Publications by Quentin Barraud

Related publications (27)

Early intensive rehabilitation reverses locomotor disruption, decrease brain inflammation and induces neuroplasticity following experimental Cerebral Palsy

Grégoire Courtine, Yohan Van de Looij, Quentin Barraud, Laetitia Danielle Philippine Baud

Background: Cerebral Palsy (CP) is a major cause of motor and cognitive disability in children due to injury to the developing brain. Early intensive sensorimotor rehabilitation has been shown to change brain structure and reduce CP symptoms severity. We c ...

ACADEMIC PRESS INC ELSEVIER SCIENCE2024

Longitudinal interrogation of sympathetic neural circuits and hemodynamics in preclinical models

Victor Perez Puchalt, Jan Elaine Cuevas Soriano, Grégoire Courtine, Quentin Barraud, Jordan Squair, Matthieu Pierre Gautier, Loïs Thomas Romain Mahe, Rémi Bernard René Hudelle, Suje Amir

Neurological disorders, including spinal cord injury, result in hemodynamic instability due to the disruption of supraspinal projections to the sympathetic circuits located in the spinal cord. We recently developed a preclinical model that allows the ident ...

NATURE PORTFOLIO2022

Introducing a biomimetic coating for graphene neuroelectronics: toward in-vivo applications

Grégoire Courtine, Quentin Barraud, Marco Bonizzato, Elodie Rey

Electronic micro and nano-devices are suitable tools to monitor the activity of many individual neurons over mesoscale networks. However the inorganic materials currently used in microelectronics are barely accepted by neural cells and tissues, thus limiti ...

IOP PUBLISHING LTD2021

Neuroprosthetic baroreflex controls haemodynamics after spinal cord injury

Stéphanie Lacour, Grégoire Courtine, Marco Capogrosso, Jocelyne Bloch, Giuseppe Schiavone, Florian Dylan Fallegger, Nicolas Vachicouras, Quentin Barraud, Jordan Squair, Ileana Ozana Jelescu, Eduardo Martin Moraud, Fabien Bertrand Paul Wagner, Robin Jonathan Demesmaeker, Claudia Kathe, Matthieu Pierre Gautier, Mark Andrew Anderson, Newton Cho, Nicholas David James, Salif Axel Komi, Jimmy James Ravier, Jérôme Gandar, Andreas Rowald, Kay Alexander Bartholdi, Charlotte Marie Jacques Moerman, Achilleas Laskaratos, Laura Ann McCracken, Loïs Thomas Romain Mahe, Arnaud Bichat

Spinal cord injury (SCI) induces haemodynamic instability that threatens survival(1-3), impairs neurological recovery(4,5), increases the risk of cardiovascular disease(6,7), and reduces quality of life(8,9). Haemodynamic instability in this context is due ...

NATURE RESEARCH2021

Recovery of walking after paralysis by regenerating characterized neurons to their natural target region

Grégoire Courtine, Bernard Schneider, Jocelyne Bloch, Quentin Barraud, Jordan Squair, Claudia Kathe, Matthieu Pierre Gautier, Katia Galan, Mark Andrew Anderson, Newton Cho, Nicholas David James, Thomas Haynes Hutson, Laetitia Danielle Philippine Baud, Michael Alexander Skinnider, Achilleas Laskaratos, Marco Milano, Steven Lee Ceto, Anna Lasne

Axon regeneration can be induced across anatomically complete spinal cord injury (SCI), but robust functional restoration has been elusive. Whether restoring neurological functions requires directed regeneration of axons from specific neuronal subpopulatio ...

American Association for the Advancement of Science2023

Wireless closed-loop optogenetics across the entire dorsoventral spinal cord in mice

Stéphanie Lacour, Grégoire Courtine, Quentin Barraud, Ileana Ozana Jelescu, Léonie Asboth, Ivan Furfaro, Claudia Kathe, Kyungjin Kim, Frédéric Pierre Gérald Michoud, Valentina Marie Paggi, Thomas Haynes Hutson, Jimmy James Ravier, Jérôme Gandar, Andreas Rowald, Noaf Salah Ali Alwahab

Optoelectronic systems can exert precise control over targeted neurons and pathways throughout the brain in untethered animals, but similar technologies for the spinal cord are not well established. In the present study, we describe a system for ultrafast, ...

