Publications by Kewen Lei | EPFL Graph Search

Related publications (6)

Mechanical Immunoengineering of T-cells for Therapeutic Applications

T cells, a key component in adaptive immunity, are central to many immunotherapeutic modalities aimed at treating various diseases including cancer, infectious diseases, and autoimmune disorders. The past decade has witnessed tremendous progress in immunot ...

American Chemical Society2020

Mechanical Immunoengineering of T Cells for Enhanced Cancer Immunotherapy

Kewen Lei

Cancer is one of the leading causes of death globally. Immunotherapy represents one of the most promising cancer treatments inducing complete and durable responses in a fraction of cancer patients. Despite the unprecedented clinical success achieved by T c ...

EPFL2022

Surgery-free injectable macroscale biomaterials for local cancer immunotherapy

Li Tang, Kewen Lei

Immunotherapy can harness the power of host's immune system to fight cancer. In the last few decades, tremendous progress has been made in this field, with remarkable clinical successes achieved consisting of a durable response in a fraction of patients. H ...

2019

Cancer-cell stiffening via cholesterol depletion enhances adoptive T-cell immunotherapy

Georg Fantner, Li Tang, Mahmut Selman Sakar, Yugang Guo, Murat Kaynak, Mélanie Thérèse Marie Hannebelle, Armand Kurum, Kewen Lei, Lucia Bonati, Yuqing Xie, Min Gao, Veronika Cencen

Cancer cells enriched in cholesterol in their plasma membrane impair T-cell-mediated cytotoxicity, which can be augmented by stiffening the cancer cells via cholesterol depletion, as shown in mouse models of adoptive T-cell immunotherapy. Malignant transfo ...

2021

T cell force-responsive delivery of anticancer drugs using mesoporous silica microparticles

Li Tang, Kewen Lei

T cell-based cancer immunotherapy has achieved great success in the clinic; however, only a small fraction of patients respond to this therapy. Strategies to specifically and safely augment anticancer activity through controlled delivery of T cell supporti ...

Royal Society of Chemistry2020

A Manganese Phosphate Nanocluster Activates the cGAS‐STING Pathway for Enhanced Cancer Immunotherapy

Li Tang, Yugang Guo, Armand Kurum, Kewen Lei, Yuqing Xie, Min Gao, Yu Zhao, Xiaomeng Hu

Targeting the stimulator of interferon genes (STING) pathway with cyclic dinucleotides (CDNs), the natural STING agonists, is a promising immunotherapeutic strategy for cancer. However, the clinical application of natural CDNs as therapeutics is greatly hi ...

2021