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Traction forces are generated by cellular actin-myosin system and transmitted to the environment through adhesions. They are believed to drive cell motion, shape changes, and extracellular matrix remodeling [1 -3] . However, most of the traction force anal ...

Cell migration is a fundamental property of all animal cells which is involved in processes such as embryogenesis, immune response, tissue regeneration and cancer metastasis. Directional migration requires cell polarization which could happen in response t ...

Plasma membrane tension and the pressure generated by actin polymerization are two antagonistic forces believed to define the protrusion rate at the leading edge of migrating cells [1-5]. Quantitatively, resistance to actin protrusion is a product of membr ...

How cells break symmetry and organize activity at their edges to move directionally is a fundamental question in cell biology. Physical models of cell motility commonly incorporate gradients of regulatory proteins and/or feedback from the motion itself to ...

Alicia Carine Bornert

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Traction Forces Control Cell-Edge Dynamics and Mediate Distance Sensitivity during Cell Polarization

Protrusion-retraction switches and traction forces in spontaneous cell polarization

Contact Angle at the Leading Edge Controls Cell Protrusion Rate

Minimal model for spontaneous cell polarization and edge activity in oscillating, rotating and migrating cells