Publications by Katia Galan | EPFL Graph Search

Related publications (13)

Recovery of walking after paralysis by regenerating characterized neurons to their natural target region

Grégoire Courtine, Bernard Schneider, Jocelyne Bloch, Quentin Barraud, Jordan Squair, Claudia Kathe, Matthieu Pierre Gautier, Katia Galan, Mark Andrew Anderson, Newton Cho, Nicholas David James, Thomas Haynes Hutson, Laetitia Danielle Philippine Baud, Michael Alexander Skinnider, Achilleas Laskaratos, Marco Milano, Steven Lee Ceto, Anna Lasne

Axon regeneration can be induced across anatomically complete spinal cord injury (SCI), but robust functional restoration has been elusive. Whether restoring neurological functions requires directed regeneration of axons from specific neuronal subpopulatio ...

American Association for the Advancement of Science2023

A soft, scalable and adaptable multi-contact cuff electrode for targeted peripheral nerve modulation

Olivier Didier Christian Rizzo, Silvestro Micera, Stéphanie Lacour, Florian Dylan Fallegger, Ivan Furfaro, Katia Galan, Valentina Marie Paggi

Background: Cuff electrodes target various nerves throughout the body, providing neuromodulation therapies for motor, sensory, or autonomic disorders. However, when using standard, thick silicone cuffs, fabricated in discrete circular sizes, complications ...

2024

Hypothalamic deep brain stimulation augments walking after spinal cord injury

Nadia Bérard, Michael Hodara, Kristina Sveistyte, Anna Leonhartsberger, Grégoire Courtine, Jocelyne Bloch, Quentin Barraud, Léonie Asboth, Robin Jonathan Demesmaeker, Claudia Kathe, Matthieu Pierre Gautier, Katia Galan, Mark Andrew Anderson, Newton Cho, Nicholas David James, Thomas Haynes Hutson, Jimmy James Ravier, Laetitia Danielle Philippine Baud, Kay Alexander Bartholdi, Achilleas Laskaratos, Camille Claire Varescon, Nicolas Hankov, Inssia Dewany, Nadine Intering, Viviana Aureli, Frédéric Norbert Merlos

A spinal cord injury (SCI) disrupts the neuronal projections from the brain to the region of the spinal cord that produces walking, leading to various degrees of paralysis. Here, we aimed to identify brain regions that steer the recovery of walking after i ...

NATURE PORTFOLIO2024

The neurons that restore walking after paralysis

Ruijia Wang, Stéphanie Lacour, Grégoire Courtine, Jocelyne Bloch, Quentin Barraud, Jordan Squair, Léonie Asboth, Fabien Bertrand Paul Wagner, Robin Jonathan Demesmaeker, Claudia Kathe, Matthieu Pierre Gautier, Kyungjin Kim, Katia Galan, Newton Cho, Nicholas David James, Thomas Haynes Hutson, Salif Axel Komi, Laetitia Danielle Philippine Baud, Andreas Rowald, Steven Lee Ceto, Nicola Aldo Regazzi

A spinal cord injury interrupts pathways from the brain and brainstem that project to the lumbar spinal cord, leading to paralysis. Here we show that spatiotemporal epidural electrical stimulation (EES) of the lumbar spinal cord(1-3) applied during neurore ...

NATURE PORTFOLIO2022

Treatment with Evasin-3 reduces atherosclerotic vulnerability for ischemic stroke, but not brain injury in mice

Nikolaos Stergiopoulos, Katia Galan, Jean-Christophe Copin

Neutrophilic inflammation might have a pathophysiological role in both carotid plaque rupture and ischemic stroke injury. Here, we investigated the potential benefits of the CXC chemokine-binding protein Evasin-3, which potently inhibits chemokine bioactiv ...

Nature Publishing Group2013

Nicotinamide phosphoribosyltransferase inhibition reduces intraplaque CXCL1 production and associated neutrophil infiltration in atherosclerotic mice

Nikolaos Stergiopoulos, Rafaela Fernandes Da Silva, Katia Galan

Pharmacological treatments targeting CXC chemokines and the associated neutrophil activation and recruitment into atherosclerotic plaques hold promise for treating cardiovascular disorders. Therefore, we investigated whether FK866, a nicotinamide phosphori ...

Schattauer2014

Epineural optogenetic activation of nociceptors initiates and amplifies inflammation

Stéphanie Lacour, Ivan Furfaro, Outman Akouissi, Katia Galan, Frédéric Pierre Gérald Michoud

Activation of nociceptor sensory neurons by noxious stimuli both triggers pain and increases capillary permeability and blood flow to produce neurogenic inflammation(1,2), but whether nociceptors also interact with the immune system remains poorly understo ...

NATURE RESEARCH2020

Epidural electrical stimulation of the cervical dorsal roots restores voluntary upper limb control in paralyzed monkeys

Stéphanie Lacour, Grégoire Courtine, Jocelyne Bloch, Giuseppe Schiavone, Florian Dylan Fallegger, Quentin Barraud, Tomislav Milekovic, Katia Galan, Nicholas David James

Regaining arm control is a top priority for people with paralysis. Unfortunately, the complexity of the neural mechanisms underlying arm control has limited the effectiveness of neurotechnology approaches. Here, we exploited the neural function of survivin ...

NATURE PORTFOLIO2022

Movement Initiation Signals in Mouse Whisker Motor Cortex

Carl Petersen, Sylvain Crochet, Katia Galan, Varun Sreenivasan, Vahid Esmaeili, Taro Kiritani

Frontal cortex plays a central role in the control of voluntary movements, which are typically guided by sensory input. Here, we investigate the function of mouse whisker primary motor cortex (wM1), a frontal region defined by dense innervation from whiske ...

Cell Press2016

Treatment with Angiotensin-(1-7) reduces inflammation in carotid atherosclerotic plaques

Nikolaos Stergiopoulos, Rafaela Fernandes Da Silva, Katia Galan

Angiotensin (Ang)-(1-7), acting through the receptor Mas, has athero-protective effects; however, its role on plaque vulnerability has been poorly studied. Here, we investigated the expression of the renin-angiotensin system (RAS) components in stable and ...

Schattauer2014

The selective pharmacologic inhibition of CXC chemokines is associated with an improvement of histological features of vulnerability in mouse atherosclerotic plaques

Nikolaos Stergiopoulos, Rafaela Fernandes Da Silva, Katia Galan

Wiley-Blackwell2013

The activation of the cannabinoid receptor type 2 reduces neutrophilic protease-mediated vulnerability in atherosclerotic plaques

Nikolaos Stergiopoulos, Rafaela Fernandes Da Silva, Katia Galan

The activation of cannabinoid receptor type 2 (CB2)-mediated pathways might represent a promising anti-atherosclerotic treatment. Here, we investigated the expression of the endocannabinoid system in human carotid plaques and the impact of CB2 pharmacologi ...

Oxford University Press2012

Treatment with chemokine-binding protein Evasin-3 reduces atherosclerotic vulnerability for ischemic stroke in mice

Nikolaos Stergiopoulos, Rafaela Fernandes Da Silva, Katia Galan

Academic Press Ltd- Elsevier Science Ltd2012