Javier De Ceballos Cerrajeria

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Herein, we report a cysteine bioconjugation methodology for the introduction of hypervalent iodine compounds onto biomolecules. Ethynylbenziodoxolones (EBXs) engage thiols in small organic molecules and cysteine-containing peptides and proteins in a fast a ...

Current approaches to introduce terminal alkynes for bioorthogonal reactions into biomolecules still present limitations in terms of either reactivity, selectivity, or adduct stability. We present a method for the ethynylation of cysteine residues based on ...

Easy access to a wide range of structurally diverse stapled peptides is crucial for the development of inhibitors of protein-protein interactions. Herein, we report bis-functional hypervalent iodine reagents for two-component cysteine-cysteine and cysteine ...

In this issue of Chem, Powers and co-workers demonstrate that iodanyl radicals are the key oxidants and chain carriers in a proposed open-shell mechanism for the aerobic synthesis of hypervalent iodine compounds. ...

Javier De Ceballos Cerrajeria

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"Doubly Orthogonal" Labeling of Peptides and Proteins

Ethynylation of Cysteine Residues: From Peptides to Proteins in Vitro and in Living Cells

Cys-Cys and Cys-Lys Stapling of Unprotected Peptides Enabled by Hypervalent Iodine Reagents

An Alternative One-Electron Oxidation Strategy to Access Hypervalent Iodine Reagents