Florence Pojer

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Related publications (48)

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EspD Is Critical for the Virulence-Mediating ESX-1 Secretion System in Mycobacterium tuberculosis

Stewart Cole, Florence Pojer, Neeraj Dhar, Stefanie Boy-Röttger

ESAT-6 system 1 (ESX-1)-mediated secretion in Mycobacterium tuberculosis is dependent on proteins encoded by the cotranscribed espA-espC-espD gene cluster. While the roles of EspA and EspC with respect to the ESX-1 secretion system have been actively inves ...

American Society for Microbiology2011

Mycobacterium tuberculosis EspB binds phospholipids and mediates EsxA-independent virulence

Stewart Cole, Neeraj Dhar, Florence Pojer, Ming Zhang, Jan Lars Rybniker, Stefanie Boy-Röttger

The type-VII ESX-1 secretion apparatus, encoded by the esx-1 genetic locus, is essential for the export of EsxA and EsxB, two major virulence factors of Mycobacterium tuberculosis. ESX-1 also requires the products of the unlinked espACD operon for optimal ...

Wiley-Blackwell2013

Towards a new combination therapy for tuberculosis with next generation benzothiazinones

Paul Joseph Dyson, Stewart Cole, Florence Pojer, Anthony Vocat, Ruben Hartkoorn, Ming Zhang, Joao Pedro De Almeida Neres, Benoit Lechartier

The benzothiazinone lead compound, BTZ043, kills Mycobacterium tuberculosis by inhibiting the essential flavo-enzyme DprE1, decaprenylphosphoryl-beta-D-ribose 2-epimerase. Here, we synthesized a new series of piperazine-containing benzothiazinones (PBTZ) a ...

2014

Pyridomycin bridges the NADH- and substratebinding pockets of the enoyl reductase InhA

Stewart Cole, Florence Pojer, Ruben Hartkoorn, Joao Pedro De Almeida Neres

Pyridomycin, a natural product with potent antituberculosis activity, inhibits a major drug target, the InhA enoyl reductase. Here, we unveil the co-crystal structure and unique ability of pyridomycin to block both the NADH cofactor- and lipid substrate-bi ...

Nature Publishing Group2014

Lansoprazole is an antituberculous prodrug targeting cytochrome bc1

Stewart Cole, Claudia Sala, Florence Pojer, Andrej Benjak, Anthony Vocat, Philippe Busso, Jan Lars Rybniker

Better antibiotics capable of killing multi-drug-resistant Mycobacterium tuberculosis are urgently needed. Despite extensive drug discovery efforts, only a few promising candidates are on the horizon and alternative screening protocols are required. Here, ...

Nature Publishing Group2015

Palmitoylated acyl protein thioesterase APT2 deforms membranes to extract substrate acyl chains

Matteo Dal Peraro, Françoise Gisou van der Goot Grunberg, Florence Pojer, Laurence Gouzi Abrami, Maria Josefina Marcaida Lopez, Francisco De Magalhães Sarmento Ribeiro De Mesquita, Martina Audagnotto, Patrick Alain Sandoz, Sylvia Ho, Giulia Fonti, Muhammad Umair Anwar

Acyl protein thioesterase APT2 interacts with membranes via its charged beta-tongue, becomes palmitoylated by ZDHHC3/7 and deforms the bilayer to extract substrate acyl chains. APT2 deacylation leads to its membrane release and degradation. ...

NATURE RESEARCH2021

Artificial Metalloenzymes with Two Catalytic Cofactors for Tandem Abiotic Transformations

Xile Hu, Florence Pojer, Kelvin Ka Ching Lau, Weijin Wang

Artificial metalloenzymes (ArMs) enable the integration of abiotic cofactors within a native protein scaffold, allowing for non-natural catalytic activities. Previous ArMs, however, have primarily relied on single cofactor systems, limiting them to only on ...

Wiley-VCH Verlag GmbH2025

A highly potent antibody effective against SARS-CoV-2 variants of concern

Didier Trono, Priscilla Turelli, Florence Pojer, Davide Demurtas, Kelvin Ka Ching Lau, Charlène Mireille Raymonde Raclot, Jérémy Campos

Control of the ongoing SARS-CoV-2 pandemic is endangered by the emergence of viral variants with increased transmission efficiency, resistance to marketed therapeutic antibodies, and reduced sensitivity to vaccine-induced immunity. Here, we screen B cells ...

2021