Publications by Luca Dede' | EPFL Graph Search

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Mechano-electric feedbacks (MEFs), which model how mechanical stimuli are transduced into electrical signals, have received sparse investigation by considering electromechanical simulations in simplified scenarios. In this paper, we study the effects of di ...

We analyse the haemodynamics of the left atrium, highlighting differences between healthy individuals and patients affected by atrial fibrillation. The computational study is based on patient-specific geometries of the left atria to simulate blood flow dyn ...

Cardiac in silico numerical simulations are based on mathematical models describing the physical processes involved in the heart function. In this review paper, we critically survey biophysically-detailed mathematical models describing the subcellular mech ...

This paper considers numerical simulations of fluid-structure interaction (FSI) problems in hemodynamics for idealized geometries of healthy cerebral arteries modeled by both nonlinear isotropic and anisotropic material constitutive laws. In particular, it ...

We propose a reduced ODE model for the mechanical activation of cardiac myofilaments, which is based on explicit spatial representation of nearest-neighbour interactions. Our model is derived from the cooperative Markov Chain model of Washio et al. (Cell M ...

We consider Isogeometric Analysis (IGA) for the numerical solution of the electrophysiology of the atria, which in this work is modeled by means of the bidomain equations on thin surfaces. First, we consider the bidomain equations coupled with the Roger-Mc ...

We consider the numerical simulation of integrated heart models for the study of the cardiac functioning with particular emphasis on the coupling of the muscle contraction, the fluid dynamics of the left ventricle, and the interaction with the valves. We a ...

We consider Isogeometric Analysis in the framework of the Galerkin method for the spatial approximation of cardiac electrophysiology models defined on NURBS surfaces; specifically, we perform a numerical comparison between basis functions of degree p >= 1 ...

In this paper, we propose a monolithic algorithm for the numerical solution of the electromechanics model of the left ventricle in the human heart. Our coupled model integrates the monodomain equation with the Bueno-Orovio minimal model for electrophysiolo ...

We consider the numerical approximation of high order Partial Differential Equations (PDEs) defined on surfaces in the three dimensional space, with particular emphasis on closed surfaces. We consider computational domains that can be represented by B-spli ...

We consider the numerical approximation of lipid biomembranes at equilibrium described by the Canham-Helfrich model, according to which the bending energy is minimized under area and volume constraints. Energy minimization is performed via L-2-gradient flo ...

This paper presents an analysis of hyperelastic constitutive models for continuous bodies both from a modeling and numerical point of view. Contributions are made within the context of finite element numerical simulations. Numerical results with relevance ...

Parametrized systems of Differential Algebraic Equations (DAEs) stand at the base of several mathematical models in Microelectronics, Computational Fluid Dynamics and other Engineering fields. Since the dimension of these systems can be huge, high computat ...

In this paper, we propose the mathematical and finite element analysis of a second-order partial differential equation endowed with a generalized Robin boundary condition which involves the Laplace--Beltrami operator by introducing a function space $H^1(\O ...

We consider the numerical approximation of geometric Partial Differential Equations (PDEs) defined on surfaces in the 3D space. In particular, we focus on the geometric PDEs deriving from the minimization of an energy functional by L2L2-gradient flow. We a ...

Predicting the electrical behavior of the heart, from the cellular scale to the tissue level, relies on the numerical approximation of coupled nonlinear dynamical systems. These systems describe the cardiac action potential, that is the polarization/depola ...

We propose a novel approach for smoothing on surfaces. More precisely, we aim at estimating functions lying on a surface, starting from noisy and discrete measurements. The surface is represented by NURBS, which are geometrical representations commonly use ...

In the context of SARS-CoV-2 pandemic, mathematical modelling has played a funda-mental role for making forecasts, simulating scenarios and evaluating the impact of pre-ventive political, social and pharmaceutical measures. Optimal control theory represent ...

Finite deformations of planar slender beams for which shear strain can be neglected are described by the extensible-elastica model, where the strain-displacement relation is geometrically exact and the Biot stress–strain relation is linear. However, if the ...

We investigate a finite element approximation of an initial boundary value problem associated with parabolic Partial Differential Equations endowed with mixed time varying boundary conditions, switching from essential to natural and vice versa. The switchi ...

Luca Dede'

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The role of mechano-electric feedbacks and hemodynamic coupling in scar-related ventricular tachycardia

Impact of atrial fibrillation on left atrium haemodynamics: A computational fluid dynamics study

Active Force Generation in Cardiac Muscle Cells: Mathematical Modeling and Numerical Simulation of the Actin-Myosin Interaction

Fluid-structure interaction simulations of cerebral arteries modeled by isotropic and anisotropic constitutive laws

Active contraction of cardiac cells: a reduced model for sarcomere dynamics with cooperative interactions

Isogeometric Analysis of the electrophysiology in the human heart: Numerical simulation of the bidomain equations on the atria

Coupled models for integrated heart simulations: a numerical study of the fluid dynamics in the left ventricle

Isogeometric approximation of cardiac electrophysiology models on surfaces: An accuracy study with application to the human left atrium

A monolithic algorithm for the simulation of cardiac electromechanics in the human left ventricle

Isogeometric Analysis of high order Partial Differential Equations on surfaces

Biomembrane modeling with isogeometric analysis

A numerical study of isotropic and anisotropic constitutive models with relevance to healthy and unhealthy cerebral arterial tissues

Reduced Basis Method for Parametrized Differential Algebraic Equations

Well-Posedness, Regularity, and Convergence Analysis of the Finite Element Approximation of a Generalized Robin Boundary Value Problem

Isogeometric Analysis of geometric partial differential equations

Deep learning-based reduced order models in cardiac electrophysiology

IGS: an IsoGeometric approach for Smoothing on surfaces

Optimized numerical solutions of SIRDVW multiage model controlling SARS-CoV-2 vaccine roll out: An application to the Italian scenario

Isogeometric rotation-free analysis of planar extensible-elastica for static and dynamic applications

Nitsche's method for parabolic Partial Differential Equations with mixed time varying boundary conditions