Publications by Yanheng Guo | EPFL Graph Search

Related publications (8)

Temperature evolution following joint loading promotes chondrogenesis by synergistic cues via calcium signaling

Dominique Pioletti, Jian Wang, Peyman Karami, Naser Nasrollahzadeh Mamaghani, Yanheng Guo

During loading of viscoelastic tissues, part of the mechanical energy is transformed into heat that can locally increase the tissue temperature, a phenomenon known as self-heating. In the framework of mechanobiology, it has been accepted that cells react a ...

eLIFE SCIENCES PUBL LTD2022

Synergetic Support of Cartilage Homeostasis via Coupled Thermal-Hydrostatic Pressure Stimuli

Yanheng Guo

Cartilage homeostasis, crucial for musculoskeletal function, is orchestrated by interconnected biophysical cues. In healthy cartilage, repetitive compressive loading not only elicits a range of mechanical stimuli but also induces a gradual transient temper ...

EPFL2024

Impact of Molecular Dynamics of Polyrotaxanes on Chondrocytes in Double-Network Supramolecular Hydrogels under Physiological Thermomechanical Stimulation

Dominique Pioletti, Yanheng Guo, Theofanis Stampoultzis, Vijay Kumar Rana

Hyaline cartilage, a soft tissue enriched with a dynamic extracellular matrix, manifests as a supramolecular system within load-bearing joints. At the same time, the challenge of cartilage repair through tissue engineering lies in replicating intricate cel ...

American Chemical Society2024

A guide to preclinical evaluation of hydrogel-based devices for treatment of cartilage lesions

Dominique Pioletti, Peyman Karami, Yanheng Guo, Theofanis Stampoultzis

The drive to develop cartilage implants for the treatment of major defects in the musculoskeletal sys-tem has resulted in a major research thrust towards developing biomaterial devices for cartilage repair. Investigational devices for the restoration of ar ...

ELSEVIER SCI LTD2023

NIR Light-Mediated Photocuring of Adhesive Hydrogels for Noninvasive Tissue Repair via Upconversion Optogenesis

Dominique Pioletti, Christophe Moser, Peyman Karami, Antoine Vincent Boniface, Yanheng Guo, Vijay Kumar Rana, Qianyi Zhang

The surgical treatments of injured soft tissues lead to further injury due to the use of sutures or the surgical routes, which need to be large enough to insert biomaterials for repair. In contrast, the use of low viscosity photopolymerizable hydrogels tha ...

American Chemical Society2022

Unraveling cartilage degeneration through synergistic effects of hydrostatic pressure and biomimetic temperature increase

Dominique Pioletti, Peyman Karami, Naser Nasrollahzadeh Mamaghani, Yanheng Guo, Theofanis Stampoultzis, Vijay Kumar Rana

Cartilage degeneration, typically viewed as an irreversible, vicious cycle, sees a significant reduction in two essential biophysical cues: the well-established hydrostatic pressure (HP) and the recently discovered transient temperature increase. Our study ...

Cell Press2023

Enhancing Robustness of Adhesive Hydrogels through PEG-NHS Incorporation

Dominique Pioletti, François Gorostidi, Yanheng Guo, Theofanis Stampoultzis, Vijay Kumar Rana, Ece Mailand

Tissue wounds are a significant challenge for the healthcare system, affecting millions globally. Current methods like suturing and stapling have limitations as they inadequately cover the wound, fail to prevent fluid leakage, and increase the risk of infe ...

Amer Chemical Soc2023

Mimicking Loading-Induced Cartilage Self-Heating in Vitro Promotes Matrix Formation in Chondrocyte-Laden Constructs with Different Mechanical Properties

Dominique Pioletti, Peyman Karami, Naser Nasrollahzadeh Mamaghani, Yanheng Guo, Theofanis Stampoultzis

Articular cartilage presents a mechanically sensitive tissue. Chondrocytes, the sole cell type residing in the tissue, perceive and react to physical cues as signals that significantly modulate their behavior. Hyaline cartilage is a connective tissue with ...

2023