Publications by Che Yang | EPFL Graph Search

Related publications (11)

Rosetta FunFolDes - A general framework for the computational design of functional proteins

Bruno Emanuel Ferreira De Sousa Correia, Jaume Bonet Martinez, Stéphane Rosset, Fabian Sesterhenn, Andreas Scheck, Sarah Wehrle, Che Yang, Freyr Sverrisson, Sabrina Susan Vollers, Mélanie Evelyne Villard

The robust computational design of functional proteins has the potential to deeply impact translational research and broaden our understanding of the determinants of protein function and stability. The low success rates of computational design protocols an ...

2018

Functional de novo Protein Design for Targeted Vaccines and Synthetic Biology Applications

Che Yang

Evolution has created, selected and evolved large repertoires of proteins that operate in various biological systems. Nowadays biotechnological needs are coming up orders of magnitude faster than proteins naturally evolve. The emergence of de novo protein ...

EPFL2020

A generic framework for hierarchical de novo protein design

Bruno Emanuel Ferreira De Sousa Correia, Jaume Bonet Martinez, Zander Harteveld, Fabian Sesterhenn, Stéphane Rosset, Che Yang

De novo protein design enables the exploration of novel sequences and structures absent from the natural protein universe. De novo design also stands as a stringent test for our understanding of the underlying physical principles of protein folding and may ...

National Academy of Sciences2022

Assessing and enhancing foldability in designed proteins

Bruno Emanuel Ferreira De Sousa Correia, Stéphane Rosset, Che Yang

Recent advances in protein-design methodology have led to a dramatic increase in reliability and scale. With these advances, dozens and even thousands of designed proteins are automatically generated and screened. Nevertheless, the success rate, particular ...

WILEY2022

De novo protein design enables the precise induction of RSV-neutralizing antibodies

Bruno Emanuel Ferreira De Sousa Correia, Luciano Andres Abriata, Elisa Oricchio, Jaume Bonet Martinez, Sandrine Madeleine Suzanne Georgeon, Stéphane Rosset, Fabian Sesterhenn, Che Yang, Sabrina Susan Vollers, Elie Charles Eugène Dheilly, Patricia Corthésy Henrioud, Mélanie Evelyne Villard

De novo protein design has been successful in expanding the natural protein repertoire. However, most de novo proteins lack biological function, presenting a major methodological challenge. In vaccinology, the induction of precise antibody responses remain ...

American Association for the Advancement of Science2020

Boosting subdominant neutralizing antibody responses with a computationally designed epitope-focused immunogen

Bruno Emanuel Ferreira De Sousa Correia, Jaume Bonet Martinez, Pablo Gainza Cirauqui, Fabian Sesterhenn, Stéphane Rosset, Che Yang, Patricia Corthésy Henrioud, Sabrina Susan Vollers

Throughout the last several decades, vaccination has been key to prevent and eradicate infectious diseases. However, many pathogens (e.g., respiratory syncytial virus [RSV], influenza, dengue, and others) have resisted vaccine development efforts, largely ...

2019

Bottom-up de novo design of functional proteins with complex structural features

Bruno Emanuel Ferreira De Sousa Correia, Luciano Andres Abriata, Jaume Bonet Martinez, Sandrine Madeleine Suzanne Georgeon, Stéphane Rosset, Fabian Sesterhenn, Leo Scheller, Che Yang

De novo protein design has enabled the creation of new protein structures. However, the design of functional proteins has proved challenging, in part due to the difficulty of transplanting structurally complex functional sites to available protein structur ...

2021

Epitope Mapping and Fine Specificity of Human T and B Cell Responses for Novel Candidate Blood-Stage Malaria Vaccine P27A

Bruno Emanuel Ferreira De Sousa Correia, Che Yang

P27A is a novel synthetic malaria vaccine candidate derived from the blood stage Plasmodium falciparum protein Trophozoite Exported Protein 1 (TEX1/PFF0165c). In phase 1a/1b clinical trials in malaria unexposed adults in Switzerland and in malaria pre-expo ...

2020

Computational design of bioactive protein switches with multi-logics for cell-based therapeutics

Bruno Emanuel Ferreira De Sousa Correia, Pablo Gainza Cirauqui, Leo Scheller, Che Yang, Sailan Shui

WILEY2021

Driving Immune Responses with Synthetic Proteins - Development of De Novo Designed Immunogens to Elicit Respiratory Syncytial Virus Neutralizing Antibodies

Bruno Emanuel Ferreira De Sousa Correia, Jaume Bonet Martinez, Stéphane Rosset, Fabian Sesterhenn, Che Yang, Patricia Corthésy Henrioud

WILEY2018

Immunogen

Bruno Emanuel Ferreira De Sousa Correia, Jaume Bonet Martinez, Fabian Sesterhenn, Che Yang

Polypeptides useful in the preparation of vaccine compositions against RSV are provided. Also disclosed are methods of enhancing subdominant antibody responses in a subject. ...

2020