Publications by Francesco Stellacci

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Recovering monomers from the depolymerization of thermosets presents a significant challenge, which becomes even more daunting if one sets the goal of doing it directly, i.e., without complex chemical separation steps. To this end, we have synthesized a ne ...

Increasing evidence suggests that amyloid polymorphism gives rise to different strains of amyloids with distinct toxicities and pathology-spreading properties. Validating this hypothesis is challenging due to a lack of tools and methods that allow for the ...

Nanoparticles (NPs) have sizes that approach those of pathogens and they can interact with the membranes of eukaryotic cells in an analogous fashion. Typically, NPs are taken up by the cell via the plasma membrane by receptor-mediated processes and subsequ ...

Surface modification of ligand protected nanoparticles (NPs) can be driven by ligand exchange reactions (LER). Little is known about the mechanism of this reaction, especially when the particles are not spherical. Here, we use the intrinsic hot spots gener ...

Food engineering faces the difficult challenge of combining taste, i.e., tailoring texture and rheology of food matrices with the balanced intake of healthy nutrients. In materials science, fiber suspensions and composites have been developed as a versatil ...

Protein-protein interactions (PPIs) differ when measured in test tubes and cells due to the complexity of the intracellular environment. Free amino acids (AAs) and their derivatives constitute a significant fraction of the intracellular volume and mass. Re ...

The development of mechanically robust, chemically stable, and yet recyclable polymers represents an essential undertaking in the context of advancing a circular economy for plastics. Here, we introduce a novel cleavable β-(1,3-dioxane)ester (DXE) linkage, ...

Lipid membrane fusion is an essential process for a number of critical biological functions. The overall process is thermodynamically favorable but faces multiple kinetic barriers along the way. Inspired by nature's engineered proteins such as SNAP recepto ...

Transmission of viruses through contact with contaminated surfaces is an important pathway for the spread of infections. Antiviral surface coatings are useful to minimize such risks. Current state-of-the-art approaches toward antiviral surface coatings eit ...

Gold nanoparticles covered with a mixture of 1-octanethiol (OT) and 11-mercapto-1-undecane sulfonic acid (MUS) have been extensively studied because of their interactions with cell membranes, lipid bilayers, and viruses. The hydrophilic ligands make these ...

Intensely and broadly absorbing nanoparticles (IBANs) of silver protected by arylthiolates were recently synthesized and showed unique optical properties, yet question of their dispersity and their molecular formulas remained. Here IBANs are identified as ...

The critical micelle concentration (CMC) is the key characterization of surfactants. To date, no method can yield sequential CMC measurements in an automated fashion. This work introduces SIMO (smart integrator for manual operations), a novel robotic platf ...

Respiratory viruses including the respiratory syncytial virus (RSV) aggravate the global burden of virus-inflicted morbidity and mortality. Entry inhibitors are a promising class of antiviral drugs for combating these viruses, as they can prevent infection ...

Amphiphilic gold nanoparticles with diameters in the 2-4 nm range are promising as theranostic agents thanks to their spontaneous translocation through cell membranes. This study addresses the effects that these nanoparticles may have on a distinct feature ...

Influenza is one of the most widespread viral infections worldwide and represents a major public health problem. The risk that one of the next pandemics is caused by an influenza strain is high. It is important to develop broad-spectrum influenza antiviral ...

Here we present a method to extract thermodynamic quantities for nanoparticle dispersions in solvents. The method is based on the study of tomograms obtained from cryogenic electron tomography (cryoET). The approach is demonstrated for gold nanoparticles ( ...

Bimetallic particles based on gold and iron have been gathering increasing interest in biomedical applications because of the synergic combination of the plasmonic features of the inert gold component with the magnetic properties of the iron or iron oxide ...

Most viruses start their invasion by binding to glycoproteins' moieties on the cell surface (heparan sulfate proteoglycans [HSPG] or sialic acid [SA]). Antivirals mimicking these moieties multivalently are known as broad-spectrum multivalent entry inhibito ...

The design and the characterization of functionalized gold nanoparticles supracrystals require atomically resolved information on both the metallic core and the external organic ligand shell. At present, there is no known approach to characterize simultane ...

It is accepted that the ligand shell morphology of nanoparticles coated with a monolayer of molecules can be partly responsible for important properties such as cell membrane penetration and wetting. When binary mixtures of molecules coat a nanoparticle, t ...

Francesco Stellacci

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Direct Monomer Recovery from Ring-Closing Depolymerization of Thermosets

Unraveling the complexity of amyloid polymorphism using gold nanoparticles and cryo-EM

An Atomistic Look into Bio-inspired Nanoparticles and their Molecular Interactions with Cells

Site-selective surface enhanced Raman scattering study of ligand exchange reactions on aggregated Ag nanocubes

Microstructured Fibers for the Production of Food

Amino Acids and Their Biological Derivatives Modulate Protein-Protein Interactions in an Additive Way

Reaction of β-Ketoester and 1,3-Diol to Access Chemically Recyclable and Mechanically Robust Poly(vinyl alcohol) Thermosets through Incorporation of β-(1,3-dioxane)ester

Calcium-triggered fusion of lipid membranes is enabled by amphiphilic nanoparticles

Lignin: A Sustainable Antiviral Coating Material

Synthesis and Characterization of Amphiphilic Gold Nanoparticles

Ag-44(SR)(30)(4-): a silver-thiolate superatom complex

Robot-Assisted Measurement of the Critical Micelle Concentration

Development of an inhalable antiviral powder formulation against respiratory syncytial virus

Amphiphilic gold nanoparticles perturb phase separation in multidomain lipid membranes

Non-Toxic Virucidal Macromolecules Show High Efficacy Against Influenza Virus Ex Vivo and In Vivo

Cryogenic electron tomography to determine thermodynamic quantities for nanoparticle dispersions

Recent Advances in the Synthesis and Applications of Multimodal Gold-Iron Nanoparticles

Benzene with Alkyl Chains Is a Universal Scaffold for Multivalent Virucidal Antivirals

Order/Disorder Dynamics in a Dodecanethiol-Capped Gold Nanoparticles Supracrystal by Small-Angle Ultrafast Electron Diffraction

Determination of monolayer-protected gold nanoparticle ligand-shell morphology using NMR