Publications by Priscilla Turelli

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The present invention provides methods for detecting cancer as well as agents and compositions for treating cancer by modulating the expression and/or activity of one or more i) KRAB-containing zinc finger protein (KZFP), ii) mRNA encoding a KZFP, and/or i ...

Genomic imprinting is an epigenetic process regulated by germline-derived DNA methylation, causing parental origin-specific monoallelic gene expression. Zinc finger protein 57 (ZFP57) is critical for maintenance of this epigenetic memory during post-fertil ...

In the first days of embryogenesis, transposable element-embedded regulatory sequences (TEeRS) are silenced by Kruppel-associated box (KRAB) zinc finger proteins (KZFPs). Many TEeRS are subsequently co-opted in transcription networks, but how KZFPs influen ...

Endogenous retroelements (EREs) account for about half of the mouse or human genome, and their potential as insertional mutagens and transcriptional perturbators is suppressed by early embryonic epigenetic silencing. Here, we asked how ERE control is maint ...

ZNF93 is a primate-restricted Krüppel-associated box zinc finger protein responsible for repressing 20- to 12-My-old L1 transposable elements. Here, we reveal that ZNF93 also regulates the key cancer driver APOBEC3B—a mutagenic enzyme linked to tumorigenes ...

Krüppel‐associated box (KRAB)‐containing zinc finger proteins (KZFPs) are encoded in the hundreds by the genomes of higher vertebrates, and many act with the heterochromatin‐inducing KAP1 as repressors of transposable elements (TEs) during early embryogene ...

TRIM5alpha is a restriction factor that limits infection of human cells by so-called N- but not B- or NB-tropic strains of murine leukemia virus (MLV). Here, we performed a mutation-based functional analysis of TRIM5alpha-mediated MLV restriction. Our resu ...

The disclosure provides antibodies, or antigen-binding fragments thereof, and use thereof in prophylaxis, treatment and/or attenuation of a SARS-CoV-2 virus infection. ...

The invention provides anti-SARS-CoV-2 antibodies and use thereof in prophylaxis, treatment and/or attenuation of a SARS-CoV-2 virus infection. ...

Control of the ongoing SARS-CoV-2 pandemic is endangered by the emergence of viral variants with increased transmission efficiency, resistance to marketed therapeutic antibodies, and reduced sensitivity to vaccine-induced immunity. Here, we screen B cells ...

Priscilla Turelli

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Krab-containing zinc finger protein and cancer

ZNF445 is a primary regulator of genomic imprinting

Primate-restricted KRAB zinc finger proteins and target retrotransposons control gene expression in human neurons

Loss of transcriptional control over endogenous retroelements during reprogramming to pluripotency

Cancer cells subvert the primate-specific KRAB zinc finger protein ZNF93 to control APOBEC3B

The interactome of KRAB zinc finger proteins reveals the evolutionary history of their functional diversification

Interfering residues narrow the spectrum of MLV restriction by human TRIM5alpha

Machine Learning in Protein Science De Novo Design of Site-Specific Protein Binders Using Surface Fingerprints

KRAB-ZFPs and transposable elements rewire early human embryonic development transcriptional networks

Anti-sars-cov-2 antibodies and use thereof in the treatment of sars-cov-2 infection

Anti-sars-cov-2 antibodies and use thereof in the treatment of sars-cov-2 infection

Anti-sars-cov-2 antibodies and use thereof in the treatment of sars-cov-2 infection

A highly potent antibody effective against SARS-CoV-2 variants of concern