Publications by Alessia Perino

Related publications (30)

TGR5 reduces macrophage migration through mTOR-induced C/EBP beta differential translation

Kristina Schoonjans, Mitsunori Nomura, Thijs Pols, Alessia Perino

The bile acid-responsive G protein-coupled receptor TGR5 is involved in several metabolic processes, and recent studies suggest that TGR5 activation may promote pathways that are protective against diet-induced diabetes. Here, we investigated the role of m ...

American Society for Clinical Investigation2014

Integrative systems analysis identifies genetic and dietary modulators of bile acid homeostasis

Kristina Schoonjans, Johan Auwerx, Alexis Maximilien Bachmann, Maroun Bou Sleiman, Alessia Perino, Amir Banaei Esfahani, Karim Laurent Gariani, Giacomo Vincenzo Giorgio Von Alvensleben, Hao Li, Qingyao Huang, Laura Alejandra Velazquez Villegas, Yu Sun, Xiaoxu Li, Ludger Jan Elzuë Goeminne, Jéromine Imbach

Bile acids (BAs) are complex and incompletely understood enterohepatic-derived hormones that control whole-body metabolism. Here, we profiled postprandial BAs in the liver, feces, and plasma of 360 chowor high-fat-diet-fed BXD male mice and demonstrated th ...

Cell Press2022

Bile acid 7α-dehydroxylating bacteria accelerate injury-induced mucosal healing in the colon

Rizlan Bernier-Latmani, Kristina Schoonjans, Alessia Perino, Hadrien Charles Edouard Demagny, Eduard Vico Oton, Colin Volet, Antoine Jalil, Jéromine Imbach, Lucie Plantade

Host-microbiome communication is frequently perturbed in gut pathologies due to microbiome dysbiosis, leading to altered production of bacterial metabolites. Among these, 7 alpha-dehydroxylated bile acids are notably diminished in inflammatory bowel diseas ...

SPRINGERNATURE2025

Identification of a Crosstalk among TGR5, GLIS2, and TP53 Signaling Pathways in the Control of Undifferentiated Germ Cell Homeostasis and Chemoresistance

Kristina Schoonjans, Alessia Perino

Spermatogonial stem cells regenerate and maintain spermatogenesis throughout life, making testis a good model for studying stem cell biology. The effects of chemotherapy on fertility have been well-documented previously. This study investigates how busulfa ...

WILEY2022

Genetic and dietary modulators of the inflammatory response in the gastrointestinal tract of the BXD mouse genetic reference population

Jonathan Allen Sulc, Alexis Rapin, Kristina Schoonjans, Johan Auwerx, Alexis Maximilien Bachmann, Maroun Bou Sleiman, Alessia Perino, Giorgia Benegiamo, Jean-David Horacio Morel, Xiaoxu Li, Johanne Gracia Anne Poisson

Inflammatory gut disorders, including inflammatory bowel disease (IBD), can be impacted by dietary, environmental, and genetic factors. While the incidence of IBD is increasing worldwide, we still lack a complete understanding of the gene-by-environment in ...

2023

Inhibiting poly ADP-ribosylation increases fatty acid oxidation and protects against fatty liver disease

Elena Katsyuba, Kristina Schoonjans, Johan Auwerx, Dongryeol Ryu, Hongbo Zhang, Keir Joe Menzies, Alessia Perino, Karim Laurent Gariani, Vera Monica Lemos Da Silva, Pooja Jha, Jun Yong Kim

Background & Aims: To date, no pharmacological therapy has been approved for non-alcoholic fatty liver disease (NAFLD). The aim of the present study was to evaluate the therapeutic potential of poly ADP-ribose polymerase (PARP) inhibitors in mouse models o ...

Elsevier Science Bv2017

Metabolic Messengers: bile acids

Kristina Schoonjans, Alessia Perino

Bile acids (BAs) are amphipathic steroid acids whose production and diversity depend on both host and microbial metabolism. These metabolites have emerged as biologically active signalling molecules that inform organs of nutrient availability. Their action ...

2022

The Slc25a47 locus is a novel determinant of hepatic mitochondrial function implicated in liver fibrosis

Kristina Schoonjans, Johan Auwerx, Alessia Perino, Vera Monica Lemos Da Silva, Hao Li, Hadrien Charles Edouard Demagny, Francesca Pontanari, Nadia Bresciani, Yu Sun, Xiaoxu Li

Background & Aims: Transporters of the SLC25 mitochondrial carrier superfamily bridge cytoplasmic and mitochondrial metabolism by channeling metabolites across mitochondrial membranes and are pivotal for metabolic homeostasis. Despite their physiological r ...

ELSEVIER2022

Porphyran from discolored nori prevents metabolic syndrome through microbiota-bile acid-ceramide pathway

Johan Auwerx, Adrienne Joëlle Laurence Mottis, Alessia Perino, Jean-David Horacio Morel

Nori is a component of the traditional Japanese diet. The Japanese have a low prevalence of obesity and cardiovascular disease worldwide, and components of nori may have disease-preventive effects. Here, we focused on porphyran, which is abundant in nori t ...

