Laetitia Marie Mélanie Souillart

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Selective cleavages of carbon-carbon bonds catalyzed by transition-metal complexes have been shown to be increasingly versatile tools for organic synthesis allowing for complementary synthetic strategies. Numerous examples of transition-metal catalyzed C-C ...

The exploitation of strain release in small rings as driving force to enable complex transformations is a powerful synthetic tool. Among them, cyclobutanones are particularly versatile substrates that can be elaborated in a wide variety of structurally div ...

The activation of carbon-carbon bonds has attracted much attention in the past decade. Despite important progress, the development of asymmetric reactions lags behind. For the first time, asymmetric rhodium(I)-catalyzed direct oxidative additions into enan ...

The selective functionalization of carbon-carbon sigma bonds is a synthetic strategy that offers uncommon retrosynthetic disconnections. Despite progress in CC activation and its great importance, the development of asymmetric reactions lags behind. Rhodiu ...

The lactone motif is ubiquitous in natural products and pharmaceuticals. The Tishchenko disproportionation of two aldehydes, a carbonyl hydroacylation, is an efficient and atom-economic access to lactones. However, these reaction types are limited to the t ...

The catalytic activation of carbon-carbon single bonds is a major challenge in organometallic chemistry, since the lack of prefunctionalization steps opens the way to new, economically and ecologically attractive reaction pathways. Strained ring substrates ...

Rhodium(I)-catalyzed beta-carbon eliminations of tert-cyclobutanols followed by oxidative addition give benzorhoda(III)cyclopentenes. These key intermediates trigger intramolecular C-H arylations leading to beta-tetralones with quaternary stereogenic cente ...

Laetitia Marie Mélanie Souillart

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Catalytic C-C Bond Activations via Oxidative Addition to Transition Metals

Regiodivergent Cyclobutanone Cleavage: Switching Selectivity with Different Lewis Acids

Enantioselective Rhodium-catalyzed C-C Bond Activation of Cyclobutanones

Highly Enantioselective Rhodium(I)-Catalyzed Activation of Enantiotopic Cyclobutanone C-C Bonds

Highly Enantioselective Rhodium(I)-Catalyzed Carbonyl Carboacylations Initiated by C-C Bond Activation

Strain-Promoted C-C Bond Cleavages of Cyclobutanes : A Molecular Complexity Generating Tool

Exploitation of Rh(I)-Rh(III) cycles in enantioselective C-C bond cleavages: access to beta-tetralones and benzobicyclo[2.2.2]octanones