Publications by Lixia Wei | EPFL Graph Search

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Protein Engineering, especially protein post-translational modification (PTM), ex-tends proteomes in a more complex way than one can expect from analysis of their encod-ing genomes. It can activate or deactivate certain catalytic functions, add new desired ...

The activation of the host adaptive immune system is crucial for eliminating viruses. However, influenza infection often suppresses the innate immune response that precedes adaptive immunity, and the adaptive immune responses are typically delayed. Dendrit ...

Interleukin-2 (IL-2) is a potent T-cell mitogen that can adjuvant anti-cancer adoptive T-cell transfer (ACT) immunotherapy by promoting T-cell engraftment. However, the clinical applications of IL-2 in combination with ACT are greatly hindered by the sever ...

Most viruses start their invasion by binding to glycoproteins' moieties on the cell surface (heparan sulfate proteoglycans [HSPG] or sialic acid [SA]). Antivirals mimicking these moieties multivalently are known as broad-spectrum multivalent entry inhibito ...

Protein therapeutics have enormous potential for transforming the treatment of intracellular cell disorders, such as genetic disorders and cancers. Due to proteins’ cell-membrane impermeability, protein-based drugs against intracellular targets require eff ...

Polymers when self-cross-linked into single-chain nanoparticles bear some resemblance to folded proteins; yet proteins have clear energy landscapes that determine precisely folded structures, while single-chain polymer nanoparticles (SCNPs) have more undef ...

One of the biggest threats for bacteria-based bioreactors in the biotechnology industry is infections caused by bacterial viruses called bacteriophages. More than 70% of companies admitted to encountering this problem. Despite phage infections being such a ...

A method for the diagnosis of cancer in a sample of cholesterol-rich lipoprotein nanoparticles obtained from a test subject includes: (a) determining the protein level of at least one protein in the sample of isolated cholesterol-rich lipoprotein nanoparti ...

The present invention concerns a method for producing polymers suitable as carrier-free delivery system of bioactive molecules, in particular bioactive peptides. The method comprises the polycondensation of one or more different monomers, including monomer ...

A versatile and highly effective platform remains a major challenge in the development of personalized cancer vaccines. Here, we devised a redox-responsive polycondensate neoepitope (PNE) through a reversible polycondensation reaction of peptide neoantigen ...

The present invention relates to a method for the diagnosis of cancer in a sample of cholesterol-rich lipoprotein nanoparticles obtained from a test subject comprising (α) determining the size distribution or the fractogram in chromatography of the cholest ...

The "Carbon Peaking and Carbon Neutrality" strategy of China has accelerated the process of industrial structure transformation of global energy-saving and environmental protection. With the international efforts to cope with climate change and the growing ...

Most nanoparticles' parameters affect their interactions with cells. To date, all the parameters studied are basically static (e.g., size, shape, ligands, and charge). This is unfortunate, because proteins have struc-tural dynamics that most nanoparticles ...

Lixia Wei

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Protein Engineering for Personalized therapy and diagnosis

A Synthetic Multivalent Lipopeptide Derived from Pam3CSK4 with Irreversible Influenza Inhibition and Immuno-Stimulating Effects

Redox-responsive interleukin-2 nanogel specifically and safely promotes the proliferation and memory precursor differentiation of tumor-reactive T-cells

Benzene with Alkyl Chains Is a Universal Scaffold for Multivalent Virucidal Antivirals

Efficient Direct Cytosolic Protein Delivery via Protein-Linker Co-engineering

Control and Characterization of the Compactness of Single-Chain Nanoparticles

Peptide-Grafted Nontoxic Cyclodextrins and Nanoparticles against Bacteriophage Infections

Structural Evolution Of Knowledge Network And Behavior Variation Of Knowledge Subject Driven By Emotional Behavior

Cholesterol-rich lipoprotein nanoparticles for cancer diagnosis

Polymer or polycondensate based on peptide, linker and optionally other monomers and method for preparing the same

Redox-Responsive Polycondensate Neoepitope for Enhanced Personalized Cancer Vaccine

Size distributions and fractograms of cholesterol-rich lipoprotein nanoparticles for cancer diagnosis

Analysis of the mechanism of renewable energy on energy-saving and environmental protection industry: Empirical evidence from four countries

Influence of structural dynamics on cell uptake investigated with single-chain polymeric nanoparticles