Publications by Riccardo Sinisi

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Novel, clinically relevant, approaches to shift energy balance are urgently needed to combat metabolic disorders such as obesity and diabetes. One promising approach has been the expansion of brown adipose tissues that express uncoupling protein (UCP) 1 an ...

Purpose: Most effective antitumor therapies induce tumor cell death. Non-invasive, rapid and accurate quantitative imaging of cell death is essential for monitoring early response to antitumor therapies. To facilitate this, we previously developed a biocom ...

Recently we showed that a number of carboxylated near-infrared fluorescent (NIRF) cyanine dyes possess strong necrosis avid properties in vitro as well as in different mouse models of spontaneous and therapy-induced tumor necrosis, indicating their potenti ...

Mitochondrial membrane potential (Delta Psi(m)) is a universal selective indicator of mitochondrial function and is known to play a central role in many human pathologies, such as diabetes mellitus, cancer and Alzheimer's and Parkinson's diseases. Here, we ...

Glucose is a major source of energy for most living organisms, and its aberrant uptake is linked to many pathological conditions. However, our understanding of disease-associated glucose flux is limited owing to the lack of robust tools. To date, positron- ...

The invention relates to a technique to detect small molecules using Bioluminescence imaging (BLI) to image and quantify non-invasively, in vitro and in vivo,intracellular metabolite fluxes and which can be applied to azido-modified compounds, such as azid ...

The application provides fluorescent dyes, which are cyanine dyes that incorporate additional aza moieties in the indolenium heterocycles and/or in the methine chains connecting them. Symmetrical and unsymmetrical chemically reactive azacyanine dyes are de ...

We present a single-photon camera for fluorescence imaging capable of providing both intensity and images, with an accuracy better than 100ps; the camera was fabricated in standard CMOS technology. As a first step towards the study of biologically relevant ...

Riccardo Sinisi

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Matrix-Assisted Transplantation of Functional Beige Adipose Tissue

The Necrosis-Avid Small Molecule HQ4-DTPA as a Multimodal Imaging Agent for Monitoring Radiation Therapy-Induced Tumor Cell Death

Pre-clinical Evaluation of a Cyanine-Based SPECT Probe for Multimodal Tumor Necrosis Imaging

A bioluminescent probe for longitudinal monitoring of mitochondrial membrane potential

Bioluminescent-based imaging and quantification of glucose uptake in vivo

Bioluminescence imaging of small biomolecules

Azacyanine dyes and use thereof

Azacyanine dyes and use thereof

Compact imaging system with single-photon sensitivity and picosecond time resolution for fluorescence-guided surgery with lifetime imaging capability

Azacyanine dyes and use thereof