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Johan Auwerx

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Related publications (283)

De novo NAD(+) synthesis enhances mitochondrial function and improves health

Elena Katsyuba, Kristina Schoonjans, Johan Auwerx, Dongryeol Ryu, Adrienne Joëlle Laurence Mottis, Karim Laurent Gariani, Marika Olga Zietak

Nicotinamide adenine dinucleotide (NAD(+)) is a co-substrate for several enzymes, including the sirtuin family of NAD(+)-dependent protein deacylases. Beneficial effects of increased NAD(+) levels and sirtuin activation on mitochondrial homeostasis, organi ...

NATURE PUBLISHING GROUP2018

alpha-Amino-beta-carboxymuconate-epsilon-semialdehyde Decarboxylase (ACMSD) Inhibitors as Novel Modulators of De Novo Nicotinamide Adenine Dinucleotide (NAD(+)) Biosynthesis

Elena Katsyuba, Johan Auwerx

2018

Enhanced longevity and metabolism by brown adipose tissue with disruption of the regulator of G protein signaling 14

Elena Katsyuba, Johan Auwerx, Jiahuan Zhang

2018

ERR gamma Preserves Brown Fat Innate Thermogenic Activity

Johan Auwerx, Pooja Jha

2018

Genetic cartography of longevity in humans and mice: Current landscape and horizons

Sylvain Roy, Johan Auwerx, Evan Graehl Williams, Maroun Bou Sleiman

2018

Genetic Regulation of Plasma Lipid Species and Their Association with Metabolic Phenotypes

Johan Auwerx, Evan Graehl Williams, Maroun Bou Sleiman, Karim Laurent Gariani, Pooja Jha, Pedro Moral Quiros

2018

GRAM domain proteins specialize functionally distinct ER-PM contact sites in human cells

Johan Auwerx, Hao Li

2018

Increased cardiac fatty acid oxidation in a mousemodel with decreasedmalonyl-CoA sensitivity of CPT1B

Johan Auwerx, Richardus Houtkooper

2018

Increased Hepatic PDGF-AA Signaling Mediates Liver Insulin Resistance in Obesity-Associated Type 2 Diabetes

Johan Auwerx, Pooja Jha

2018

Loss of Sirt3 accelerates arterial thrombosis by increasing formation of neutrophil extracellular traps and plasma tissue factor activity

Johan Auwerx

2018

Microfluidics-enabled phenotyping of a whole population of C. elegans worms over their embryonic and post-embryonic development at single-organism resolution

Martinus Gijs, Johan Auwerx, Matteo Cornaglia, Laurent Mouchiroud, Raphaël Etienne Jean Trouillon, Maria Cristina Letizia, Vincenzo Sorrentino

2018

Reduced oxidative capacity in macrophages results in systemic insulin resistance

Johan Auwerx, Yoo Hoon Kim, Dongryeol Ryu, Seulgi Kang

Nature Research2018

Repairing Mitochondrial Dysfunction in Disease

Johan Auwerx, Keir Joe Menzies, Vincenzo Sorrentino

2018

Reversible and long-term immobilization in a hydrogel-microbead matrix for high-resolution imaging of Caenorhabditis elegans and other small organisms

Thomas Lehnert, Martinus Gijs, Johan Auwerx, Matteo Cornaglia, Laurent Mouchiroud, Li Dong, Govindan Narayanan Krishnamani, Jingwei Zhang

2018

Systems Analyses Reveal Physiological Roles and Genetic Regulators of Liver Lipid Species

Johan Auwerx, Evan Graehl Williams, Léo Aurélio Diserens, Maroun Bou Sleiman, Karim Laurent Gariani, Pooja Jha, Pedro Moral Quiros

2018

The role of mitochondria in stem cell fate and aging

Johan Auwerx, Hongbo Zhang, Keir Joe Menzies

2018

Oxidative stress and mitochondrial dynamics malfunction are linked in Pelizaeus-Merzbacher disease

Johan Auwerx, Laia Morato Fornaguera

Pelizaeus-Merzbacher disease (PMD) is a fatal hypomyelinating disorder characterized by early impairment of motor development, nystagmus, choreoathetotic movements, ataxia and progressive spasticity. PMD is caused by variations in the proteolipid protein g ...

2018

A microfluidic array for high-content screening at whole-organism resolution

Martinus Gijs, Johan Auwerx, Matteo Cornaglia, Laurent Mouchiroud, Daniel Migliozzi

A main step for the development and the validation of medical drugs is the screening on whole organisms, which gives the systemic information that is missing when using cellular models. Among the organisms of choice, Caenorhabditis elegans is a soil worm w ...

SPIE-INT SOC OPTICAL ENGINEERING2018

Quantifying and Localizing the Mitochondrial Proteome Across Five Tissues in A Mouse Population

Ruedi Aebersold, Johan Auwerx, Evan Graehl Williams, Dongryeol Ryu, Pooja Jha, Jiayi Lan, Jun Yong Kim, Moaraj Hasan

We have used SWATH mass spectrometry to quantify 3648 proteins across 76 proteomes collected from genetically diverse BXD mouse strains in two fractions (mitochondria and total cell) from five tissues: liver, quadriceps, heart, brain, and brown adipose (BA ...

AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC2018

Methods of treating amyloid-beta peptide diseases

Johan Auwerx, Laurent Mouchiroud, Vincenzo Sorrentino

The present invention is directed to a method of treating an amyloid-3 peptide disease in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of a compound that enhances mitochondrial proteostasi ...

2018

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