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Christian Vergara

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Related publications (21)

Page 1 of 2

The role of computational methods in cardiovascular medicine: a narrative review

Alfio Quarteroni, Luca Dede', Christian Vergara, Stefano Pagani

Background and Objective: Computational models of the cardiovascular system allow for a detailed and quantitative investigation of both physiological and pathological conditions, thanks to their ability to combine clinical-possibly patient-specific-data wi ...

Ame Publishing Company2024

Improved hybrid/GPU algorithm for solving cardiac electrophysiology problems on Purkinje networks

Alfio Quarteroni, Christian Vergara, Toni Mikael Lassila

Cardiac Purkinje fibers provide an important pathway to the coordinated contraction of the heart. We present a numerical algorithm for the solution of electrophysiology problems across the Purkinje network that is efficient enough to be used in in silico s ...

Wiley2017

The cardiovascular system: Mathematical modelling, numerical algorithms and clinical applications

Alfio Quarteroni, Andrea Manzoni, Christian Vergara

Mathematical and numerical modelling of the cardiovascular system is a research topic that has attracted remarkable interest from the mathematical community because of its intrinsic mathematical difficulty and the increasing impact of cardiovascular diseas ...

Cambridge Univ Press2017

An effective algorithm for the generation of patient-specific Purkinje networks in computational electrocardiology

Fabio Nobile, Christian Vergara, Elena Faggiano

The Purkinje network is responsible for the fast and coordinated distribution of the electrical impulse in the ventricle that triggers its contraction. Therefore, it is necessary to model its presence to obtain an accurate patient-specific model of the ven ...

Elsevier2015

Patient-specific generation of the Purkinje network driven by clinical measurements of a normal propagation

Alfio Quarteroni, Fabio Nobile, Christian Vergara, Elena Faggiano

The propagation of the electrical signal in the Purkinje network is the starting point for the activation of the ventricular muscular cells leading to the contraction of the ventricle. In the computational models, describing the electrical activity of the ...

Springer Verlag2014

Geometric multiscale modeling of the cardiovascular system, between theory and practice

Alfio Quarteroni, Christian Vergara

This review paper addresses the so called geometric multiscale approach for the numerical simulation of blood flow problems, from its origin (that we can collocate in the second half of '90s) to our days. By this approach the blood fluid-dynamics in the wh ...

Elsevier2016

Computational study of the risk of restenosis in coronary bypasses

Alfio Quarteroni, Christian Vergara

Coronary artery disease, caused by the buildup of atherosclerotic plaques in the coronary vessel wall, is one of the leading causes of death in the world. For high-risk patients, coronary artery bypass graft is the preferred treatment. Despite overall exce ...

Springer Heidelberg2017

Shear stress alterations in the celiac trunk of patients with a continuous-flow left ventricular assist device as shown by in-silico and in-vitro flow analyses

Alfio Quarteroni, Christian Vergara

BACKGROUND: The use of left ventricular assist devices (LVADs) to treat advanced cardiac heart failure is constantly increasing, although this device leads to high risk for gastrointestinal bleeding. METHODS: Using in-silico flow analysis, we quantified he ...

Elsevier Science Inc2017

Computational comparison of aortic root stresses in presence of stentless and stented aortic valve bio-prostheses

Alfio Quarteroni, Christian Vergara, Elena Faggiano

We provide a computational comparison of the performance of stentless and stented aortic prostheses, in terms of aortic root displacements and internal stresses. To this aim, we consider three real patients; for each of them, we draw the two prostheses con ...

Taylor & Francis Ltd2017

Computational Analysis of Turbulent Hemodynamics in Radiocephalic Arteriovenous Fistulas to Determine the Best Anastomotic Angles

Alfio Quarteroni, Christian Vergara

Background: Hemodynamics has been known to play a major role in the development of intimal hyperplasia leading to arteriovenous fistula failure. The goal of our study is to investigate the influence of different angles of side-to-end radiocephalic anastomo ...