NATURE PORTFOLIO2022

Hypothalamic deep brain stimulation augments walking after spinal cord injury

Nadia Bérard, Michael Hodara, Kristina Sveistyte, Anna Leonhartsberger, Grégoire Courtine, Jocelyne Bloch, Quentin Barraud, Léonie Asboth, Robin Jonathan Demesmaeker, Claudia Kathe, Matthieu Pierre Gautier, Katia Galan, Mark Andrew Anderson, Newton Cho, Nicholas David James, Thomas Haynes Hutson, Jimmy James Ravier, Laetitia Danielle Philippine Baud, Kay Alexander Bartholdi, Achilleas Laskaratos, Camille Claire Varescon, Nicolas Hankov, Inssia Dewany, Nadine Intering, Viviana Aureli, Frédéric Norbert Merlos

A spinal cord injury (SCI) disrupts the neuronal projections from the brain to the region of the spinal cord that produces walking, leading to various degrees of paralysis. Here, we aimed to identify brain regions that steer the recovery of walking after i ...

NATURE PORTFOLIO2024

Activity-dependent spinal cord neuromodulation rapidly restores trunk and leg motor functions after complete paralysis

Dimitri Nestor Alice Van De Ville, Silvestro Micera, Grégoire Courtine, Marco Capogrosso, Jocelyne Bloch, Quentin Barraud, Nawal Noëlle Kinany, Léonie Asboth, Fabien Bertrand Paul Wagner, Robin Jonathan Demesmaeker, Salif Axel Komi, Jimmy James Ravier, Henri Charles Alexandre Lorach, Andreas Rowald, Miroslav Caban, Nathan Antoine Greiner, Carmina Andrea Galvez Solano, Sergio Daniel Hernandez, Laura Ann McCracken, Edeny Baaklini

Epidural electrical stimulation (EES) targeting the dorsal roots of lumbosacral segments restores walking in people with spinal cord injury (SCI). However, EES is delivered with multielectrode paddle leads that were originally designed to target the dorsal ...

NATURE PORTFOLIO2022

Undirected compensatory plasticity contributes to neuronal dysfunction after severe spinal cord injury

Grégoire Courtine, Pavel Musienko, Quentin Barraud, Lucia Florinda Friedli Wittler, Janine Beauparlant

Severe spinal cord injury in humans leads to a progressive neuronal dysfunction in the chronic stage of the injury. This dysfunction is characterized by premature exhaustion of muscle activity during assisted locomotion, which is associated with the emerge ...

Oxford University Press2013

Elezanumab, a human anti-RGMa monoclonal antibody, promotes neuroprotection, neuroplasticity, and neurorecovery following a thoracic hemicompression spinal cord injury in non-human primates

Grégoire Courtine, Quentin Barraud

Spinal cord injury (SCI) is a devastating condition characterized by loss of function, secondary to damaged spinal neurons, disrupted axonal connections, and myelin loss. Spontaneous recovery is limited, and there are no approved pharmaceutical treatments ...

2021

Spatiotemporal neuromodulation therapies engaging muscle synergies improve motor control after spinal cord injury

Silvestro Micera, Stéphanie Lacour, Grégoire Courtine, Jocelyne Bloch, Marco Capogrosso, Quentin Barraud, Eduardo Martin Moraud, Ivan Rusev Minev, Léonie Asboth, Jérôme Gandar, Nikolaus Wenger, Arthur Edouard Hirsch, Pavel Musienko, Laetitia Danielle Philippine Baud, Natalia Pavlova, Julie Kreider

Electrical neuromodulation of lumbar segments improves motor control after spinal cord injury in animal models and humans. However, the physiological principles underlying the effect of this intervention remain poorly understood, which has limited the ther ...

Nature Publishing Group2016

The neurons that restore walking after paralysis

Ruijia Wang, Stéphanie Lacour, Grégoire Courtine, Jocelyne Bloch, Quentin Barraud, Jordan Squair, Léonie Asboth, Fabien Bertrand Paul Wagner, Robin Jonathan Demesmaeker, Claudia Kathe, Matthieu Pierre Gautier, Kyungjin Kim, Katia Galan, Newton Cho, Nicholas David James, Thomas Haynes Hutson, Salif Axel Komi, Laetitia Danielle Philippine Baud, Andreas Rowald, Steven Lee Ceto, Nicola Aldo Regazzi

A spinal cord injury interrupts pathways from the brain and brainstem that project to the lumbar spinal cord, leading to paralysis. Here we show that spatiotemporal epidural electrical stimulation (EES) of the lumbar spinal cord(1-3) applied during neurore ...