2025

Asparagine protects pericentral hepatocytes during acute liver injury

Kristina Schoonjans, Alessia Perino, Ece Yildiz, Hadrien Charles Edouard Demagny, Francesca Pontanari, Nadia Bresciani, Yu Sun, Adrien Faure Garcia, Antoine Jalil

The nonessential amino acid asparagine can only be synthesized de novo by the enzymatic activity of asparagine synthetase (ASNS). While ASNS and asparagine have been implicated in the response to numerous metabolic stressors in cultured cells, the in vivo ...

AMER SOC CLINICAL INVESTIGATION INC2023

Bile acids deoxycholic acid and ursodeoxycholic acid differentially regulate human beta-defensin-1 and-2 secretion by colonic epithelial cells

Kristina Schoonjans, Alessia Perino

Bile acids and epithelial-derived human beta-defensins (H beta Ds) are known to be important factors in the regulation of colonic mucosal barrier function and inflammation. We hypothesized that bile acids regulate colonic H beta D expression and aimed to t ...

Federation of American Society of Experimental Biology2017

Bile Acids Signal via TGR5 to Activate Intestinal Stem Cells and Epithelial Regeneration

Kristina Schoonjans, Maroun Bou Sleiman, Alessia Perino, Ece Yildiz, Giovanni Sorrentino, Gaby El Alam

BACKGROUND & AIMS: Renewal and patterning of the intestinal epithelium is coordinated by intestinal stem cells (ISCs); dietary and metabolic factors provide signals to the niche that control ISC activity. Bile acids (BAs), metabolites in the gut, signal nu ...

2020

SIRT2 Deficiency Modulates Macrophage Polarization and Susceptibility to Experimental Colitis

Kristina Schoonjans, Johan Auwerx, Hiroyasu Yamamoto, Adrienne Joëlle Laurence Mottis, Giuseppe Lo Sasso, Alessandra Piersigilli, Keir Joe Menzies, Alessia Perino

Background: SIRT2 belongs to a highly conserved family of NAD(+)-dependent deacylases, consisting of seven members (SIRT1-SIRT7), which vary in subcellular localizations and have substrates ranging from histones to transcription factors and enzymes. Recent ...

Public Library of Science2014

Hepatic lipid overload triggers biliary epithelial cell activation via E2Fs

Kristina Schoonjans, Johan Auwerx, Alessia Perino, Ece Yildiz, Giovanni Sorrentino, Gaby El Alam, Antoine Jalil

During severe or chronic hepatic injury, biliary epithelial cells (BECs) undergo rapid activation into proliferating progenitors, a crucial step required to establish a regenerative process known as ductular reaction (DR). While DR is a hallmark of chronic ...

eLIFE SCIENCES PUBL LTD2023

Central anorexigenic actions of bile acids are mediated by TGR5

Kristina Schoonjans, Alessia Perino, Qingyao Huang, Laura Alejandra Velazquez Villegas, Nadia Bresciani, Yu Sun

Bile acids (BAs) are signalling molecules that mediate various cellular responses in both physiological and pathological processes. Several studies report that BAs can be detected in the brain, yet their physiological role in the central nervous system is ...

2021

Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance

Kristina Schoonjans, Alessia Perino

The systemic expression of the bile acid (BA) sensor farnesoid X receptor (FXR) has led to promising new therapies targeting cholesterol metabolism, triglyceride production, hepatic steatosis and biliary cholestasis. In contrast to systemic therapy, bile a ...

Nature Publishing Group2015

SUMOylation-Dependent LRH-1/PROX1 Interaction Promotes Atherosclerosis by Decreasing Hepatic Reverse Cholesterol Transport

Kristina Schoonjans, Chikage Mataki, Dongryeol Ryu, Maaike Hélène Oosterveer, Pan Xu, Keir Joe Menzies, Alessia Perino, Xu Wang, Vera Monica Lemos Da Silva

Reverse cholesterol transport (RCT) is an antiatherogenic process in which excessive cholesterol from peripheral tissues is transported to the liver and finally excreted from the body via the bile. The nuclear receptor liver receptor homolog 1 (LRH-1) driv ...

Cell Press2014

Wars1 downregulation in hepatocytes induces mitochondrial stress and disrupts metabolic homeostasis

Kristina Schoonjans, Johan Auwerx, Alessia Perino, Hadrien Charles Edouard Demagny, Francesca Pontanari, Giorgia Benegiamo, Xiaoxu Li, Adrien Faure Garcia, Antoine Jalil

Several laboratories, including ours, have employed the Slc25a47tm1c(EUCOMM)Hmgu mouse model to investigate the role of SLC25A47, a hepatocyte-specific mitochondrial carrier, in regulating hepatic metabolism and systemic physiology. In this study, we revea ...

2025

Another Shp on the Horizon for Bile Acids

Kristina Schoonjans, Alessia Perino

Bile acid metabolism is tightly controlled due to the toxic effects of bile acid overload. In this issue, research from the Feng lab reports Shp2 as a novel integrator of hepatic bile acid and FGF15/FGF19 signaling, adding another layer of complexity to th ...

Cell Press2014

Farnesoid X receptor inhibits glucagon-like peptide-1 production by enteroendocrine L cells

Kristina Schoonjans, Alessia Perino

Bile acids are signalling molecules, which activate the transmembrane receptor TGR5 and the nuclear receptor FXR. BA sequestrants (BAS) complex bile acids in the intestinal lumen and decrease intestinal FXR activity. The BAS-BA complex also induces glucago ...

Nature Publishing Group2015