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Javier De Ceballos Cerrajeria

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Related publications (4)

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"Doubly Orthogonal" Labeling of Peptides and Proteins

Jérôme Waser, Beat Fierz, Nora Guidotti, Raphaël Michel Henri Simonet-Davin, Romain Gaëtan Tessier, Javier De Ceballos Cerrajeria

Herein, we report a cysteine bioconjugation methodology for the introduction of hypervalent iodine compounds onto biomolecules. Ethynylbenziodoxolones (EBXs) engage thiols in small organic molecules and cysteine-containing peptides and proteins in a fast a ...

2019

Ethynylation of Cysteine Residues: From Peptides to Proteins in Vitro and in Living Cells

Jérôme Waser, Romain Gaëtan Tessier, Javier De Ceballos Cerrajeria, Raj Kumar Nandi

Current approaches to introduce terminal alkynes for bioorthogonal reactions into biomolecules still present limitations in terms of either reactivity, selectivity, or adduct stability. We present a method for the ethynylation of cysteine residues based on ...

Wiley-VCH Verlag GmbH2020

Cys-Cys and Cys-Lys Stapling of Unprotected Peptides Enabled by Hypervalent Iodine Reagents

Jérôme Waser, Christian Heinis, Elija Grinhagena, Gontran Sangouard, Javier De Ceballos Cerrajeria

Easy access to a wide range of structurally diverse stapled peptides is crucial for the development of inhibitors of protein-protein interactions. Herein, we report bis-functional hypervalent iodine reagents for two-component cysteine-cysteine and cysteine ...

Wiley-VCH Verlag GmbH2021

An Alternative One-Electron Oxidation Strategy to Access Hypervalent Iodine Reagents

Jérôme Waser, Marion Marie-Agnès Garreau, Javier De Ceballos Cerrajeria

In this issue of Chem, Powers and co-workers demonstrate that iodanyl radicals are the key oxidants and chain carriers in a proposed open-shell mechanism for the aerobic synthesis of hypervalent iodine compounds. ...

2019