Publications by Yuya Okawa | EPFL Graph Search

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Stem cell self-renewal, commitment and reprogramming rely on a poorly understood coordination of cell cycle progression and execution of cell fate choices. Using existing experimental paradigms, it has not been possible to probe this relationship systemati ...

The behaviour of mammalian cells in a tissue is governed by the three-dimensional (3D) microenvironment and involves a dynamic interplay between biochemical and mechanical signals provided by the extracellular matrix (ECM), cell–cell interactions and solub ...

Since the discovery of induced pluripotent stem cells (iPSCs), numerous approaches have been explored to improve the original protocol, which is based on a two-dimensional (2D) cell-culture system. Surprisingly, nothing is known about the effect of a more ...

Yuya Okawa

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Predicting stem cell fate changes by differential cell cycle progression patterns

3D niche microarrays for systems-level analyses of cell fate

Defined three-dimensional microenvironments boost induction of pluripotency

Direct Somatic Cell Reprogramming in Synthetic 3D Microenvironments