Albert Santamaria Martinez

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Simple Summary Breast cancer stem cells are a subset of transformed cells that sustain tumor growth and can metastasize to secondary organs. Since metastasis accounts for most cancer deaths, it is of paramount importance to understand the cellular and mole ...

The efficacy of anti-cancer therapies depends on the genomic composition of the tumor, its microenvironment, spatial organization, and intra-tumor heterogeneity. B-cell lymphomas are a heterogeneous group of tumors emerging from B-cells at different stages ...

Breast cancer metastasis is a complex process that depends not only on intrinsic characteristics of metastatic stem cells, but also on the particular microenvironment that supports their growth and modulates the plasticity of the system. In search for micr ...

Cysteine cathepsins are a family of proteases that are relevant therapeutic targets for the treatment of different cancers and other diseases. However, no clinically approved drugs for these proteins exist, as their systemic inhibition can induce deleterio ...

Albert Santamaria Martinez

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The Tumor Microenvironment as a Driving Force of Breast Cancer Stem Cell Plasticity

Development of patient-derived lymphomoids with preserved tumor architecture for lymphoma therapy screening

TGFBI modulates tumour hypoxia and promotes breast cancer metastasis

Antibody-peptide conjugates deliver covalent inhibitors blocking oncogenic cathepsins