Dongryeol Ryu

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Related publications (27)

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LRH-1-dependent programming of mitochondrial glutamine processing drives liver cancer

Arnaud Comment, Kristina Schoonjans, Johan Auwerx, Norman Lionel Moullan, Dongryeol Ryu, Maaike Hélène Oosterveer, Emine Can, Pan Xu, Xu Wang, Hadrien Charles Edouard Demagny

Various tumors develop addiction to glutamine to support uncontrolled cell proliferation. Here we identify the nuclear receptor liver receptor homolog 1 (LRH-1) as a key regulator in the process of hepatic tumorigenesis through the coordination of a noncan ...

Cold Spring Harbor Laboratory2016

De novo NAD(+) synthesis enhances mitochondrial function and improves health

Elena Katsyuba, Kristina Schoonjans, Johan Auwerx, Dongryeol Ryu, Adrienne Joëlle Laurence Mottis, Karim Laurent Gariani, Olli Juhani Matilainen, Marika Olga Zietak

Nicotinamide adenine dinucleotide (NAD(+)) is a co-substrate for several enzymes, including the sirtuin family of NAD(+)-dependent protein deacylases. Beneficial effects of increased NAD(+) levels and sirtuin activation on mitochondrial homeostasis, organi ...

NATURE PUBLISHING GROUP2018

SIRT7 modulates the stability and activity of the renal K-Cl cotransporter KCC4 through deacetylation

Johan Auwerx, Lilia Noriega Lopez, Dongryeol Ryu

SIRT7 is a NAD(+)-dependent deacetylase that controls important aspects of metabolism, cancer, and bone formation. However, the molecular targets and functions of SIRT7 in the kidney are currently unknown. In silico analysis of kidney transcripts of the BX ...

2021

A SIRT7-Dependent Acetylation Switch of GABPβ1 Controls Mitochondrial Function

Kristina Schoonjans, Johan Auwerx, Dongryeol Ryu, Giuseppe Lo Sasso, Hongbo Zhang, Alessia Perino

Mitochondrial activity is controlled by proteins encoded by both nuclear and mitochondrial DNA. Here, we identify Sirt7 as a crucial regulator of mitochondrial homeostasis. Sirt7 deficiency in mice induces multisystemic mitochondrial dysfunction, which is ...

Cell Press2014

Agents and methods using thereof for the prevention and treatment of stem cells senescence

Johan Auwerx, Dongryeol Ryu, Hongbo Zhang, Keir Joe Menzies

The present invention relates to agents that prevent or reverse process of stem cell senescence. Further, the invention relates to methods and compositions useful in the prevention and/or treatment of stem senescence. ...

2017

The NAD plus Salvage Pathway Potently Stimulates Hematopoiesis through Increased Mitochondrial Clearance and Asymmetric Division

Matthias Lütolf, Bart Deplancke, Nicola Vannini, Carlos Canto Alvarez, Mukul Girotra, Aurélien Laurent Jean-Charles Oggier, Dongryeol Ryu, Eija Riitta Pirinen, Olaia Maria Naveiras Torres-Quiroga, Pernille Yde Rainer, Gennady Nikitin, Vasco Ledebur de Antas de Campos, Joanna Ratajczak, Josefine Catharina Pedersen Tratwal, George Coukos, Sonja Giger, Shanti Rojas-Sutterlin, Yang Li

AMER SOC HEMATOLOGY2018

Agents and methods using thereof for the prevention and treatment of stem cell muscle disorders

Johan Auwerx, Dongryeol Ryu, Hongbo Zhang, Keir Joe Menzies

Abstract of the invention: The present invention relates to agents that induce mitochondrial unfolded protein response (UPR mt ) in muscle stem cells and prevents or reverse process of muscle stem cell senescence. Further, the invention relates to methods ...

2017