Paulo Henrique Jacob Silva

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Increasing resistance to antiviral drugs approved for the treatment of influenza urges the development of novel compounds. Ideally, this should be complemented by a careful consideration of the administration route. 6′siallyllactosamine-functionalized β-cy ...

In recent decades, epidemics and pandemics have multiplied throughout the world, with viruses generally being the primary responsible agents. Among these, influenza viruses play a key role, as they potentially cause severe respiratory distress, representin ...

Dispersion of objects in a fluid phase can be classified as solutions (Gibbs free energy of mixing, Delta G(mix) < 0) or suspensions (Delta G(mix) > 0) depending on their thermodynamic stability. Small objects tend to form solutions, larger ones suspension ...

The deposition of amyloid-beta (A beta) plaques in the brain is a significant pathological signature of Alzheimer's disease, correlating with synaptic dysfunction and neurodegeneration. Several compounds, peptides, or drugs have been designed to redirect o ...

Membrane fusion is essential for the basal functionality of eukaryotic cells. In physiological conditions, fusion events are regulated by a wide range of specialized proteins, operating with finely tuned local lipid composition and ionic environment. Fusog ...

The herpes simplex virus (HSV) is associated with serious conditions, such as encephalitis and blindness, and its infection is closely linked to significant vascular complications and coagulation issues, particularly in individuals with compromised immune ...

Viral infections caused by bacteriophages, i.e., viruses that kill bacteria are one of the most dangerous and common threats for bacteria-based bioreactors. More than 70% of biotechnology companies have admitted to encountering this problem. Despite phage ...

The arrangement of nanoscale building blocks into patternswithmicroscale periodicity is challenging to achieve via self-assemblyprocesses. Here, we report on the phase-transition-driven collectiveassembly of gold nanoparticles in a thermotropic liquid crys ...

Influenza viruses are a leading cause of morbidity and mortality worldwide. These air-borne pathogens are able to cross the species barrier, leading to regular seasonal epidemics and sporadic pandemics. Influenza viruses also possess a high genetic variabi ...

Increasing evidence suggests that amyloid polymorphism gives rise to different strains of amyloids with distinct toxicities and pathology-spreading properties. Validating this hypothesis is challenging due to a lack of tools and methods that allow for the ...

Surface modification of ligand protected nanoparticles (NPs) can be driven by ligand exchange reactions (LER). Little is known about the mechanism of this reaction, especially when the particles are not spherical. Here, we use the intrinsic hot spots gener ...

This thesis presents a systematic study of how different types monolayer-protected AuNPs interact with amyloid fibers. We report a class of amphiphilic gold nanoparticles capable of adsorbing onto specific surface features on these types of protein fibers. ...

Respiratory viruses including the respiratory syncytial virus (RSV) aggravate the global burden of virus-inflicted morbidity and mortality. Entry inhibitors are a promising class of antiviral drugs for combating these viruses, as they can prevent infection ...

Influenza is one of the most widespread viral infections worldwide and represents a major public health problem. The risk that one of the next pandemics is caused by an influenza strain is high. It is important to develop broad-spectrum influenza antiviral ...

Here we present a method to extract thermodynamic quantities for nanoparticle dispersions in solvents. The method is based on the study of tomograms obtained from cryogenic electron tomography (cryoET). The approach is demonstrated for gold nanoparticles ( ...

Most viruses start their invasion by binding to glycoproteins' moieties on the cell surface (heparan sulfate proteoglycans [HSPG] or sialic acid [SA]). Antivirals mimicking these moieties multivalently are known as broad-spectrum multivalent entry inhibito ...

One of the biggest threats for bacteria-based bioreactors in the biotechnology industry is infections caused by bacterial viruses called bacteriophages. More than 70% of companies admitted to encountering this problem. Despite phage infections being such a ...

Diagnosis and treatment of brain disorders, such as epilepsy, neurodegenerative diseases and tumors, would benefit from innovative approaches to deliver therapeutic or diagnostic compounds into the brain parenchyma, with either a homogeneous or a targeted ...

Paulo Henrique Jacob Silva

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Inhibition of influenza virus infection in mice by pulmonary administration of a spray dried antiviral drug

Development of Broad-Spectrum β-Cyclodextrins-Based Nanomaterials Against Influenza Viruses

Experimental Method to Distinguish between a Solution and a Suspension

The Clustering of mApoE Anti-Amyloidogenic Peptide on Nanoparticle Surface Does Not Alter Its Performance in Controlling Beta-Amyloid Aggregation

Cholesterol-Containing Liposomes Decorated With Au Nanoparticles as Minimal Tunable Fusion Machinery

Structure-Activity Relationship Studies of Glycosaminoglycan Mimetic Macrocycles Against Herpes

Broad-spectrum nanoparticles against bacteriophage infections

Reversible Microscale Assembly of Nanoparticles Driven by the Phase Transition of a Thermotropic Liquid Crystal

Interferon Lambda Delays the Emergence of Influenza Virus Resistance to Oseltamivir

Unraveling the complexity of amyloid polymorphism using gold nanoparticles and cryo-EM

Site-selective surface enhanced Raman scattering study of ligand exchange reactions on aggregated Ag nanocubes

Discriminative adsorption of amphiphilic monolayer protected gold nanoparticles on amyloid fibers

Development of an inhalable antiviral powder formulation against respiratory syncytial virus

Non-Toxic Virucidal Macromolecules Show High Efficacy Against Influenza Virus Ex Vivo and In Vivo

Cryogenic electron tomography to determine thermodynamic quantities for nanoparticle dispersions

Benzene with Alkyl Chains Is a Universal Scaffold for Multivalent Virucidal Antivirals

Peptide-Grafted Nontoxic Cyclodextrins and Nanoparticles against Bacteriophage Infections

Distribution of superparamagnetic Au/Fe nanoparticles in an isolated guinea pig brain with an intact blood brain barrier

Amphiphilic Au nanoparticles and cholesterol-containing liposomes serving as minimal tunable fusion machinery