Publications by Sina Nassiri | EPFL Graph Search

Related publications (11)

Mesenchymal stromal cell exosomes prevent and revert experimental pulmonary fibrosis through modulation of monocyte phenotypes

Mesenchymal stromal/stem cell (MSC) therapy has shown promise in experimental models of idiopathic pulmonary fibrosis (IPF). The aim of this study was to test the therapeutic effects of extracellular vesicles produced by human BM MSCs (MEx) in a bleomycin- ...

AMER SOC CLINICAL INVESTIGATION INC2019

Overcoming microenvironmental resistance to PD-1 blockade in genetically engineered lung cancer models

Michele De Palma, Etienne Meylan, Nadine Fournier, Chiara Cianciaruso, Sina Nassiri, Amaia Martinez Usatorre, Ece Kadioglu, Ioanna Keklikoglou, Gael Luis Boivin, Alan Nicolas Thierry Guichard, Bruno Torchia

Immune checkpoint blockade (ICB) with PD-1 or PD-L1 antibodies has been approved for the treatment of nonsmall cell lung cancer (NSCLC). However, only a minority of patients respond, and sustained remissions are rare. Both chemotherapy and antiangiogenic d ...

AMER ASSOC ADVANCEMENT SCIENCE2021

Apelin-driven endothelial cell migration sustains intestinal progenitor cells and tumor growth

Michele De Palma, Mauro Delorenzi, Mario Leonardo Squadrito, Nadine Fournier, Sina Nassiri

Stem and progenitor cells residing in the intestinal crypts drive the majority of colorectal cancers (CRCs), yet vascular contribution to this niche remains largely unexplored. Vascular endothelial growth factor A (VEGFA) is a key driver of physiological a ...

Springernature2022

Endothelial Calcineurin Signaling Restrains Metastatic Outgrowth by Regulating Bmp2

Mauro Delorenzi, Nadine Fournier, Sina Nassiri

Calcineurin/NFAT signaling is active in endothelial cells and is proposed to be an essential component of the tumor angiogenic response. Here, we investigated the role of endothelial calcineurin signaling in vivo in physiological and pathological angiogene ...

2019

T cell–induced CSF1 promotes melanoma resistance to PD1 blockade

Michele De Palma, George Coukos, Krisztian Homicsko, Sina Nassiri

Colony-stimulating factor 1 (CSF1) is a key regulator of monocyte/macrophage differentiation that sustains the protumorigenic functions of tumor-associated macrophages (TAMs). We show that CSF1 is expressed in human melanoma, and patients with metastatic m ...

2018

Molecular Profiling and Functional Analysis of Macrophage-Derived Tumor Extracellular Vesicles

Michele De Palma, Romain Hamelin, Chiara Cianciaruso, Sina Nassiri, Bruno Torchia, Tim Beltraminelli, Florent Philippe Maurice Duval

Extracellular vesicles (EVs), including exosomes, modulate multiple aspects of cancer biology. Tumor-associated macrophages (TAMs) secrete EVs, but their molecular features and functions are poorly characterized. Here, we report methodology for the enrichm ...

2019

Macrophage interference on chemotherapy

Michele De Palma, Chiara Cianciaruso, Sina Nassiri

NATURE PUBLISHING GROUP2019

Antiangiogenic immunotherapy suppresses desmoplastic and chemoresistant intestinal tumors in mice

Matthias Lütolf, Michele De Palma, Mauro Delorenzi, Mario Leonardo Squadrito, Sina Nassiri, Nikolche Gjorevski, Alan Nicolas Thierry Guichard

Mutations in APC promote colorectal cancer (CRC) progression through uncontrolled WNT signaling. Patients with desmoplastic CRC have a significantly worse prognosis and do not benefit from chemotherapy, but the mechanisms underlying the differential respon ...

2020

Integrin-Mediated Macrophage Adhesion Promotes Lymphovascular Dissemination in Breast Cancer

Michele De Palma, Mario Leonardo Squadrito, Sina Nassiri

Lymphatic vasculature is crucial for metastasis in triple-negative breast cancer (TNBC); however, cellular and molecular drivers controlling lymphovascular metastasis are poorly understood. We define a macrophage-dependent signaling cascade that facilitate ...

2019

Determinants of tumor resistance to anti-angiogenic immunotherapy in mouse models of Kras-mutant NSCLC

Michele De Palma, Etienne Meylan, Chiara Cianciaruso, Sina Nassiri, Amaia Martinez Usatorre, Ece Kadioglu, Ioanna Keklikoglou, Alan Nicolas Thierry Guichard, Bruno Torchia

AMER ASSOC CANCER RESEARCH2021

Stem cell-like memory CD8 T cells establish early in the acute response to Yellow Fever vaccination

Sina Nassiri

E M H SWISS MEDICAL PUBLISHERS LTD2018