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Aleksandra Radenovic

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Related publications (153)

Single step synthesis of Schottky-like hybrid graphene - titania interfaces for efficient photocatalysis

The development of 2D nanomaterial coatings across metal surfaces is a challenge due to the mismatch between the metal microstructure and the nanoscale materials. The naturally occurring thin oxidative layer present across all metal surfaces, may lead to l ...

Nature Research2018

Investigating Focal Adhesion Substructures by Localization Microscopy

Daniel Sage, Aleksandra Radenovic, Lely Feletti, Hendrik Georges Deschout

Cells rely on focal adhesions (FAs) to carry out a variety of important tasks, including motion, environmental sensing, and adhesion to the extracellular matrix. Although attaining a fundamental characterization of FAs is a compelling goal, their extensive ...

Elsevier2017

Geometrical Effect in 2D Nanopores

Andras Kis, Aleksandra Radenovic, Duncan Thomas Lindsay Alexander, Davide Deiana, Ke Liu, Dumitru Dumcenco, Martina Lihter, Vasiliki Tileli, Aditya Sarathy

A long-standing problem in the application of solid-state nanopores is the lack of the precise control over the geometry of artificially formed pores compared to the well-defined geometry in their biological counterpart, that is, protein nanopores. To date ...

American Chemical Society (ACS)2017

Combining PALM and SOFI for quantitative imaging of focal adhesions in living cells

Theo Lasser, Aleksandra Radenovic, Lely Feletti, Azat Sharipov, Hendrik Georges Deschout, Tomas Lukes

Focal adhesions are complicated assemblies of hundreds of proteins that allow cells to sense their extracellular matrix and adhere to it. Although most focal adhesion proteins have been identified, their spatial organization in living cells remains challen ...

Spie-Int Soc Optical Engineering2017

Molecular sensing device

Aleksandra Radenovic, Jiandong Feng, Ke Liu

Molecular sensing system including: a sensing device (5) comprising at least one support layer (10), and an active layer (6) mounted on said support layer and having at least one nano-pore (12) configured for translocation of a molecular analyte (18) there ...

2017

Complementarity of PALM and SOFI for super-resolution live-cell imaging of focal adhesions

Marcel Leutenegger, Theo Lasser, Aleksandra Radenovic, Lely Feletti, Daniel Pawel Szlag, Azat Sharipov, Hendrik Georges Deschout, Tomas Lukes

Live-cell imaging of focal adhesions requires a sufficiently high temporal resolution, which remains a challenge for super-resolution microscopy. Here we address this important issue by combining photoactivated localization microscopy (PALM) with super-res ...

Nature Publishing Group2016

Manufacturing of orifices in glass like materials, e.g. Nanocapillaries, and objects obtained according to this process

Aleksandra Radenovic, Lorenz Jan Steinbock

The ability to reshape nanopores and observe their shrinkage under an electron microscope is a powerful and novel technique14,17. It increases the sensitivity of the resistive pulse sensing and enables to detect very short and small molecules12,31. However ...

2016

Single Molecule Localization and Discrimination of DNA–Protein Complexes by Controlled Translocation Through Nanocapillaries

Aleksandra Radenovic, Sebastian Maerkl, Sebastian James Davis, Roman Bulushev, Ekaterina Emilova Petrova, Sanjin Marion

Through the use of optical tweezers we performed controlled translocations of DNA-protein complexes through nanocapillaries. We used RNA polymerase (RNAP) with two binding sites on a 7.2 kbp DNA fragment and a dCas9 protein tailored to have five binding si ...

American Chemical Society (ACS)2016

On characterizing protein spatial clusters with correlation approaches

Aleksandra Radenovic, Jayakrishnan Unnikrishnan, Arun Shivanandan

Spatial aggregation of proteins might have functional importance, e.g., in signaling, and nano-imaging can be used to study them. Such studies require accurate characterization of clusters based on noisy data. A set of spatial correlation approaches free o ...

Nature Research2016

Single-layer MoS2 nanopores as nanopower generators

Andras Kis, Aleksandra Radenovic, Michael Graf, Dmitry Ovchinnikov, Jiandong Feng, Ke Liu, Dumitru Dumcenco

Making use of the osmotic pressure difference between fresh water and seawater is an attractive, renewable and clean way to generate power and is known as 'blue energy'(1-3). Another electrokinetic phenomenon, called the streaming potential, occurs when an ...

