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Liang Qiao

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Related publications (47)

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Plate for matrix-assisted laser desorption ionization mass spectrometry for, e.g. analyzing peptide, has substrate that is covered with light sensitive matrix with light absorber, charge carrier, probe molecule and photo-sensitizer

Hubert Girault, Liang Qiao, Christophe Roussel, Niels Erik Lion

NOVELTY - The plate has electrically conductive substrate (1) that is covered with light sensitive matrix (2). The matrix comprises light absorber, charge carrier, probe molecule and photo-sensitizer (3) arranged to oxidize probe molecule by irradiation of ...

2008

Electrochemically Controlled Proton-Transfer-Catalyzed Reactions at Liquid-Liquid Interfaces: Nucleophilic Substitution on Ferrocene Methanol

Hubert Girault, Pekka Eero Peljo, Liang Qiao

The generation of α-ferrocenyl carbocations from ferrocenyl alcohols for SN1 substitution at the water–organic solvent interface is initiated by the transfer of protons into the organic phase. The proton flux, and hence the reaction rate, can be controlled ...

Wiley-Blackwell2013

An Efficient Drug Metabolism Strategy Based on Microsome-Mesoporous Organosilica Nanoreactors

Hubert Girault, Liang Qiao

A rapid and accurate in-vitro drug metabolism strategy has been proposed based on the design of a biomimetic nanoreactor composed of amino-functionalized periodic mesoporous organosilica (NH2-PMO) and microsomes. The amphiphilic and positive charged NH2-PM ...

Amer Chemical Soc2014

Proteins/peptides purification by a three-well OFFGEL electrophoresis with immobilized ultra narrow pH gradient gels

Hubert Girault, Liang Qiao, Fernando Cortes Salazar, Elena Tobolkina

Purification and desalting of protein and peptide samples by a three-well OFFGEL electrophoresis with immobilized ultra narrow pH gradient gels is proposed as a fast preparative strategy for proteomics. The gist of this strategy is to separate the proteins ...

Royal Society of Chemistry2014

Amino-functionalized macroporous silica for efficient tryptic digestion in acidic solutions

Hubert Girault, Liang Qiao

Amino-functionalized macroporous silica foam (NH2-MOSF) has been developed as a host reactor to realize highly efficient proteolysis in acidic solutions where normal tryptic reactions cannot occur. The digestion protocol consists simply of adding the funct ...

Wiley-VCH GmbH2013

Copper-Catalyzed Tyrosine Nitration

Hubert Girault, Liang Qiao, Yu Lu

Tyrosine nitration, often observed during neurodegenerative disorders under nitrative stress, is usually considered to be induced chemically either by nitric oxide and oxygen forming nitrogen dioxide or by the decomposition of peroxynitrite. It can also be ...

2011

On-Chip Spyhole Nanoelectrospray Ionization Mass Spectrometry for Sensitive Biomarker Detection in Small Volumes

Hubert Girault, Liang Qiao, Xiaoqin Zhong

A polyimide microfluidic chip with a microhole emitter (Ø 10–12 μm) created on top of a microchannel by scanning laser ablation has been designed for nanoelectrospray ionization (spyhole-nanoESI) to couple microfluidics with mass spectrometry. The spyhole- ...

2018

Electrostatic Spray Ionization Mass Spectrometry Imaging

Hubert Girault, Horst Arthur Vogel, Andreas Stephan Lesch, Liang Qiao, Horst Pick, Alexandra Bondarenko, Elena Tobolkina, Xiaoqin Zhong

Imaging samples on a surface by mass spectrometry (MS) requires the combination of MS detection with a scanning mode that enables localized desorption and ionization and/or detection of sample analytes with good spatial resolution. We have developed a new ...

Amer Chemical Soc2014

Plate for matrix-assisted laser desorption ionization mass spectrometry, comprises electroconductive substrate covered with sintered nanoparticles, deposited as array of spots, for supporting ionization of sorbed sample molecules

Hubert Girault, Liang Qiao, Christophe Roussel, Niels Erik Lion, Michel Prudent

NOVELTY - A plate comprises an electroconductive substrate (1) at least partially covered with sintered nanoparticles (2), deposited as an array of individual spots, for use as a sorbing phase for a sample, and for supporting ionization of sorbed sample mo ...

2009

Copper(I) and copper(II) binding to β-amyloid 16 (Aβ16) studied by electrospray ionization mass spectrometry

Hubert Girault, Liang Qiao, Michel Prudent, Yu Lu

Copper-b-amyloid 16 (Aβ16) complexes were investigated by electrospray ionization mass spectrometry (ESI-MS). Copper(I) and (II) complexes were formed on-line in a microchip electrospray emitter by using a sacrificial copper electrode as the anode in posit ...

