Pirkka-Pekka Untamo Laurila

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Disruption of mitochondrial function and protein homeostasis plays a central role in aging. However, how these processes interact and what governs their failure in aging remain poorly understood. Here, we showed that cer- amide biosynthesis controls the de ...

Age-related muscle dysfunction and sarcopenia are major causes of physical incapacitation in older adults and currently lack viable treatment strategies. Here we find that sphingolipids accumulate in mouse skeletal muscle upon aging and that both genetic a ...

Skeletal muscle displays remarkable plasticity upon exercise and is also one of the organs most affected by aging. Despite robust evidence that aging is associated with loss of fast-twitch (type II) muscle fibers, the underlying mechanisms remain to be elu ...

Duchenne muscular dystrophy (DMD) is the most common muscular dystrophy, and despite advances in genetic and pharmacological disease-modifying treatments, its management remains a major challenge. Mitochondrial dysfunction contributes to DMD, yet the mecha ...

A prerequisite for lifelong sperm production is that spermatogonial stem cells (SSCs) balance self-renewal and differentiation, yet factors required for this balance remain largely undefined. Using mouse genetics, we now demonstrate that the ubiquitously e ...

Duchenne muscular dystrophy (DMD), the most common muscular dystrophy, is a severe muscle disorder, causing muscle weakness, loss of independence, and premature death. Here, we establish the link between sphingolipids and muscular dystrophy. Transcripts of ...

Benegiamo et al. identify genetic variants of the mitochondrial supercomplex assembly factor COX7A2L in the skeletal muscle of mice and humans that promote cardiorespiratory fitness. ...

The present invention relates to an inhibitor of sphingolipids for use in the treatment or prevention of an aging related-disease and/or aging. ...

Pirkka-Pekka Untamo Laurila

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Inhibiting de novo ceramide synthesis restores mitochondrial and protein homeostasis in muscle aging

Sphingolipids accumulate in aged muscle, and their reduction counteracts sarcopenia

The exercise-induced long noncoding RNA CYTOR promotes fast-twitch myogenesis in aging

Urolithin A improves muscle function by inducing mitophagy in muscular dystrophy

Transcription Factor USF1 Is Required for Maintenance of Germline Stem Cells in Male Mice

Inhibition of sphingolipid de novo synthesis counteracts muscular dystrophy

COX7A2L genetic variants determine cardiorespiratory fitness in mice and human

Treatment and prevention of aging related-disease and/or aging by the inhibition of sphingolipids