Alexandra Krina Van Hall-Beauvais

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Physical interactions between proteins are essential for most biological processes governing life. However, the molecular determinants of such interactions have been challenging to understand, even as genomic, proteomic and structural data increase. This k ...

The key mRNA-binding proteins HuR and AUF1 are reported stress sensors in mammals. Intrigued by recent reports of sensitivity of these proteins to the electrophilic lipid prostaglandin A2 and other redox signals, we here examined their sensing abilities to ...

Stereotyped as a nexus of dNTP synthesis, the dual-subunit enzyme - ribonucleotide reductase (RNR) - is coming into view as a paradigm of oligomerization and moonlighting behavior. In the present issue of `omics', we discuss what makes the larger subunit o ...

Proteins control nearly every facet of life on a molecular level. Proteins are formed from linear strings of amino acids, which fold into three-dimensional structures that can enact functions. Evolution has created highly efficient proteins in diverse fold ...

The present application relates to a computer-implemented systems and methods for protein interaction design using surface fingerprints. The method comprises predicting at least one target interface site with high binding propensity, wherein, optionally, t ...

Studying electrophile signaling is marred by difficulties in parsing changes in pathway flux attributable to on-target, vis-& agrave;-vis off-target, modifications. By combining bolus dosing, knockdown, and Z- REX & mdash;a tool investigating on- target/on ...

De novo protein design explores uncharted sequence and structure space to generate novel proteins not sampled by evolution. A main challenge in de novo design involves crafting “designable” structural templates to guide the sequence searches toward adoptin ...

Alexandra Krina Van Hall-Beauvais

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De novo design of protein interactions with learned surface fingerprints

The mRNA-Binding Protein HuR Is a Kinetically-Privileged Electrophile Sensor

The more the merrier: how homo-oligomerization alters the interactome and function of ribonucleotide reductase

De novo designed proteins: a study in engineering novel folds and functions

Systems and methods for de novo design of protein interactions with learned surface fingerprints

Z-REX uncovers a bifurcation in function of Keap1 paralogs

Exploring “dark-matter” protein folds using deep learning

Machine Learning in Protein Science De Novo Design of Site-Specific Protein Binders Using Surface Fingerprints

De Novo Design of Site-specific Protein Binders Using Surface Fingerprints