Jonas Milani

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Related publications (29)

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Transportable hyperpolarized metabolites

Geoffrey Bodenhausen, David Lyndon Emsley, Sami Jannin, Aurélien Bornet, Jonas Milani, Basile Vuichoud, Aaron James Rossini, Xiao Ji

Nuclear spin hyperpolarization of C-13-labelled metabolites by dissolution dynamic nuclear polarization can enhance the NMR signals of metabolites by several orders of magnitude, which has enabled in vivo metabolic imaging by MRI. However, because of the s ...

Nature Publishing Group2017

An automated system for fast transfer and injection of hyperpolarized solutions

Aurélien Bornet, Jonas Milani

Dissolution dynamic nuclear polarization (dDNP) has become a hyperpolarization method of choice for enhancing nuclear magnetic resonance (NMR) signals. Nuclear spins are polarized in solid frozen samples (in a so-called polarizer) that are subsequently dis ...

Elsevier2021

Microwave frequency modulation to enhance Dissolution Dynamic Nuclear Polarization Dedicated to To Martial Rey, as a token of appreciation

Geoffrey Bodenhausen, Sami Jannin, Aurélien Bornet, Jonas Milani, Basile Vuichoud, Angel Joaquin Perez Linde

Hyperpolarization by Dissolution Dynamic Nuclear Polarization is usually achieved by monochromatic microwave irradiation of the ESR spectrum of free radicals embedded in glasses at 1.2 K and 3.35 T. Hovav et al. (2014) have recently shown that by using fre ...

Elsevier2014

A magnetic tunnel to shelter hyperpolarized fluids

Geoffrey Bodenhausen, Sami Jannin, Aurélien Bornet, Jonas Milani, Pascal Miéville, Basile Vuichoud

To shield solutions carrying hyperpolarized nuclear magnetization from rapid relaxation during transfer through low fields, the transfer duct can be threaded through an array of permanent magnets. The advantages are illustrated for solutions containing hyp ...

American Institute of Physics2015

Highly Repeatable Dissolution Dynamic Nuclear Polarization for Heteronuclear NMR Metabolomics

Geoffrey Bodenhausen, Sami Jannin, Aurélien Bornet, Jonas Milani, Basile Vuichoud, Xiao Ji

At natural C-13 abundance, metabolomics based on heteronuclear NMR is limited by sensitivity. We have recently demonstrated how hyperpolarization by dissolution dynamic nuclear polarization (D-DNP) assisted by cross-polarization (CP) provides a reliable wa ...

Amer Chemical Soc2016

Dissolution dynamic nuclear polarization of deuterated molecules enhanced by cross-polarization

Geoffrey Bodenhausen, Sami Jannin, Jonas Milani, Estel Canet Martinez

We present novel means to hyperpolarize deuterium nuclei in (CD2)-C-13 groups at cryogenic temperatures. The method is based on cross-polarization from H-1 to C-13 and does not require any radio-frequency fields applied to the deuterium nuclei. After rapid ...

Amer Inst Physics2016

Dnp biosensor

Jean-Philippe Ansermet, Jonas Milani, Mika Antero Tamski, Felipe Andres Saenz Padilla

Method for detecting a change in molecular tumbling of an electron-spin labelled system (1) in solution. Nuclear spins of the entire solution are measured in solution using Overhauser dynamic nuclear polarization in a first reference measurement, and then ...

2022

Hyperpolarized NMR of plant and cancer cell extracts at natural abundance

Geoffrey Bodenhausen, Sami Jannin, Aurélien Bornet, Jonas Milani, Basile Vuichoud

Natural abundance C-13 NMR spectra of biological extracts are recorded in a single scan provided that the samples are hyperpolarized by dissolution dynamic nuclear polarization combined with cross polarization. Heteronuclear 2D correlation spectra of hyper ...

Royal Society of Chemistry2015

Toward Quantitative Measurements of Enzyme Kinetics by Dissolution Dynamic Nuclear Polarization

Geoffrey Bodenhausen, Sami Jannin, Aurélien Bornet, Jonas Milani

Dissolution dynamic nuclear polarization (D-DNP) experiments enabled us to study the kinetics of the enzymatic phosphorylation reaction of glucose to form glucose-6-phosphate (G6P) by hexokinase (HK), with or without the presence of an excess of G6P, which ...

2014