ELSEVIER SCIENCE INC2020

A comprehensive mathematical model for cardiac perfusion

Alfio Quarteroni, Francesco Regazzoni, Christian Vergara

The aim of this paper is to introduce a new mathematical model that simulates myocardial blood perfusion that accounts for multiscale and multiphysics features. Our model incorporates cardiac electrophysiology, active and passive mechanics, hemodynamics, v ...

Nature Portfolio2023

Inexact accurate partitioned algorithms for fluid-structure interaction problems with finite elasticity in haemodynamics

Fabio Nobile, Christian Vergara

In this paper we consider the numerical solution of the three-dimensional fluid–structure interaction problem in haemodynamics, in the case of real geometries, physiological data and finite elasticity vessel deformations. We study some new inexact schemes, ...

Elsevier2014

An image-based computational hemodynamics study of the Systolic Anterior Motion of the mitral valve

Alfio Quarteroni, Luca Dede', Christian Vergara

Systolic Anterior Motion (SAM) of the mitral valve - often associated with Hypertrophic Obstructive Cardiomyopathy (HOCM) - is a cardiac pathology in which a functional subaortic stenosis is induced during systole by the mitral leaflets partially obstructi ...

PERGAMON-ELSEVIER SCIENCE LTD2020

Time accurate partitioned algorithms for the solution of fluid-structure interaction problems in haemodynamics

Fabio Nobile, Christian Vergara

In this work we deal with the numerical solution of the fluid-structure interaction problem arising in the haemodynamic environment. In particular, we consider BDF and Newmark time discretization schemes, and we study different methods for the treatment of ...

2013

A coupled 3D-1D numerical monodomain solver for cardiac electrical activation in the myocardium with detailed Purkinje network

Alfio Quarteroni, Christian Vergara, Toni Mikael Lassila

We present a model for the electrophysiology in the heart to handle the electrical propagation through the Purkinje system and in the myocardium, with two-way coupling at the Purkinje-muscle junctions. In both the subproblems the monodomain model is consid ...

Elsevier2016

Partitioned Algorithms for Fluid-Structure Interaction Problems in Haemodynamics

Fabio Nobile, Christian Vergara

We consider the fluid-structure interaction problem arising in haemodynamic applications. The finite elasticity equations for the vessel are written in Lagrangian form, while the Navier-Stokes equations for the blood in Arbitrary Lagrangian Eulerian form. ...

Birkhäuser-Verlag, Springer2012

Efficient Numerical Schemes for Computing Cardiac Electrical Activation over Realistic Purkinje Networks: Method and Verification

Alfio Quarteroni, Christian Vergara, Toni Mikael Lassila

We present a numerical solver for the fast conduction system in the heart using both a CPU and a hybrid CPU/GPU implementation. To verify both implementations, we construct analytical solutions and show that the L-2-error is similar in both implementations ...

Springer-Verlag2015

A computational fluid-structure interaction analysis of coronary Y-grafts

Alfio Quarteroni, Christian Vergara

Coronary artery disease is one of the leading causes of death worldwide. The stenotic coronary vessels are generally treated with coronary artery bypass grafts (CABGs), which can be either arterial (internal mammary artery, radial artery) or venous (saphen ...

Elsevier Sci Ltd2017

Large eddy simulations for blood dynamics in realistic stenotic carotids

Alfio Quarteroni, Christian Vergara

In this paper, we consider large eddy simulations (LES) for human stenotic carotids in presence of atheromasic plaque, a pathological condition where transitional effects to turbulence may occur, with relevant clinical implications such as plaque rupture. ...

Wiley2017

Helical flows and asymmetry of blood jet in dilated ascending aorta with normally functioning bicuspid valve

Alfio Quarteroni, Christian Vergara, Elena Faggiano

Bicuspid aortic valve (BAV) is associated with aortic dilatation and aneurysm. Several studies evidenced an eccentric systolic flow in ascending aorta associated with increased wall shear stresses (WSS) and the occurrence of an helical systolic flow. This ...

Springer Heidelberg2013