Publications by Alexander Myasnikov

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Apoptosis controls cell fate, ensuring tissue homeostasis and promoting disease when dysregulated. The rate-limiting step in apoptosis is mitochondrial poration by the effector B cell lymphoma 2 (BCL-2) family proteins BAK and BAX, which are activated by i ...

Protein synthesis involves a critical step where messenger RNA (mRNA) and transfer RNAs (tRNAs) must move in tandem to advance the mRNA reading frame by one codon. This process, known as translocation, is catalyzed by elongation factor G (EF-G) in prokaryo ...

nvestigation of potential hosts of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is crucial to understanding future risks of spillover and spillback. SARS-CoV-2 has been reported to be transmitted from humans to various animals after req ...

The CRISPR-guided caspase (Craspase) complex is an assembly of the target-specific RNA nuclease known as Cas7-11 bound to CRISPR RNA (crRNA) and an ancillary protein known as TPR-CHAT (tetratricopeptide repeats (TPR) fused with a CHAT domain). The Craspase ...

Alexander Myasnikov

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Structural basis of BAK sequestration by MCL-1 in apoptosis

Atomic Insights Reveal Fidelity Mechanisms of Eukaryotic Protein Synthesis

Cryo-EM structures and binding of mouse and human ACE2 to SARS-CoV-2 variants of concern indicate that mutations enabling immune escape could expand host range

Structural insights into the regulation of Cas7-11 by TPR-CHAT