Maartje Martina Cornelia Bastings

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Extracellular vesicles (EVs) derived from various stem cell sources induce cardioprotective effects during ischemia-reperfusion injury (IRI). These have been attributed mainly to the antiapoptotic, proangiogenic, microRNA (miRNA) cargo within the stem cell ...

Lipids and nucleic acids are two of the most abundant components of our cells, and both molecules are widely used as engineering materials for nanoparticles. Here, we present a systematic study of how hydrophobic modifications can be employed to modulate t ...

Most vaccines developed today include only the antigens that best stimulate the immune system rather than the entire virus or microbe, which makes vaccine production and use safer and easier, though they lack potency to induce acceptable immunity and long- ...

Latest advances in super-resolution microscopy allow the study of subcellular features at the level of single proteins, which could lead to discoveries in fundamental biological processes, specifically in cell signaling mediated by membrane receptors. Desp ...

Peripheral CD8+ T cell tolerance is a checkpoint in both autoimmune disease and anti-cancer immunity. Despite its importance, the relationship between tolerance-induced states and other CD8+ T cell differentiation states remains unclear. Using flow cytomet ...

Nucleic acids and lipids function in close proximity in biological processes, as well as in nanoengineered constructs for therapeutic applications. As both molecules carry a rich charge profile, and frequently coexist in complex ionic solutions, the electr ...

DNA-based nanostructures are actively gaining interest as tools for biomedical and therapeutic applications following the recent development of protective coating strategies prolonging structural integrity in physiological conditions. For tailored biologic ...

Dendritic cells (DCs) are key regulators of immune responses, presenting antigen-derived peptides on major histocompatibility complexes (pMHCs) to T cells for recognition via their T cell receptors (TCRs). Despite the weak intrinsic affinity of the TCR-pMH ...

Supramolecular networks are abundantly present in nature and, like crystalline materials, often develop from an initial nucleation site, followed by growth based on directional interactions between components. Traditionally, the binding strength and direct ...

With DNA-based nanomaterials being designed for applicationsincellular environments, the need arises to accurately understand theirsurface interactions toward biological targets. As for any materialexposed to protein-rich cell culture conditions, a protein ...

First evidence of geometrical patterns and defined distances of biomolecules as fundamental parameters to regulate receptor binding and cell signaling have emerged recently. Here, we demonstrate the importance of controlled nanospacing of immunostimulatory ...

Targeting cells specifically based on receptor expression levels remains an area of active research to date. Selective binding of receptors cannot be achieved by increasing the individual binding strength, as this does not account for differing distributio ...

The elegant geometry of viruses has inspired bio-engineers to synthetically explore the self-assembly of polyhedral capsids employed to protect new cargo or change an enzymatic microenvironment. Recently, Yang and co-workers used DNA nanotechnology to revi ...

Application of protective polymer coatings to enhance the biostability of DNA-based nanomaterials (DONs) has become common practice in in vitro and in vivo experiments. While the functional effect of these coatings is obvious, a detailed molecular picture ...

Rapid identification of neutralizing molecules against new and mutating viruses is key to efficiently combating biorisk. Current binder identification techniques use a monovalent library of potential binders. Interestingly, proteins on pathogens are often ...

Numerous key biological processes rely on the concept of multivalency, where ligands achieve stable binding only upon engaging multiple receptors. These processes, like viral entry or immune synapse formation, occur on the diffusive cellular membrane. One ...

Understanding hierarchical self-assembly of biological structures requires real time measurement of the self-assembly process over a broad range of length- and timescales. The success of high-speed atomic force microscopy (HS-AFM) in imaging small scale mo ...

Supramolecular crystals arise from noncovalent interactions between macromonomers and allow for the engineering of dynamic functional materials. For two-dimensional (2D) crystals, the substrate surface can induce the formation of new polymorphs not availab ...

Super-selective multivalent ligand-receptor interactions display a signature step-like onset in binding when meeting a characteristic density of target receptors. Materials engineered for super-selective binding generally display a high number of flexible ...

Maartje Martina Cornelia Bastings

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Endothelial extracellular vesicles contain protective proteins and rescue ischemia-reperfusion injury in a human heart-on-chip

Modulating the DNA/Lipid Interface through Multivalent Hydrophobicity

Nucleic acids presenting polymer nanomaterials as vaccine adjuvants

Spatial and stoichiometric in situ analysis of biomolecular oligomerization at single-protein resolution

The CD8+ T cell tolerance checkpoint triggers a distinct differentiation state defined by protein translation defects

Interplay of the mechanical and structural properties of DNA nanostructures determines their electrostatic interactions with lipid membranes

Quantification of Strand Accessibility in Biostable DNA Origami with Single-Staple Resolution

Multivalent Presentation of TCRs on DNA Nanostructures as a Sensitive Probe for pMHC Detection

Interface flexibility controls the nucleation and growth of supramolecular networks

Stabilizing Polymer Coatings Alter the Protein Corona of DNA Origami and Can Be Engineered to Bias the Cellular Uptake

Spatially Controlled Activation of Toll-like Receptor 9 with DNA-Based Nanomaterials

Selective Integrin alpha(5)beta(1) Targeting through Spatially Constrained Multivalent DNA-Based Nanoparticles

Biotechnological Frontiers of DNA Nanomaterials Continue to Expand: Bacterial Infection using Virus-Inspired Capsids

Tailoring DNA Origami Protection: A Study of Oligolysine-PEG Coatings for Improved Colloidal, Structural, and Functional Integrity

Evolution of multivalent supramolecular assemblies of aptamers with target-defined spatial organization

Probing the importance of valency and spatial organization of immune regulator PD-1 with DNA-based nanomaterials

Significance of Receptor Mobility in Multivalent Binding on Lipid Membranes

Large‐Range HS‐AFM Imaging of DNA Self‐Assembly through In Situ Data‐Driven Control

Dynamic Surface Interactions Enable the Self-Assembly of Perfect Supramolecular Crystals

Multivalent Pattern Recognition through Control of Nano-Spacing in Low-Valency Super-Selective Materials