Alessandra Piersigilli

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Related publications (23)

SIRT2 Deficiency Modulates Macrophage Polarization and Susceptibility to Experimental Colitis

Kristina Schoonjans, Johan Auwerx, Hiroyasu Yamamoto, Adrienne Joëlle Laurence Mottis, Giuseppe Lo Sasso, Alessandra Piersigilli, Keir Joe Menzies, Alessia Perino

Background: SIRT2 belongs to a highly conserved family of NAD(+)-dependent deacylases, consisting of seven members (SIRT1-SIRT7), which vary in subcellular localizations and have substrates ranging from histones to transcription factors and enzymes. Recent ...

Public Library of Science2014

Loss of Sirt1 function improves intestinal anti-bacterial defense and protects from colitis-induced colorectal cancer

Elena Katsyuba, Kristina Schoonjans, Johan Auwerx, Dongryeol Ryu, Laurent Mouchiroud, Giuseppe Lo Sasso, Alessandra Piersigilli

Dysfunction of Paneth and goblet cells in the intestine contributes to inflammatory bowel disease (IBD) and colitis-associated colorectal cancer (CAC). Here, we report a role for the NAD+-dependent histone deacetylase SIRT1 in the control of anti-bacterial ...

Public Library of Science2014

Antibodies Trap Tissue Migrating Helminth Larvae and Prevent Tissue Damage by Driving IL-4Rα-Independent Alternative Differentiation of Macrophages

Fei Chen, Arne Seitz, Ilaria Mosconi, Nicola Harris, Julia Esser-von Bieren, Romain Guiet, Beatrice Volpe, Alessandra Piersigilli

Approximately one-third of the world's population suffers from chronic helminth infections with no effective vaccines currently available. Antibodies and alternatively activated macrophages (AAM) form crucial components of protective immunity against chall ...

Public Library of Science2013

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