Raphaël Michel Henri Simonet-Davin

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Herein, we report a cysteine bioconjugation methodology for the introduction of hypervalent iodine compounds onto biomolecules. Ethynylbenziodoxolones (EBXs) engage thiols in small organic molecules and cysteine-containing peptides and proteins in a fast a ...

The goal of my PhD was the development of a new method for unselective surface labeling, not substrate-specific, that would give access to direct visualization of any surface interactions. In order to achieve this challenging goal, we wanted to develop a g ...

The generation of benzylic radicals through hydrogen atom abstraction (HAT) has been a recent research focus and various C(sp(3))-H bond functionalization protocols have been developed relying on this elementary step. We report herein copper- and iron-cata ...

A methodology for the C-H azidation of N-terminal proline-containing peptides was developed employing only commercially available reagents. Peptides bearing a broad range of functionalities and containing up to 6 amino acids were selectively azidated at th ...

Raphaël Michel Henri Simonet-Davin

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"Doubly Orthogonal" Labeling of Peptides and Proteins

Azide-Containing Hypervalent Iodine Reagents for Biomolecules Functionalization

Benzylic C(sp3)-H Azidation: Copper vs Iron Catalysis

N-Terminal Selective C-H Azidation of Proline-Containing Peptides: a Platform for Late-Stage Diversification

1‐Azido‐3,3‐dimethyl‐3‐(1H )‐1,2‐benziodoxole