Royal Society of Chemistry2010

Maldi device and methods of preparation and use thereof

Hubert Girault, Liang Qiao, Horst Pick, Milica Jovic, Yingdi Zhu

A target plate for enhanced matrix-assisted laser desorption/ionization mass spectrometry (MALDI MS) analysis of intact biological entities. The target plate comprises an electrically conductive substrate (1) covered at least partially with immobilised pho ...

2018

Electrostatic-spray ionization mass spectrometry sniffing for perfume fingerprinting

Hubert Girault, Liang Qiao, Elena Tobolkina

RATIONALE: The perfume market is growing significantly, and it is easy to find imitative fragrances of probably all types of perfume. Such imitative fragrances are usually of lower quality than the authentic ones, creating a possible threat for perfume com ...

Wiley-Blackwell2013

Electrostatic Spray Ionization Method

Liang Qiao, Yu Lu, Elena Tobolkina, Romain Sartor

In an electrostatic spray ionization method for spraying a liquid layer from an insulating plate 2, the plate is arranged between two electrodes 1, 4. A constant high voltage power supply 3 is provided and an electric circuit is used to charge and discharg ...

2015

Fingerprinting the Tertiary Structure of Electroadsorbed Lysozyme at Soft Interfaces by Electrostatic Spray Ionization Mass Spectrometry

Hubert Girault, Liang Qiao, Micheal Diarmaid Scanlon

Lysozyme can be electrochemically detected after adsorption at an electrified gel-water interface. Ex-situ characterization by electrostatic spray ionization mass spectrometry provides insights into the interfacial detection mechanism by allowing changes t ...

Royal Society of Chemistry2014

Electrostatic-Spray Ionization Mass Spectrometry

Hubert Girault, Liang Qiao, Natalia Gasilova, Yu Lu, Elena Tobolkina, Romain Sartor

An electrostatic-spray ionization (ESTASI) method has been used for mass spectrometry (MS) analysis of samples deposited in or on an insulating substrate. The ionization is induced by a capacitive coupling between an electrode and the sample. In practice, ...

Amer Chemical Soc2012

Electrochemical reactions and ionization processes

Hubert Girault, Liang Qiao, Niels Erik Lion, Michel Prudent, Mélanie Abonnenc, Hongyan Bi

Electrochemical or photo-electrochemical reactions in both electrospray ionization and laser desorption ionization are discussed stressing the role of the electrode reaction in influencing the ionization process. In particular, upon application of a high v ...

2010

Multiple scanning electrochemical microscopy mapping of tyrosinase in micro-contact printed fruit samples on polyvinylidene fluoride membrane

Hubert Girault, Andreas Stephan Lesch, Liang Qiao, Fernando Cortes Salazar, Alexandra Bondarenko, Tzu-En Lin

Herein, we introduce three orthogonal and compatible methods for detecting tyrosinase, a key factor in fruit browning and skin disorders, with high spatial resolution by means of scanning electrochemical microscopy (SECM). All methods are performed subsequ ...

Elsevier2015

In-source photocatalytic reduction of disulfide bonds during laser desorption ionization

Hubert Girault, Liang Qiao, Hongyan Bi

A photosensitive plate based on sintered TiO2 nanoparticles has been developed to carry out in-source photo-induced reductions for cleavage of disulfide bridges using glucose as a hole scavenger during laser desorption ionization. ...

2008

A microchip emitter for solid phase extraction – gradient elution – mass spectrometry

Hubert Girault, Liang Qiao, Natalia Gasilova, Dmitry Momotenko, Mohammad Reza Pourhaghighi

A microchip electrospray emitter with a magnetic bead trap has been designed for solid phase extraction-gradient elution-mass spectrometry (SPE-GEMS). The goal of this method is the detection of analytes at low concentrations and it is here demonstrated us ...

American Chemical Society2013

Controlling the specific enrichment of multi-phosphorylated peptides on oxide materials: aluminium foil as a target plate for laser desorption ionization mass spectrometry

Hubert Girault, Liang Qiao, Manuel Alejandro Méndez Agudelo, Mohamad Hojeij, Hongyan Bi

A specific multi-phosphopeptide enrichment method is presented to complement current phosphopeptide isolation strategies that normally bias mass spectrometry analysis towards the detection of mono-phosphopeptides. An adsorption model is developed that show ...

2010