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Florian Dylan Fallegger

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Related publications (26)

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Chronic recording of cortical activit y underlying vocalization in awake minipigs

Stéphanie Lacour, Giuseppe Schiavone, Florian Dylan Fallegger

Background: Investigating brain dynamics underlying vocal production in animals is a powerf u l w a y to inform on the neural bases of human speech. In particular, brain networks underlying vocal production in non-human primates show striking similarities ...

ELSEVIER2022

Neuroprosthetic baroreflex controls haemodynamics after spinal cord injury

Stéphanie Lacour, Grégoire Courtine, Marco Capogrosso, Jocelyne Bloch, Giuseppe Schiavone, Florian Dylan Fallegger, Nicolas Vachicouras, Quentin Barraud, Jordan Squair, Ileana Ozana Jelescu, Eduardo Martin Moraud, Fabien Bertrand Paul Wagner, Robin Jonathan Demesmaeker, Claudia Kathe, Matthieu Pierre Gautier, Mark Andrew Anderson, Newton Cho, Nicholas David James, Salif Axel Komi, Jimmy James Ravier, Jérôme Gandar, Andreas Rowald, Kay Alexander Bartholdi, Charlotte Marie Jacques Moerman, Achilleas Laskaratos, Laura Ann McCracken, Loïs Thomas Romain Mahe, Arnaud Bichat

Spinal cord injury (SCI) induces haemodynamic instability that threatens survival(1-3), impairs neurological recovery(4,5), increases the risk of cardiovascular disease(6,7), and reduces quality of life(8,9). Haemodynamic instability in this context is due ...

NATURE RESEARCH2021

A soft, scalable and adaptable multi-contact cuff electrode for targeted peripheral nerve modulation

Olivier Didier Christian Rizzo, Silvestro Micera, Stéphanie Lacour, Florian Dylan Fallegger, Ivan Furfaro, Katia Galan, Valentina Marie Paggi

Background: Cuff electrodes target various nerves throughout the body, providing neuromodulation therapies for motor, sensory, or autonomic disorders. However, when using standard, thick silicone cuffs, fabricated in discrete circular sizes, complications ...

2024

A low-profile electromechanical packaging system for soft-to-flexible bioelectronic interfaces

Stéphanie Lacour, Giuseppe Schiavone, Florian Dylan Fallegger, Alix Esther Anne Trouillet, Florent-Valéry Coen

Interfacing the human body with the next generation of electronics requires technological advancement in designing and producing bioelectronic circuits. These circuits must integrate electrical functionality while simultaneously addressing limitations in m ...

2023

Conformable Hybrid Systems for Implantable Bioelectronic Interfaces

Stéphanie Lacour, Giuseppe Schiavone, Florian Dylan Fallegger

Conformable bioelectronic systems are promising tools that may aid the understanding of diseases, alleviate pathological symptoms such as chronic pain, heart arrhythmia, and dysfunctions, and assist in reversing conditions such as deafness, blindness, and ...

Wiley2020

Microstructured thin-film electrode technology enables proof of concept of scalable, soft auditory brainstem implants

Stéphanie Lacour, Florian Dylan Fallegger, Nicolas Vachicouras, Valentina Marie Paggi, Christina Myra Tringides, Jennifer Mary Adrienne Alice Macron

Auditory brainstem implants (ABIs) provide sound awareness to deaf individuals who are not candidates for the cochlear implant. The ABI electrode array rests on the surface of the cochlear nucleus (CN) in the brainstem and delivers multichannel electrical ...

2019

High-resolution prosthetic hearing with a soft auditory brainstem implant in macaques

Stéphanie Lacour, Jocelyne Bloch, Florian Dylan Fallegger, Ivan Furfaro, Alix Esther Anne Trouillet, Florent-Valéry Coen, Emilie Cornelia Maria Revol, Laurine Kolly

Individuals with compromised cochlear nerves are ineligible for cochlear implants and instead rely on auditory brainstem implants (ABIs). Most users of ABIs experience sound awareness, which aids in lip reading, yet not speech intelligibility. Here we engi ...

2025

Soft, Implantable Bioelectronic Interfaces for Translational Research

Evgenia Vladimirova Roussinova, Stéphanie Lacour, Grégoire Courtine, Marco Capogrosso, Jocelyne Bloch, Sébastien Jiguet, Giuseppe Schiavone, Nicolas Vachicouras, Florian Dylan Fallegger, Ivan Furfaro, Xiaoyang Kang, Andreas Rowald, Simon Borgognon, Ismael Seanez Gonzalez

The convergence of materials science, electronics, and biology, namely bioelectronic interfaces, leads novel and precise communication with biological tissue, particularly with the nervous system. However, the translation of lab‐based innovation toward cli ...

Wiley2020

Subdural Soft Electrocorticography (ECoG) Array Implantation and Long-Term Cortical Recording in Minipigs

Stéphanie Lacour, Florian Dylan Fallegger, Alix Esther Anne Trouillet

Neurological impairments and diseases can be diagnosed or treated using electrocorticography (ECoG) arrays. In drug-resistant epilepsy, these help delineate the epileptic region to resect. In long-term applications such as brain-computer interfaces, these ...

