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Laura Kolb

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Related publications (5)

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Stem cell niche engineering through photopatterning and microfluidics

Laura Kolb

The application of stem cells in drug screening and regenerative therapy has led to important advances in basic biology and biomedicine. Such strategies require high cell numbers and the efficient maturation into faithful functional organ or tissue units. ...

EPFL2016

Microscale patterning of hydrogel stiffness through light-triggered uncaging of thiols

Matthias Lütolf, Katarzyna Mosiewicz, Laura Kolb

Mammalian cell behavior is strongly influenced by physical and chemical cues originating from the extracellular matrix (ECM). In vivo, ECM signals are displayed in a spatiotemporally complex fashion, often composed as gradients and in concentration profile ...

Royal Soc Chemistry2014

In situ cell manipulation through enzymatic hydrogel photopatterning

Jeffrey Alan Hubbell, Matthias Lütolf, Katarzyna Mosiewicz, Laura Kolb

The physicochemical properties of hydrogels can be manipulated in both space and time through the controlled application of a light beam. However, methods for hydrogel photopatterning either fail to maintain the bioactivity of fragile proteins and are thus ...

Nature Publishing Group2013

Cell-Instructive Microgels with Tailor-Made Physicochemical Properties

Matthias Lütolf, Simone Allazetta, Laura Kolb

A microfluidic in vitro cell encapsulation platform to systematically test the effects of microenvironmental parameters on cell fate in 3D is developed. Multiple cell types including fibroblasts, embryonic stem cells, and cancer cells are incorporated in e ...

Wiley-V C H Verlag Gmbh2015

High-throughput stem cell-based phenotypic screening through microniches

Matthias Lütolf, Simone Allazetta, Mehmet Ugur Girgin, Laura Kolb

As the field of tissue engineering develops, methods for screening combinations of signals for their effects on stem cell behavior are needed. We introduce a microgel-based screening platform for testing combinations of in situ-generated proteins on stem c ...

ROYAL SOC CHEMISTRY2019