philippe Thiran, Patric Hagmann, Alessandra Griffa, Kim Do

Schizophrenia is a complex psychiatric disorder characterized by disabling symptoms and cognitive deficit. Recent neuroimaging findings suggest that large parts of the brain are affected by the disease, and that the capacity of functional integration betwe ...

Wiley-Blackwell2015

Glutathione deficit impairs myelin maturation: relevance for white matter integrity in schizophrenia patients

Jean-Philippe Thiran, Patric Hagmann, Philipp Baumann, Rolf Gruetter, Lijing Xin, Alessandra Griffa, Aline Monin, Kim Do

Schizophrenia pathophysiology implies both abnormal redox control and dysconnectivity of the prefrontal cortex, partly related to oligodendrocyte and myelin impairments. As oligodendrocytes are highly vulnerable to altered redox state, we investigated the ...

Nature Publishing Group2015

Diffusion spectrum imaging connectomics: a biomarker for staging in psychotic disorders

Jean-Philippe Thiran, Patric Hagmann, Alessandra Griffa, Kim Do

2015

Evidence From Imaging Studies For Oxidative Stress Mechanisms In First Episode Schizophrenia

Jean-Philippe Thiran, Patric Hagmann, Rolf Gruetter, Lijing Xin, João Miguel das Neves Duarte, Alessandra Griffa, Yohan Van de Looij, Alexander Monin, Alberto Corcoba, Kim Do

Oxford Univ Press2015

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