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Lukas Kühn

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Related publications (5)

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Conditional deletion of ferritin H in mice induces loss of iron storage and liver damage

Friedrich Beermann, Lukas Kühn

Ferritin plays a central role in iron metabolism by acting both as iron storage and detoxifying protein. We have generated a ferritin H allele with loxP sites and studied the conditional ferritin H deletion in adult mice. Ten days after Mx-Cre induced dele ...

2009

Informed Graph Learning By Domain Knowledge Injection and Smooth Graph Signal Representation

Olga Fink, Lukas Kühn, Gaëtan Michel Frusque, Keivan Faghih Niresi

Graph signal processing represents an important advancement in the field of data analysis, extending conventional signal processing methodologies to complex networks and thereby facilitating the exploration of informative patterns and structures across var ...

IEEE2024

Short-lived AUF1 p42-binding mRNAs of RANKL and BCL6 have two distinct instability elements each

Barbara Grisoni-Neupert, Philipp Bucher, Giovanna Ambrosini, Lukas Kühn, Ramona Pauchard-Batschulat

Regulation of mRNA stability by RNA-protein interactions contributes significantly to quantitative aspects of gene expression. We have identified potential mRNA targets of the AU-rich element binding protein AUF1. Myc-tagged AUF1 p42 was induced in mouse N ...

2018

Intestinal ferritin H is required for an accurate control of iron absorption

Lukas Kühn

To maintain appropriate body iron levels, iron absorption by the proximal duodenum is thought to be controlled by hepcidin, a polypeptide secreted by hepatocytes in response to high serum iron. Hepcidin limits basolateral iron efflux from the duodenal epit ...

Cell Press2010

Differential translational regulation of IRE-containing mRNAs in Drosophila melanogaster by endogenous IRP and a constitutive human IRP1 mutant

Lukas Kühn

Insects, like vertebrates, express iron regulatory proteins (IRPs) that may regulate proteins in cellular iron storage and energy metabolism. Two mRNAs, an unspliced form of ferritin H mRNA and succinate dehydrogenase subunit b (SDHb) mRNA, are known to co ...

2008