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Francesca Pontanari

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Related publications (4)

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The Slc25a47 locus is a novel determinant of hepatic mitochondrial function implicated in liver fibrosis

Johan Auwerx, Kristina Schoonjans, Alessia Perino, Xiaoxu Li, Hao Li, Hadrien Charles Edouard Demagny, Yu Sun, Vera Monica Lemos Da Silva, Francesca Pontanari, Nadia Bresciani

Background & Aims: Transporters of the SLC25 mitochondrial carrier superfamily bridge cytoplasmic and mitochondrial metabolism by channeling metabolites across mitochondrial membranes and are pivotal for metabolic homeostasis. Despite their physiological r ...

ELSEVIER2022

Asparagine protects pericentral hepatocytes during acute liver injury

Kristina Schoonjans, Alessia Perino, Hadrien Charles Edouard Demagny, Ece Yildiz, Antoine Jalil, Yu Sun, Francesca Pontanari, Nadia Bresciani, Adrien Faure Garcia

The nonessential amino acid asparagine can only be synthesized de novo by the enzymatic activity of asparagine synthetase (ASNS). While ASNS and asparagine have been implicated in the response to numerous metabolic stressors in cultured cells, the in vivo ...

AMER SOC CLINICAL INVESTIGATION INC2023

The Slc25a47-Wars1 locus: characterization of its role in metabolic homeostasis and stress pathways

Francesca Pontanari

Our objective was to identify the metabolite transported by SLC25A47, a unique mitochondrial carrier specifically expressed in hepatocytes. To achieve this, we utilized a commercially available mouse model with a hepatocyte-specific knockout of Slc25a47. U ...

EPFL2024

Wars1 downregulation in hepatocytes induces mitochondrial stress and disrupts metabolic homeostasis

Johan Auwerx, Kristina Schoonjans, Alessia Perino, Xiaoxu Li, Giorgia Benegiamo, Hadrien Charles Edouard Demagny, Antoine Jalil, Francesca Pontanari, Adrien Faure Garcia

Several laboratories, including ours, have employed the Slc25a47tm1c(EUCOMM)Hmgu mouse model to investigate the role of SLC25A47, a hepatocyte-specific mitochondrial carrier, in regulating hepatic metabolism and systemic physiology. In this study, we revea ...

2025