Publications by Tamara Maric | EPFL Graph Search

Related publications (8)

Development of novel tools for imaging of metabolic fluxes in vivo

Bioluminescent imaging is a powerful technique that enables imaging in living organisms with high sensitivity, low background signal, low cost and without the need for radioactivity. The emitted photons are produced in the oxidation reaction of luciferin c ...

EPFL2020

Real-Time Imaging and Quantification of Peptide Uptake in Vitro and in Vivo

Elena Goun, Tamara Maric, Aleksey Yevtodiyenko, Hacer Karatas, Pier Luca D'Alessandro

Peptides constitute an important class of drugs for the treatment of multiple metabolic, ontological, and neurodegenerative diseases, and several hundred novel therapeutic peptides are currently in the preclinical and clinical stages of development. Howeve ...

AMER CHEMICAL SOC2019

A bioluminescent-based probe for in vivo non-invasive monitoring of nicotinamide riboside uptake reveals a link between metastasis and NAD plus metabolism

Ekaterina Solodnikova, Elena Goun, Arkadiy Bazhin, Pavlo Khodakivskyi, Tamara Maric, Aleksey Yevtodiyenko, Georgy Mikhaylov

Nicotinamide riboside (NR) is a form of vitamin B3 and is one of the most studied compounds for the restoration of cellular NAD+ levels demonstrating clinical potential in many metabolic and age-related disorders. Despite its wide commercial availability a ...

ELSEVIER ADVANCED TECHNOLOGY2023

A bioluminescent probe for longitudinal monitoring of mitochondrial membrane potential

Elena Goun, Riccardo Sinisi, Arkadiy Bazhin, Tamara Maric, Ghyslain Martial Alain Budin

Mitochondrial membrane potential (Delta Psi(m)) is a universal selective indicator of mitochondrial function and is known to play a central role in many human pathologies, such as diabetes mellitus, cancer and Alzheimer's and Parkinson's diseases. Here, we ...

NATURE RESEARCH2020

Bioluminescent-based imaging and quantification of glucose uptake in vivo

Elena Goun, Riccardo Sinisi, Arkadiy Bazhin, Pavlo Khodakivskyi, Tamara Maric, Aleksey Yevtodiyenko, Georgy Mikhaylov

Glucose is a major source of energy for most living organisms, and its aberrant uptake is linked to many pathological conditions. However, our understanding of disease-associated glucose flux is limited owing to the lack of robust tools. To date, positron- ...

NATURE PUBLISHING GROUP2019

Portable bioluminescent platform for in vivo monitoring of biological processes in non-transgenic animals

Elena Goun, Aurélien Godinat, Arkadiy Bazhin, Pavlo Khodakivskyi, Tamara Maric, Aleksey Yevtodiyenko, Ghyslain Martial Alain Budin

Bioluminescent imaging (BLI) is one of the most powerful and widely used preclinical imaging modalities. However, the current technology relies on the use of transgenic luciferase-expressing cells and animals and therefore can only be applied to a limited ...

Nature Research2021

Development of Selective FXIa Inhibitors Based on Cyclic Peptides and Their Application for Safe Anticoagulation

Christina Lamers, Rakesh Mukherjee, Christian Heinis, Xudong Kong, Kaycie Marie Butler, Vanessa Carle, Tamara Maric, Cristina Diaz Perlas, Camille Villequey, Chloé Rogg

Coagulation factor XI (FXI) has emerged as a promising target for the development of safer anticoagulation drugs that limit the risk of severe and life-threatening bleeding. Herein, we report the first cyclic peptide-based FXI inhibitor that selectively an ...

2021

Phage Display Selected Cyclic Peptide Inhibitors of Kallikrein-Related Peptidases 5 and 7 and Their In Vivo Delivery to the Skin

Hitesh Verma, Christian Heinis, Luc Reymond, Alessandro Zorzi, Vanessa Carle, Tamara Maric, Patrick Andreas Gonschorek, Mischa Schüttel

Kallikrein-related peptidases 5 (KLK5) and 7 (KLK7) are serine proteases with homeostatic functions in the epidermis that play a critical role in Netherton syndrome (NS), a rare yet life-threatening genetic disorder that currently lacks specific treatment. ...

AMER CHEMICAL SOC2022