Nature Publishing Group2016

Nanopore forming method and uses thereof

Aleksandra Radenovic, Jiandong Feng, Ke Liu

Method for making nanopores in thin layers or monolayers of transition metal dichalcogenides comprising the steps of provinding a suspended transistion metal dichalcogenide layer (1) in an electrolyte (2), applying a transmembrane voltage (V) high enough t ...

2016

Investigating Cellular Focal Adhesions on Nano-Patterned Substrates with Dual Color Photo-Activated Localization Microscopy

Aleksandra Radenovic, Hendrik Georges Deschout

Cell Press2015

Relevance of the Drag Force during Controlled Translocation of a DNA–Protein Complex through a Glass Nanocapillary

Aleksandra Radenovic, Roman Bulushev, Sanjin Marion

Combination of glass nanocapillaries with optical tweezers allowed us to detect DNA-protein complexes in physiological conditions. In this system, a protein bound to DNA is characterized by a simultaneous change of the force and ionic current signals from ...

American Chemical Society (ACS)2015

Accounting for Limited Detection Efficiency and Localization Precision in Cluster Analysis in Single Molecule Localization Microscopy

Aleksandra Radenovic, Jayakrishnan Unnikrishnan, Arun Shivanandan

Single Molecule Localization Microscopy techniques like PhotoActivated Localization Microscopy, with their sub-diffraction limit spatial resolution, have been popularly used to characterize the spatial organization of membrane proteins, by means of quantit ...

Public Library of Science2015

High-Resolution Correlative Microscopy: Bridging the Gap between Single Molecule Localization Microscopy and Atomic Force Microscopy

Aleksandra Radenovic, Lely Feletti, Georg Fantner, Pascal Damian Odermatt, Arun Shivanandan, Hendrik Georges Deschout, Adrian Pascal Nievergelt, Radek Jankele

Nanoscale characterization of living samples has become essential for modern biology. Atomic force microscopy (AFM) creates topological images of fragile biological structures from biomolecules to living cells in aqueous environments. However, correlating ...

American Chemical Society (ACS)2015

Single florescent nanodiamond in a three dimensional ABEL trap

Aleksandra Radenovic, Metin Kayci

Three dimensional single particle trapping and manipulation is an outstanding challenge in various fields ranging from basic physics to life sciences. By monitoring the response of a trapped particle to a designed environment one can extract its characteri ...

Nature Publishing Group2015

Electrochemical Reaction in Single Layer MoS2: nanopores opened atom by atom

Andras Kis, Aleksandra Radenovic, Michael Graf, Duncan Thomas Lindsay Alexander, Daria Krasnozhon, Roman Bulushev, Jiandong Feng, Ke Liu, Dumitru Dumcenco, Martina Lihter

Ultrathin nanopore membranes based on 2D materials have demonstrated ultimate resolution toward DNA sequencing. Among them, molybdenum disulfide (MoS2) shows long-term stability as well as superior sensitivity enabling high throughput performance. The trad ...

American Chemical Society (ACS)2015

Molybdenum Disulfide Nanopores: Why 3 Atoms are Better than One?

Aleksandra Radenovic

Cell Press2015

Large-Area Epitaxial Monolayer MoS2

Andras Kis, Aleksandra Radenovic, Anna Fontcuberta i Morral, Philippe Gillet, Nicola Marzari, Simone Bertolazzi, Oriol López Sánchez, Daria Krasnozhon, Ming-Wei Chen, Dmitry Ovchinnikov, Marco Gibertini, Dumitru Dumcenco, Yen-Cheng Kung, Kolyo Marinov

Two-dimensional semiconductors such as MoS2 are an emerging material family with wide-ranging potential applications in electronics, optoelectronics, and energy harvesting. Large-area growth methods are needed to open the way to applications. Control over ...

Amer Chemical Soc2015

Revealing GPCR oligomerization at the single-molecule level through a nanoscopic lens: methods, dynamics and biological function

Aleksandra Radenovic, Paolo Annibale, Marco Scarselli

The introduction of super-resolution fluorescence microscopy has allowed the visualization of single proteins in their biological environment. Recently, these techniques have been applied to determine the organization of class A G-protein-coupled receptors ...

Wiley-Blackwell2015

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