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Arin Can Ülkü

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Related publications (38)

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Time-resolved Laser Speckle Contrast Imaging (TR-LSCI) of Cerebral Blood Flow

Edoardo Charbon, Claudio Bruschini, Arin Can Ülkü, Paul Mos

To address many of the deficiencies in optical neuroimaging technologies, such as poor tempo-spatial resolution, low penetration depth, contact-based measurement, and time-consuming image reconstruction, a novel, noncontact, portable, time-resolved laser s ...

Institute of Electrical and Electronics Engineers2024

In vitro and in vivo NIR fluorescence lifetime imaging with a time-gated SPAD camera

Edoardo Charbon, Claudio Bruschini, Arin Can Ülkü

Near-infrared (NIR) fluorescence lifetime imaging (FLI) provides a unique contrast mechanism to monitor biological parameters and molecular events in vivo. Single-photon avalanche diode (SPAD) cameras have been recently demonstrated in FLI microscopy (FLIM ...

Optica Publishing Group2022

Heralded Spectroscopy: a new single-particle probe for nanocrystal photophysics

Edoardo Charbon, Claudio Bruschini, Samuel Burri, Arin Can Ülkü, Ivan Michel Antolovic

Semiconductor nanocrystals feature multiply-excited states that display intriguing physics and significantly impact nanocrystal-based technologies. Fluorescence supplies a natural probe to investigate these states. Still, direct observation of multiexciton ...

SPIE2023

LinoSPAD2: a 512x1 linear SPAD camera with system-level 135-ps SPTR and a reconfigurable computational engine for time-resolved single-photon imaging

Edoardo Charbon, Claudio Bruschini, Samuel Burri, Arin Can Ülkü, Tommaso Milanese, Ermanno Bernasconi

The LinoSPAD2 camera combines a 512×1 linear single-photon avalanche diode (SPAD) array with an FPGA-based photon-counting and time-stamping platform, to create a reconfigurable sensing system capable of detecting single photons. The read-out is fully para ...

SPIE2023

3D fluorescence molecular tomography utilizing a novel SPAD camera

Edoardo Charbon, Claudio Bruschini, Arin Can Ülkü, Vikash Kumar Pandey

3D Fluorescence Molecular Tomography (FMT) is an important pre-clinical tool for quantifying and characterizing molecular markers for different diseases. Herein, we demonstrate, for the first time, 3D K-Space FMT reconstructions using a large time-gated SP ...

SPIE2024

Deep learning-based temporal deconvolution for photon time-of-flight distribution retrieval

Edoardo Charbon, Claudio Bruschini, Arin Can Ülkü

The acquisition of the time of flight (ToF) of photons has found numerous applications in the biomedical field. Over the last decades, a few strategies have been proposed to deconvolve the temporal instrument response function (IRF) that distorts the exper ...

2024

Massively parallel, real-time multispeckle diffuse correlation spectroscopy using a 500 × 500 SPAD camera

Edoardo Charbon, Claudio Bruschini, Arin Can Ülkü, Andrei Ardelean, Paul Mos, Michael Alan Wayne

Diffuse correlation spectroscopy (DCS) is a promising noninvasive technique for monitoring cerebral blood flow and measuring cortex functional activation tasks. Taking multiple parallel measurements has been shown to increase sensitivity, but is not easily ...

2023

Fluorescence lifetime imaging with a single-photon SPAD array using long overlapping gates: an experimental and theoretical study

Edoardo Charbon, Claudio Bruschini, Arin Can Ülkü, Andrei Ardelean

Developing large arrays of single-photon avalanche diodes (SPADs) with on-chip time-correlated single-photon counting (TCSPC) capabilities continues to be a difficult task due to stringent silicon real estate constraints, high data rates and system complex ...

2019

Single-photon avalanche diode imaging sensor for subsurface fluorescence LiDAR

Edoardo Charbon, Claudio Bruschini, Arin Can Ülkü

We realized subsurface fluorescence LiDAR with a large format single-photon avalanche diode array capable of localizing and quantifying concentration of fluorescent molecules in heavily scattering media, such as tissue, with submillimeter depth accuracy. ( ...

OPTICAL SOC AMER2021

Using Heralded Spectrometry to Measure the Biexciton Binding Energy of an Individual Quantum Dot

Edoardo Charbon, Claudio Bruschini, Samuel Burri, Arin Can Ülkü, Ivan Michel Antolovic

Spectrometry of a quantum state of light is a fundamental challenge with practical implications. Here, we demonstrate how such a technique can super-resolve the exciton and biexciton energies in a single quantum dot at room temperature. ...

Optica2022

GPU-based data processing for speeding-up correlation plenoptic imaging

Edoardo Charbon, Claudio Bruschini, Samuel Burri, Arin Can Ülkü, Paul Mos, Michael Alan Wayne

Correlation plenoptic imaging (CPI) is a novel technological imaging modality enabling to overcome drawbacks of standard plenoptic devices, while preserving their advantages. However, a major challenge in view of real-time application of CPI is related to ...

2024

Wide-field time-gated SPAD imager for phasor-based FLIM applications

Edoardo Charbon, Claudio Bruschini, Arin Can Ülkü, Ivan Michel Antolovic, Andrei Ardelean

We describe the performance of a new wide area time-gated single-photon avalanche diode (SPAD) array for phasor-FLIM, exploring the effect of gate length, gate number and signal intensity on the measured lifetime accuracy and precision. We conclude that th ...

IOP2020

Method and device for performing spectrally and temporally resolved spectroscopy of single photon emission in a quantum device

Edoardo Charbon, Claudio Bruschini, Arin Can Ülkü

A light spectrometer including a laser configured to provide for a laser pulse (12), a quantum dot (30), an objective (21) configured to focus the laser pulse (12) onto the quantum dot (30) such that a fluorescent light beam is emitted from the quantum dot ...

2023

A 500×500 Dual-Gate SPAD Imager with 100% Temporal Aperture and 1 ns Minimum Gate Width for FLIM and Phasor Imaging Applications

Edoardo Charbon, Claudio Bruschini, Arin Can Ülkü, Andrei Ardelean, Paul Mos

International Image Sensors Society2021

Temporal Point Spread Function Deconvolution in Time-resolved Fluorescence Lifetime Imaging using Deep Learning Model

Edoardo Charbon, Claudio Bruschini, Arin Can Ülkü

We report a deep RNN model for temporal point spread function (TPSFs) deconvolution in multimodal imaging systems to extract true sample fluorescence decay rate. It’s performance has been validated in phantom and well-plate data. ...

Optical Society of America2024

Monolithic SPAD Arrays for High-Performance, Time-Resolved Single-Photon Imaging

Edoardo Charbon, Claudio Bruschini, Ivan Michel Antolovic, Samuel Burri, Arin Can Ülkü, Chunmin Zhang, Scott Anthony Lindner

SPAD (single-photon avalanche diode) arrays are single-photon sensors, which enable photon counting and unparalleled time-resolved imaging. In this paper, we will detail the architecture and characteristics of three representative SPAD arrays, implemented ...

IEEE2018

Characterization of a large gated SPAD array for widefield NIR fluorescence lifetime imaging in vitro and in vivo

Edoardo Charbon, Claudio Bruschini, Arin Can Ülkü

CELL PRESS2022

Quanta Burst Photography

Edoardo Charbon, Claudio Bruschini, Arin Can Ülkü

International Image Sensors Society2021