Mediaspace scheduled maintenance: Aug 25, 2026 07:00 - 12:00 AM. During this time, videos will be temporarily unavailable. Check status updates.

Home

Person

Marilena Wischnewski

This person has left EPFL

About
Privacy
Disclaimer

Graph Chatbot

Related publications (4)

Page 1 of 1

Exploring the mechanisms governing nuclear cGAS localization and activity

Marilena Wischnewski

Recognition of pathogen-derived molecules through germline-encoded receptors is a fundamental principle of innate immunity. Pattern recognition receptors detect specific intracellular danger signals to trigger potent immune responses. The DNA sensor cyclic ...

EPFL2022

Interplay of cGAS with chromatin

Andrea Ablasser, Marilena Wischnewski

Recognition of DNA is an evolutionarily highly conserved mechanism of immunity. In mammals, the cGAS-STING pathway plays a central role in coupling DNA sensing to the execution of innate immune mechanisms, both in contexts of infection as well as in noninf ...

ELSEVIER SCIENCE LONDON2021

Structure of the mitochondrial import gate reveals distinct preprotein paths

Marilena Wischnewski

The translocase of the outer mitochondrial membrane (TOM) is the main entry gate for proteins(1-4). Here we use cryo-electron microscopy to report the structure of the yeast TOM core complex(5-9) at 3.8-angstrom resolution. The structure reveals the high-r ...

2019

BAF restricts cGAS on nuclear DNA to prevent innate immune activation

Beat Fierz, Mahmut Selman Sakar, Andrea Ablasser, Murat Kaynak, Kristina Makasheva, Alexiane Clara Decout, Baptiste Claude André Guey, Marilena Wischnewski

The appearance of DNA in the cytosol is perceived as a danger signal that stimulates potent immune responses through cyclic guanosine monophosphate–adenosine monophosphate synthase (cGAS). How cells regulate the activity of cGAS toward self-DNA and guard a ...

American Association for the Advancement of Science2020