JOURNAL OF VISUALIZED EXPERIMENTS2023

Viscoelastic surface electrode arrays to interface with viscoelastic tissues

Stéphanie Lacour, Florian Dylan Fallegger, Nicolas Vachicouras, Alix Esther Anne Trouillet, Christina Myra Tringides

Bioelectronic interfacing with living tissues should match the biomechanical properties of biological materials to reduce damage to the tissues. Here, the authors present a fully viscoelastic microelectrode array composed of an alginate matrix and carbon-b ...

Nature Research2021

A 16-Channel Wireless Neural Recording System-on-Chip with CHT Feature Extraction Processor in 65nm CMOS

Yusuf Leblebici, Volkan Cevher, Stéphanie Lacour, Catherine Dehollain, Florian Dylan Fallegger, Cosimo Aprile, Kerim Türe, Alix Esther Anne Trouillet, Arda Uran

Wireless implantable neural recording chips enable multichannel data acquisition with high spatiotemporal resolution in situ. Recently, the use of machine learning approaches on neural data for diagnosis and prosthesis control have renewed the interest in ...

2021

Epidural electrical stimulation of the cervical dorsal roots restores voluntary upper limb control in paralyzed monkeys

Stéphanie Lacour, Grégoire Courtine, Jocelyne Bloch, Giuseppe Schiavone, Florian Dylan Fallegger, Quentin Barraud, Tomislav Milekovic, Katia Galan, Nicholas David James

Regaining arm control is a top priority for people with paralysis. Unfortunately, the complexity of the neural mechanisms underlying arm control has limited the effectiveness of neurotechnology approaches. Here, we exploited the neural function of survivin ...

NATURE PORTFOLIO2022

Soft Printable Electrode Coating for Neural Interfaces

Stéphanie Lacour, Grégoire Courtine, Elvira Pirondini, Florian Dylan Fallegger, Quentin Barraud, Arnaud Bichat, Michael Shur

The mechanical mismatch between implantable interfaces and neural tissues may be reduced by employing soft polymeric materials. Here, we report on a simple strategy to prepare and pattern a soft electrode coating of neural interfacing devices based on a sc ...

2020

Integration of hybrid material systems in conformable neural interfaces

Florian Dylan Fallegger

Neural interfaces are devices that are implanted into the body and interface electrically with the central (CNS) or peripheral nervous system. They are inserted surgically for short periods of time or chronically to diagnose or treat several neural disease ...

EPFL2020

Recruitment of upper-limb motoneurons with epidural electrical stimulation of the cervical spinal cord

Stéphanie Lacour, Grégoire Courtine, Giuseppe Schiavone, Florian Dylan Fallegger, Nicholas David James, Henri Charles Alexandre Lorach, Simon Borgognon, Nathan Antoine Greiner

Epidural electrical stimulation (EES) of lumbosacral sensorimotor circuits improves leg motor control in animals and humans with spinal cord injury (SCI). Upper-limb motor control involves similar circuits, located in the cervical spinal cord, suggesting t ...

Nature Research2021

Hybrid soft-rigid electrical interconnection system

Stéphanie Lacour, Giuseppe Schiavone, Florian Dylan Fallegger

It is disclosed an electrical interconnection system comprising: i) an interconnection board comprising an intrinsically non elastic substrate, said substrate having a first face and an opposed second face, and at least one conductive track on and/or withi ...

2021

MRI-Compatible and Conformal Electrocorticography Grids for Translational Research

Stéphanie Lacour, Grégoire Courtine, Giuseppe Schiavone, Florian Dylan Fallegger, Fabien Bertrand Paul Wagner, Ludovic Serex

Intraoperative electrocorticography (ECoG) captures neural information from the surface of the cerebral cortex during surgeries such as resections for intractable epilepsy and tumors. Current clinical ECoG grids come in evenly spaced, millimeter-sized elec ...

2021

Long-term functionality of a soft electrode array for epidural spinal cord stimulation in a minipig model

Stéphanie Lacour, Grégoire Courtine, Jocelyne Bloch, Marco Capogrosso, Giuseppe Schiavone, Florian Dylan Fallegger, Nicolas Vachicouras, Fabien Bertrand Paul Wagner, Xiaoyang Kang

Long-term biointegration of man-made neural interfaces is influenced by the mechanical properties of the implant materials. Substantial experimental work currently aims at replacing conventional hard implant materials with soft alternatives that can favour ...

IEEE2018

Deployment of an electrocorticography system with a soft robotic actuator

Stéphanie Lacour, Florian Dylan Fallegger, Kyungjin Kim, Alix Esther Anne Trouillet, Sukho Song

Electrocorticography (ECoG) is a minimally invasive approach frequently used clinically to map epileptogenic regions of the brain and facilitate lesion resection surgery and increasingly explored in brain-machine interface applications. Current devices dis ...

AMER ASSOC ADVANCEMENT SCIENCE2023

A 16-Channel Neural Recording System-on-Chip With CHT Feature Extraction Processor in 65-nm CMOS

Yusuf Leblebici, Volkan Cevher, Stéphanie Lacour, Catherine Dehollain, Florian Dylan Fallegger, Cosimo Aprile, Kerim Türe, Alix Esther Anne Trouillet, Arda Uran, Emilie Cornelia Maria Revol

Next generation invasive neural interfaces require fully implantable wireless systems that can record from a large number of channels simultaneously. However, transferring the recorded data from the implant to an external receiver emerges as a significant ...

2022