Publications by Bruno Torchia | EPFL Graph Search

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Dendritic cells (DCs) are antigen-presenting myeloid cells that regulate T cell activation, trafficking and function. Monocyte-derived DCs pulsed with tumor antigens have been tested extensively for therapeutic vaccination in cancer, with mixed clinical re ...

Immune checkpoint blockade (ICB) with PD-1 or PD-L1 antibodies has been approved for the treatment of nonsmall cell lung cancer (NSCLC). However, only a minority of patients respond, and sustained remissions are rare. Both chemotherapy and antiangiogenic d ...

Extracellular vesicles (EVs), including exosomes, modulate multiple aspects of cancer biology. Tumor-associated macrophages (TAMs) secrete EVs, but their molecular features and functions are poorly characterized. Here, we report methodology for the enrichm ...

Bruno Torchia

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Cytokine-armed dendritic cell progenitors for antigen-agnostic cancer immunotherapy

Overcoming microenvironmental resistance to PD-1 blockade in genetically engineered lung cancer models

Molecular Profiling and Functional Analysis of Macrophage-Derived Tumor Extracellular Vesicles

Basophils inhibit tumors by suppressing Tregs

Determinants of tumor resistance to anti-angiogenic immunotherapy in mouse models of Kras-mutant NSCLC