Publications by Tomislav Milekovic

Related publications (13)

Inhaling xenon ameliorates l -dopa-induced dyskinesia in experimental parkinsonism

Grégoire Courtine, Eduardo Martin Moraud, Tomislav Milekovic, Shiqi Sun

Parkinson's disease motor symptoms are treated with levodopa, but long‐term treatment leads to disabling dyskinesia. Altered synaptic transmission and maladaptive plasticity of corticostriatal glutamatergic projections play a critical role in the pathophys ...

2018

Tau seeds from patients induce progressive supranuclear palsy pathology and symptoms in primates

Grégoire Courtine, Tomislav Milekovic, Flavio Raschella

Progressive supranuclear palsy is a primary tauopathy affecting both neurons and glia and is responsible for both motor and cognitive symptoms. Recently, it has been suggested that progressive supranuclear palsy tauopathy may spread in the brain from cell ...

OXFORD UNIV PRESS2022

Local field potentials in primate motor cortex encode grasp kinetic parameters

Tomislav Milekovic

Reach and grasp kinematics are known to be encoded in the spiking activity of neuronal ensembles and in local field potentials (LFPs) recorded from primate motor cortex during movement planning and execution. However, little is known, especially in LFPs, a ...

Elsevier2015

Configuration of electrical spinal cord stimulation through real-time processing of gait kinematics

Grégoire Courtine, Jocelyne Bloch, Marco Capogrosso, Pavel Musienko, Eduardo Martin Moraud, Nikolaus Wenger, Fabien Bertrand Paul Wagner, Tomislav Milekovic, Jérôme Gandar, Natalia Pavlova

Epidural electrical stimulation (EES) of the spinal cord and real-time processing of gait kinematics are powerful methods for the study of locomotion and the improvement of motor control after injury or in neurological disorders. Here, we describe equipmen ...

Nature Publishing Group2018

Biomaterials. Electronic dura mater for long-term multimodal neural interfaces

Silvestro Micera, Stéphanie Lacour, Grégoire Courtine, Marco Capogrosso, Nicolas Vachicouras, Quentin Barraud, Eduardo Martin Moraud, Ivan Rusev Minev, Léonie Asboth, Tomislav Milekovic, Nikolaus Wenger, Arthur Edouard Hirsch, Pavel Musienko, Jérôme Gandar, Natalia Pavlova

The mechanical mismatch between soft neural tissues and stiff neural implants hinders the long-term performance of implantable neuroprostheses. Here, we designed and fabricated soft neural implants with the shape and elasticity of dura mater, the protectiv ...

American Association for the Advancement of Science2015

Regional specialization of movement encoding across the primate sensorimotor cortex

Rafael Emmanuel Ornelas Kobayashi, Christopher Marc Hitz, Grégoire Courtine, Jocelyne Bloch, Tomislav Milekovic, Simon Borgognon, Ismael Seanez Gonzalez, Nicolò Macellari

The process by which the cerebral cortex generates movements to achieve different tasks remains poorly understood. Here, we leveraged the rich repertoire of well-controlled primate locomotor behaviors to study how task-specific movements are encoded across ...

Springer Science and Business Media LLC2025

Epidural electrical stimulation of the cervical dorsal roots restores voluntary upper limb control in paralyzed monkeys

Stéphanie Lacour, Grégoire Courtine, Jocelyne Bloch, Giuseppe Schiavone, Florian Dylan Fallegger, Quentin Barraud, Tomislav Milekovic, Katia Galan, Nicholas David James

Regaining arm control is a top priority for people with paralysis. Unfortunately, the complexity of the neural mechanisms underlying arm control has limited the effectiveness of neurotechnology approaches. Here, we exploited the neural function of survivin ...

NATURE PORTFOLIO2022

A brain-spine interface alleviating gait deficits after spinal cord injury in primates

Silvestro Micera, Grégoire Courtine, Jocelyne Bloch, Marco Capogrosso, Quentin Barraud, Eduardo Martin Moraud, Fabien Bertrand Paul Wagner, Jérôme Gandar, Jean-Baptiste Mignardot, Tomislav Milekovic, David Allenson Borton, Elodie Rey

Spinal cord injury disrupts the communication between the brain and the spinal circuits that orchestrate movement. To bypass the lesion, brain-computer interfaces(1-3) have directly linked cortical activity to electrical stimulation of muscles, and have th ...

Nature Publishing Group2016

A system for planning and/or providing neurostimulation for a patient

Grégoire Courtine, Marco Capogrosso, Fabien Bertrand Paul Wagner, Vincent Delattre, Tomislav Milekovic, Flavio Raschella

The present invention relates to a system (10) for planning and/or providing neurostimulation for a patient, comprising: - a pathological spinal cord map storage module (48) for storing at least one pathological spinal cord map (49) describing the activati ...

2019

Neuromodulation/neurostimulation system for mitigating locomotor deficits of parkinson's disease, spinal cord injury (sci), stroke and/or other neurological disorders

Grégoire Courtine, Jocelyne Bloch, Jordan Squair, Eduardo Martin Moraud, Léonie Asboth, Robin Jonathan Demesmaeker, Tomislav Milekovic, Newton Cho

The present invention relates to a combined neuromodulation and/or neurostimulation system (10) for mitigating locomotor deficits of/or neuronal disorders, especially Parkinson's disease, said system (10) comprising: - at least one Deep Brain Stimulation ( ...

2023

Two-phase calibration of a neuroprosthetic system

Grégoire Courtine, Marco Capogrosso, Eduardo Martin Moraud, Fabien Bertrand Paul Wagner, Tomislav Milekovic, Jérôme Gandar

Methods and systems are provided for triggering electrical stimulation of a spinal cord during execution of a motor event. In one example, a method comprises monitoring motor cortex activity while execution of a desired motor movement is attempted during a ...

2018

A spinal cord neuroprosthesis for locomotor deficits due to Parkinson's disease

Jean François Pierre Laurens, Auke Ijspeert, Silvestro Micera, Stéphanie Lacour, Grégoire Courtine, Marco Capogrosso, Jocelyne Bloch, Giuseppe Schiavone, Elvira Pirondini, Jordan Squair, Eduardo Martin Moraud, Léonie Asboth, Robin Jonathan Demesmaeker, Tomislav Milekovic, Jimmy James Ravier, Jean-Baptiste Mignardot, Flavio Raschella, Simon Borgognon, Alice Julie Bruel, Carmina Andrea Galvez Solano, Camille Georgette Marie Le Goff-Mignardot, Charlotte Marie Jacques Moerman, David Allenson Borton, Grégory Didier Dumont, Sergio Daniel Hernandez, Nicolò Macellari, Shiqi Sun

People with late-stage Parkinson's disease (PD) often suffer from debilitating locomotor deficits that are resistant to currently available therapies. To alleviate these deficits, we developed a neuroprosthesis operating in closed loop that targets the dor ...

Nature Portfolio2023

Brain-computer interfaces based on intracortical recordings of neural activity for restoration of movement and communication of people with paralysis

Tomislav Milekovic

IEEE2018