NATURE PORTFOLIO2022

Biomaterials. Electronic dura mater for long-term multimodal neural interfaces

Silvestro Micera, Stéphanie Lacour, Grégoire Courtine, Marco Capogrosso, Nicolas Vachicouras, Quentin Barraud, Eduardo Martin Moraud, Ivan Rusev Minev, Léonie Asboth, Tomislav Milekovic, Nikolaus Wenger, Arthur Edouard Hirsch, Pavel Musienko, Jérôme Gandar, Natalia Pavlova

The mechanical mismatch between soft neural tissues and stiff neural implants hinders the long-term performance of implantable neuroprostheses. Here, we designed and fabricated soft neural implants with the shape and elasticity of dura mater, the protectiv ...

American Association for the Advancement of Science2015

Long-term usability and bio-integration of polyimide-based intraneural stimulating electrodes

Silvestro Micera, Grégoire Courtine, Marco Capogrosso, Stanisa Raspopovic, Alessandra Piersigilli, Quentin Barraud, Nawal Noëlle Kinany, Jacopo Rigosa, Sophie Marie Marthe Wurth, Jérôme Gandar, Natalia Pavlova

Stimulation of peripheral nerves has transiently restored lost sensation and has the potential to alleviate motor deficits. However, incomplete characterization of the long-term usability and bio-integration of intra-neural implants has restricted their us ...

Elsevier Sci Ltd2017

Cbp-dependent histone acetylation mediates axon regeneration induced by environmental enrichment in rodent spinal cord injury models

Grégoire Courtine, Quentin Barraud, Claudia Kathe, Thomas Haynes Hutson, Kay Alexander Bartholdi

After a spinal cord injury, axons fail to regenerate in the adult mammalian central nervous system, leading to permanent deficits in sensory and motor functions. Increasing neuronal activity after an injury using electrical stimulation or rehabilitation ca ...

AMER ASSOC ADVANCEMENT SCIENCE2019

Cortico–reticulo–spinal circuit reorganization enables functional recovery after severe spinal cord contusion

Grégoire Courtine, Bernard Schneider, Quentin Barraud, Léonie Asboth, Mark Andrew Anderson, Lucia Florinda Friedli Wittler, Laetitia Danielle Philippine Baud, Janine Beauparlant, Galyna Pidpruzhnykova, Selin Anil, Julie Kreider, Elodie Rey

Severe spinal cord contusions interrupt nearly all brain projections to lumbar circuits producing leg movement. Failure of these projections to reorganize leads to permanent paralysis. Here we modeled these injuries in rodents. A severe contusion abolished ...

2018

Epidural electrical stimulation of the cervical dorsal roots restores voluntary upper limb control in paralyzed monkeys

Stéphanie Lacour, Grégoire Courtine, Jocelyne Bloch, Giuseppe Schiavone, Florian Dylan Fallegger, Quentin Barraud, Tomislav Milekovic, Katia Galan, Nicholas David James

Regaining arm control is a top priority for people with paralysis. Unfortunately, the complexity of the neural mechanisms underlying arm control has limited the effectiveness of neurotechnology approaches. Here, we exploited the neural function of survivin ...

NATURE PORTFOLIO2022

Soft Printable Electrode Coating for Neural Interfaces

Stéphanie Lacour, Grégoire Courtine, Elvira Pirondini, Florian Dylan Fallegger, Quentin Barraud, Arnaud Bichat, Michael Shur

The mechanical mismatch between implantable interfaces and neural tissues may be reduced by employing soft polymeric materials. Here, we report on a simple strategy to prepare and pattern a soft electrode coating of neural interfacing devices based on a sc ...

2020

Cell type prioritization in single-cell data

Grégoire Courtine, Gioele La Manno, Quentin Barraud, Jordan Squair, Claudia Kathe, Matthieu Pierre Gautier, Mark Andrew Anderson, Thomas Haynes Hutson, Michael Alexander Skinnider, Marco Milano

The cell types affected by biological perturbations in complex tissues are uncovered by single-cell analysis. ...

NATURE PUBLISHING GROUP2021

A brain-spine interface alleviating gait deficits after spinal cord injury in primates

Silvestro Micera, Grégoire Courtine, Jocelyne Bloch, Marco Capogrosso, Quentin Barraud, Eduardo Martin Moraud, Fabien Bertrand Paul Wagner, Jérôme Gandar, Jean-Baptiste Mignardot, Tomislav Milekovic, David Allenson Borton, Elodie Rey

Spinal cord injury disrupts the communication between the brain and the spinal circuits that orchestrate movement. To bypass the lesion, brain-computer interfaces(1-3) have directly linked cortical activity to electrical stimulation of muscles, and have th ...

Nature Publishing Group2016