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Graham Knott

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Related publications (97)

Page 5 of 5

Parkin functionally interacts with PGC-1 proportional to to preserve mitochondria and protect dopaminergic neurons

Johan Auwerx, Patrick Aebischer, Bernard Schneider, Graham Knott, Norman Lionel Moullan, Davide D'Amico, Nathalie Marie Géraldine Bernard, Lu Zheng

To understand the cause of Parkinson's disease (PD), it is important to determine the functional interactions between factors linked to the disease. Parkin is associated with autosomal recessive early-onset PD, and controls the transcription of PGC-1a, a m ...

Oxford University Press2017

Learning Structured Models for Segmentation of 2D and 3D Imagery

Pascal Fua, Graham Knott, Carlos Joaquin Becker, Kevin Smith, Aurélien Lucchi, Pablo Marquez Neila, Yunpeng Li

Efficient and accurate segmentation of cellular structures in microscopic data is an essential task in medical imaging. Many state-of-the-art approaches to image segmentation use structured models whose parameters must be carefully chosen for optimal perfo ...

Institute of Electrical and Electronics Engineers2015

The RNA-Binding Protein PUM2 Impairs Mitochondrial Dynamics and Mitophagy During Aging

Johan Auwerx, Bernard Schneider, Kristina Schoonjans, Graham Knott, Hao Li, Adrienne Joëlle Laurence Mottis, Vincenzo Sorrentino, Davide D'Amico, Mario Romani, Vera Monica Lemos Da Silva

Little information is available about how post-transcriptional mechanisms regulate the aging process. Here, we show that the RNA-binding protein Pumilio2 (PUM2), which is a translation repressor, is induced upon aging and acts as a negative regulator of li ...

CELL PRESS2019

Homeostatic control of dopamine by astrocytes in the postnatal maturation of the prefrontal cortex

Graham Knott, Corrado Cali

Wiley2017

Probabilistic Atlases to Enforce Topological Constraints

Pascal Fua, Graham Knott, Pamuditha Udaranga Wickramasinghe

Probabilistic atlases (PAs) have long been used in standard segmentation approaches and, more recently, in conjunction with Convolutional Neural Networks (CNNs). However, their use has been restricted to relatively standardized structures such as the brain ...

2019

Advances in automated 3D cortex image data acquisition

Graham Knott

2008

NanoSIMS analysis of an isotopically labelled organometallic ruthenium(II) drug to probe its distribution and state in vitro

Paul Joseph Dyson, Anders Meibom, Kai Johnsson, Graham Knott, Stéphane Laurent Escrig, Mary-Claude Croisier-Coeytaux

Royal Society of Chemistry2015

Serial section scanning electron microscopy of adult brain tissue using focused ion beam milling

Graham Knott

2008

Cold shock protects the brain

Graham Knott

Nature Publishing Group2015

A Single Cell Approach for Safe Gene Therapy

Graham Knott, Yann Barrandon, Ariane Rochat

Mary Ann Liebert2009

Ultrastructurally smooth thick partitioning and volume stitching for large-scale connectomics

Graham Knott

Focused-ion-beam scanning electron microscopy (FIB-SEM) has become an essential tool for studying neural tissue at resolutions below 10 nm x 10 nm x 10 nm, producing data sets optimized for automatic connectome tracing. We present a technical advance, ultr ...

Nature Publishing Group2015

3D ultrastructural study of tissues by serial block-face scanning electron microscopy

Graham Knott

Wiley-Blackwell2012

Dendritic spine plasticity-Current understanding from in vivo studies

Graham Knott

2008

Early invasion of the bladder wall by solitary bacteria protects UPEC from antibiotics and neutrophil swarms in an organoid model

Graham Knott, John McKinney, Neeraj Dhar, Vivek Vijay Thacker, Kunal Sharma, Anaëlle Fabienne Dubois, François Signorino-Gelo

2021

Graham Knott

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Parkin functionally interacts with PGC-1 proportional to to preserve mitochondria and protect dopaminergic neurons

Learning Structured Models for Segmentation of 2D and 3D Imagery

The RNA-Binding Protein PUM2 Impairs Mitochondrial Dynamics and Mitophagy During Aging

Homeostatic control of dopamine by astrocytes in the postnatal maturation of the prefrontal cortex

Probabilistic Atlases to Enforce Topological Constraints

Advances in automated 3D cortex image data acquisition

NanoSIMS analysis of an isotopically labelled organometallic ruthenium(II) drug to probe its distribution and state in vitro

Serial section scanning electron microscopy of adult brain tissue using focused ion beam milling

Cold shock protects the brain

A Single Cell Approach for Safe Gene Therapy

Ultrastructurally smooth thick partitioning and volume stitching for large-scale connectomics

3D ultrastructural study of tissues by serial block-face scanning electron microscopy

Dendritic spine plasticity-Current understanding from in vivo studies

Early invasion of the bladder wall by solitary bacteria protects UPEC from antibiotics and neutrophil swarms in an organoid model

High-Throughput 3D Cellular Imaging

C6-O-03Quantifying adult brain ultrastructure using focussed ion beam scanning electron microscopy

PSD-95 promotes synaptogenesis and multiinnervated spine formation through nitric oxide signaling